Protein Alignment mr and Anapc2

DIOPT Version :10

• Sequence 1: NP_611862.1
• Gene: mr / 45906
• FlyBaseID: FBgn0002791
• Length: 802
• Species: Drosophila melanogaster
• Sequence 2: NP_780509.2
• Gene: Anapc2 / 99152
• MGIID: 2139135
• Length: 837
• Species: Mus musculus
• Alignment Length: 773
• Identity: 295/773 - (38%)
• Similarity: 460/773 - (59%)
• Gaps: 60/773 - (7%)

  Fly    58 IQSTIRNVLVPKFWKHIHDGLVSSKLQGWINDQALAIEALPDKNGLFTQFIDAINELHDSFQSLM 122
            :|:.::..:..:||..|  .|..:.:     |:...:..|.|..||....:|..  ||.  ..|:
Mouse    94 LQNDLQGNIATEFWNAI--ALRENSV-----DEPQCLGLLLDAFGLLESRLDPY--LHS--LELL 147

  Fly   123 QVKPRLIQLVGAETKPTAKTVKLMQEEGIKNCLRDCLLAQLPPNFSVVVGAFYWVHFKLFTKASN 187
            :...||..|:||..:...:.|..|        ||..|....|..|..:|...|....:::.::..
Mouse   148 EKWTRLGLLMGAGAQGLREKVHTM--------LRGVLFFSTPRTFQEMVQRLYGRFLRVYMQSKR 204

  Fly   188 LALTTVDSDVFDEL----------------LCVGCNFEAEQCCCQRLTDMVNKTNMKLFEMNLID 236
            ......|.::..||                ||.||..:.:||.|::..:..|:.:..|..::|::
Mouse   205 KGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCGSDKQQCWCRQALEQFNQLSQVLHRLSLLE 269

  Fly   237 RLTGSALTALIKLKIKEHISDTCMGIFDRSHLKQLETWLSDVIMSWLTNIFTEWKSKDSISDIEV 301
            |:...|:|..:....:|.:.|.|.|.::||.|::...|:..|: .||..:|.:    |:.:....
Mouse   270 RVCAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVV-GWLGKVFLQ----DNPTRPTS 329

  Fly   302 PE---SVKSFKVKLTYFMYETFAQSVIGQFFSIIIDYPDSIPAIDDLKICMEKIDMRVYLTESLR 363
            ||   :::.::..:..|.|..:|...|.:.||||.|:|||.|||:|||.|:|:.|.|..|..||:
Mouse   330 PEAGNTLRRWRCHVQRFFYRIYATLRIEELFSIIRDFPDSRPAIEDLKYCLERTDQRQQLLVSLK 394

  Fly   364 NSLEARILHPGVNTMDILTGYVAAIKAIRHLDSTGVILEMVTAPIKDYLRKRNDTVRRVVTGLT- 427
            .:||.|:|||||||.||:|.|::||||:|.||.:.||||:...||:.|||.|.||||::|.|||
Mouse   395 VALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVACEPIRRYLRTREDTVRQIVAGLTG 459

  Fly   428 -EEGPTDLSEELAKGETIKECKDSG---TDEFSNWENWQPDPFGIDASIMQYNSSRKMRSADIIS 488
             .:|..||:.||:|  |...|.::|   .|:....|:|.|||  :||..::  ||.|.||:||||
Mouse   460 DSDGTGDLAVELSK--TDPACLETGQDSEDDSGEPEDWVPDP--VDADPVK--SSSKRRSSDIIS 518

  Fly   489 MVVDIYGSKELFMTEYRNLMADRLLAQLDFNSEKEIRNLELLKIRFGESLLHSCEVMLKDVTDSK 553
            ::|.|||||:||:.|||:|:|||||.|..|:.|:||||:||||:||||:.:|.|||||||:.||:
Mouse   519 LLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSR 583

  Fly   554 RINAHIHSDGDR---TENQLFDISSLIVSAQFWPSFNKESLQLPEEIENEFKKYTKAYEAYKGNR 615
            ||||:|..:.::   .|...|.:.::|:|::|||.|..|.|::||:|......|.|.||..|..|
Mouse   584 RINANIREEDEKRPVEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALDVYCKKYEKLKAMR 648

  Fly   616 TLNWRTVTGRVNIEIEIGDRTMEMVVSPILAVIIYHFQTKNEWTIEDLSSITKVPASALRRRLSF 680
            ||:|:...|.|.:::|:.|||:.:.|:|:.||::.:||.:..||:|:||.:.|:|.:.||||:|.
Mouse   649 TLSWKHTLGLVTMDVELADRTLSVAVTPVQAVVLLYFQNQASWTLEELSKVVKMPVALLRRRMSV 713

  Fly   681 WQNHGLISETTPGIFTLLEKESEKSQYEDMSLAEADEEDLESAMASASDQREEELQVFWSYIVGM 745
            |...|::.|..||.|:::|:|..:.: ::|.|.::|:|. :|.|||.:||:||||.:||:||..|
Mouse   714 WLQQGVLREEPPGTFSVIEEERPQDR-DNMVLIDSDDES-DSGMASQADQKEEELLLFWAYIQAM 776

  Fly   746 LTNLDSMPIDRIHQMLKLFASHSGGV-EFTQDELKHFLQRKVREHKLIFSGGVYQLAK 802
            ||||:|:.::||:.||::|......: |....||:.:||:|||:.:||:|.|||:|.|
Mouse   777 LTNLESLSLERIYSMLRMFVMTGPALAEIDLQELQGYLQKKVRDQQLIYSAGVYRLPK 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mr	NP_611862.1	CULLIN	494..632	CDD:214545	69/140 (49%)
		ANAPC2	741..800	CDD:462556	27/59 (46%)
Anapc2	NP_780509.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	478..508		10/33 (30%)
		Cullin	<527..709	CDD:459983	84/181 (46%)
		APC2	772..832	CDD:198081	27/59 (46%)