DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mr and APC2

DIOPT Version :9

Sequence 1:	NP_611862.1	Gene:	mr / 45906	FlyBaseID:	FBgn0002791	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_013228.1	Gene:	APC2 / 850818	SGDID:	S000004117	Length:	853	Species:	Saccharomyces cerevisiae

Alignment Length:	850	Identity:	185/850 - (21%)
Similarity:	334/850 - (39%)	Gaps:	182/850 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 TQFIDAINEL------HDSFQSLMQVKP------RLIQLV---GAETKP-----TAKTVKLMQEE 149
            |..:|.:|.|      :|: :|..|::|      .:|:::   .|.|.|     |::....:..|
Yeast    28 TNIVDDLNSLLTWMSPNDA-KSNHQLRPPSLRIKNIIKVLFPNNATTSPYSMINTSQANNSIVNE 91

  Fly   150 GIKNC-LRDCLLAQLPPNFSVVVGAFYWVHFKLFTKASNLA------------LTTVDSDVFDEL 201
            |..|. |:..|.:.|...:...|...:::||.......::.            :...|.:|.|..
Yeast    92 GNTNKELQLQLFSTLKEFYIFQVRYHFFLHFNNINYLKDIQRWENYYEFPLRYVPIFDVNVNDWA 156

  Fly   202 L--------CVGCNFEAEQCCCQRLTDMVNKTNMKLFEMNLIDRL---TGS-ALTALIKLKIKEH 254
            |        .:..|.:.:.....||..::...:..|.: |||..|   .|| :.|.||...:...
Yeast   157 LELNSLRHYLLNRNIKFKNNLRTRLDKLIMDDDFDLAD-NLIQWLKSANGSLSSTELIVNALYSK 220

  Fly   255 ISDTCMGIFDRSHLKQLETWLSDVIMSWLTNIFTEWKSKDSISDIEVPESVKSFKVKLTYFMYET 319
            |:..|.....|...|:.      :||........::.|:.| ..:..||.    ..:||..::..
Yeast   221 INKFCEDNMSRVWNKRF------MIMETFNKFINQYWSQFS-KLVGCPED----DHELTTTVFNC 274

  Fly   320 FAQSVI----GQFFSI-IIDYPDSIPAIDDLKICMEKIDMRVYLTESLRNSLEARILHPGVNTMD 379
            |..:.:    .:.|.| ::.||||...:.:|:..|:.......:..:..:..:..||:|.|.|:|
Yeast   275 FESNFLRIRTNEIFDICVLAYPDSKVTLLELRKIMKDFKDYTNIVTTFLSDFKKYILNPSVTTVD 339

  Fly   380 ILTGYVAAIKAIRHLDSTGVILEMVTAPIKDYLRKRNDTVRRVVTGLTEEGPTDLSEEL------ 438
            .|..||..|||...||.||..|..:|..:|.|.::|...|..::..:.:....:|.|::
Yeast   340 ALLRYVKTIKAFLVLDPTGRCLHSITTFVKPYFQERKHLVNVLLYAMLDLPEEELKEKINFNVDM 404

  Fly   439 -AKGETIKECKDSGTDEFSN-------------WE-----------------------------N 460
             |....:....||..::.:|             |.                             .
Yeast   405 KALLSLVDTLHDSDINQDTNITKRDKNKKSPFLWNLKVKGKRELNKDLPIRHAMLYEHILNYYIA 469

  Fly   461 WQPDPFGIDASIMQYNSSRKMRSADIISMVVDIYGSKELFMTEYRNLMADRLLAQLDFNS--EKE 523
            |.|:|    ..::..|........::..:::|::.|:|.|::|:|||:.|||.. |.|.:  ||.
Yeast   470 WVPEP----NDMIPGNIKSSYIKTNLFEVLLDLFESREFFISEFRNLLTDRLFT-LKFYTLDEKW 529

  Fly   524 IRNLELLK---IRFGE--------------------------SLLHSCEVMLKDVTDSKRINAHI 559
            .|.|:|::   ::|.|                          |.|:|.:|||.|:..|:.:...:
Yeast   530 TRCLKLIREKIVKFTETSHSNYITNGILGLLETTAPAADADQSNLNSIDVMLWDIKCSEELCRKM 594

  Fly   560 HSDGDRTENQLFDISSL-------IVSAQFW------PSFNKESLQLPEEIENEFKKYTKAYEAY 611
            |           :::.|       .:|..:|      ...|..:..||.::|.|.:||:..|...
Yeast   595 H-----------EVAGLDPIIFPKFISLLYWKYNCDTQGSNDLAFHLPIDLERELQKYSDIYSQL 648

  Fly   612 KGNRTLNWRTVTGRVNIEIEIGD-RTMEMVVSPILAVIIYHFQTKNE----WTIEDLSSITKVPA 671
            |..|.|......|:|.|::...| |.:.:.||.....:|..|.:.|:    .::|.||....:..
Yeast   649 KPGRKLQLCKDKGKVEIQLAFKDGRKLVLDVSLEQCSVINQFDSPNDEPICLSLEQLSESLNIAP 713

  Fly   672 SALRRRLSFWQNHGLISETTPGIFTLLE-KESEKSQYEDMSLAEADEEDLESAMASASDQREE-E 734
            ..|...|.||...|::.:.. |.::::| .|.:..|.:..:..|.:..:.|....|..:::.| .
Yeast   714 PRLTHLLDFWIQKGVLLKEN-GTYSVIEHSEMDFDQAQKTAPMEIENSNYELHNDSEIERKYELT 777

  Fly   735 LQVFWSYIVGMLTNLDSMPIDRIHQMLKLFASHSGGV-EFTQDELKHFLQRKVREHKLIF-SGGV 797
            ||....:|.||||||.:|.:.:||..||:......|. ..|..:|:.:|.....|.:|.: :.|.
Yeast   778 LQRSLPFIEGMLTNLGAMKLHKIHSFLKITVPKDWGYNRITLQQLEGYLNTLADEGRLKYIANGS 842

  Fly   798 YQLAK 802
            |::.|
Yeast   843 YEIVK 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mr	NP_611862.1	CULLIN	494..632	CDD:214545	45/181 (25%)
mr	NP_611862.1	APC2	741..800	CDD:198081	20/60 (33%)
APC2	NP_013228.1	Cullin	<628..732	CDD:395716	28/103 (27%)
APC2	NP_013228.1	APC2	784..845	CDD:198081	20/60 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344176
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2165
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	115	1.000	Inparanoid score	I1341
Isobase	1	0.950	-	0	Normalized mean entropy	S3734
OMA	1	1.010	-	-		QHG56055
OrthoFinder	1	1.000	-	-		FOG0005254
OrthoInspector	1	1.000	-	-		oto99692
orthoMCL	1	0.900	-	-		OOG6_103028
Panther	1	1.100	-	-	LDO	PTHR45957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R69
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.780