DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nec and Serping1

DIOPT Version :9

Sequence 1:	NP_524851.1	Gene:	nec / 45908	FlyBaseID:	FBgn0002930	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_033906.2	Gene:	Serping1 / 12258	MGIID:	894696	Length:	504	Species:	Mus musculus

Alignment Length:	461	Identity:	114/461 - (24%)
Similarity:	204/461 - (44%)	Gaps:	87/461 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 QHQRNPRPELGLRSLPGNPWTQNNQEAISDVVAVDLTKREPVTPPPNRPPPV--FSYMDRFSSEL 114
            ||.: |..:|...| ||.|...::.:..:   |.||..:  .|..|..|.|:  .|..||.|||.
Mouse    88 QHSQ-PAAQLPTDS-PGQPPLNSSSQPST---ASDLPTQ--ATTEPFCPEPLAQCSDSDRDSSEA 145

  Fly   115 -FKEII-------------KSQSQQNVVFSPFSVHALLA-LIYGASDGKTFRELQKAGEFSKNAM 164
             ..|.:             ...::.|:.|||||:.:||. ::.||.| .|...|:       :.:
Mouse   146 KLSEALTDFSVKLYHAFSATKMAKTNMAFSPFSIASLLTQVLLGAGD-STKSNLE-------SIL 202

  Fly   165 AVAQDFESVIKYKKHLEGADLTLATKVYYNRELGGVNHSYDEYAKFYFSAGTEAVDMQNAKDTAA 229
            :..:||..|.:..|......:|..::::::.:| .:..:|...::..:.:....:    ..|:||
Mouse   203 SYPKDFACVHQALKGFSSKGVTSVSQIFHSPDL-AIRDTYVNASQSLYGSSPRVL----GPDSAA 262

  Fly   230 K---INAWVMDTTRNKIRDLV--TPTDVDPQTQALLVNAVYFQGRWEHEFATMD-TSPYDFQHTN 288
            .   ||.||.:.|.:|||.|:  .|:|    |..:|:||||...:|:..|.... .:|:.::::
Mouse   263 NLELINTWVAENTNHKIRKLLDSLPSD----TCLVLLNAVYLSAKWKITFEPKKMMAPFFYKNS- 322

  Fly   289 GRISKVAMMFNDDVYGLAELPELGATA----LELAYKDSATSMLILLPNETTGLGKMLQQLSRPE 349
              :.||.|| :...|.:|:..:....|    |:|::..|...::.:.|.         .||...|
Mouse   323 --MIKVPMM-SSVKYPVAQFDDHTLKAKVGQLQLSHNLSFVIVVPVFPK---------HQLKDVE 375

  Fly   350 FDLNRVAHR--LRRQSVA------VRLPKFQFEFEQDMTEPLKNLGVHQMFTPNSQVTKLMDQP- 405
            ..||....:  :::..::      :.:|..:.:..|||...::.|.... ||.:..:..|.:.|
Mouse   376 KALNPTVFKAIMKKLELSKFLPTYLTMPHIKVKSSQDMLSVMEKLEFFD-FTYDLNLCGLTEDPD 439

  Fly   406 VRVSKILQKAYINVGEAGTEASAASYAKFVPLSLPPKPTEFVANRPFVFAV-----RTPASVLFI 465
            ::||.:..:..:.:.|:|.||:|||...| ..|||    .|...|||:|.:     |.|   :|:
Mouse   440 LQVSAMKHETVLELTESGVEAAAASAISF-GRSLP----IFEVQRPFLFLLWDQQHRFP---VFM 496

  Fly   466 GHVEYP 471
            |.|..|
Mouse   497 GRVYDP 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nec	NP_524851.1	SERPIN	108..468	CDD:238101	96/398 (24%)
Serping1	NP_033906.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..67
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..141		17/59 (29%)
		serpinG1_C1-INH	141..500	CDD:381006	94/397 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100