DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mr and APC2

DIOPT Version :9

Sequence 1:	NP_611862.1	Gene:	mr / 45906	FlyBaseID:	FBgn0002791	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_178543.2	Gene:	APC2 / 815008	AraportID:	AT2G04660	Length:	865	Species:	Arabidopsis thaliana

Alignment Length:	877	Identity:	267/877 - (30%)
Similarity:	422/877 - (48%)	Gaps:	126/877 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VSNDPVEENVFQNVRQHLMVLGSIDTFAAVVDLEIQSTIRNVLVPKFWKHIHDGLVSSKLQGWIN 88
            :|:|.::|           :..|.|.|...|:..|..|..:::..:|..|:: .|....|...:.
plant    17 LSDDAIQE-----------ITESYDGFFTTVESLIAGTGDSLVEDEFVSHVY-CLCKYGLDSLVR 69

  Fly    89 DQAL-AIEALPDKNGL--FTQFIDAINEL--HDSFQSLMQVKPRLIQLVGAETKPTAKTVKLM-- 146
            |..| ::|...:|.|.  |.|..||.:|.  |:..:.:..|..:.::.:..|.:...|.:.::
plant    70 DHFLRSLEQAFEKGGASSFWQHFDAYSEKKHHNYGEEIQIVLCKALEEISIEKQYHEKCLSIVVH 134

  Fly   147 -----QEEG-----------------IKNCLRDCLLAQLPPNFSVVVGAFYWVHFKLFTKASNLA 189
                 :|:.                 .::.|...|:..||.:|..::   :| :||  .:...|:
plant   135 ALQSFKEQSSDDRQNSDTERVHLFSRFQSMLSSTLMTTLPQHFPEIL---HW-YFK--ERLEELS 193

  Fly   190 LTTVDSDVFDE-----------LLCVGCNFEAEQCCCQ-------RLTDMVNKTNMKLFEM---N 233
             ..:|.|..:|           |.......:.::.|.|       :|...:.|....|..:   :
plant   194 -AIMDGDGIEEQEDDCMDLDEKLRYKNGEMDVDEGCSQGKRLGHDKLVKNIGKVVRDLRSIGFTS 257

  Fly   234 LIDRLTGSALTALIKLKIKEHISDTCMGIFDRSHLKQLETWLSDVIMSWLTNIFTEWKS------ 292
            :.:....||:..|:|.|:.:...|.    :..|.|:.::.|:..|.:.:|..:.:....
plant   258 MAENAYASAIFLLLKAKVHDLAGDD----YRTSVLESIKEWIQTVPLQFLNALLSYLGDSVSYGT 318

  Fly   293 -------------KDSISDIEVP-ESVKSFKVKLTYFMYETFAQSVIGQFFSIIIDYPDSIPAID 343
                         ..|.|.:..| |.:..:|::|.||.|||.....|.:.|.||:|||:|.|||:
plant   319 TSSGLTSPLACCPSPSFSRVVTPSEGIVRWKLRLEYFAYETLQDLRIAKLFEIIVDYPESSPAIE 383

  Fly   344 DLKICMEKIDMRVYLTESLRNSLEARILHPGVNTMDILTGYVAAIKAIRHLDSTGVILEMVTAPI 408
            |||.|:|.......|.||..:||:.|:|..|.:|.|||..||:.|||:|.:|..||.||.|..||
plant   384 DLKQCLEYTGQHSKLVESFISSLKYRLLTAGASTNDILHQYVSTIKALRAIDPAGVFLEAVGEPI 448

  Fly   409 KDYLRKRNDTVRRVVTGLTE---------EGPTD-LSEELAKGETIKE----CKDSGTDEFSNWE 459
            :||||.|.||::.:||.||:         ..|.| |.|||.:.|..:|    ..|..||:...|.
plant   449 RDYLRGRKDTIKCIVTMLTDGSGGNANGSGNPGDSLLEELMRDEESQENVGFDDDFHTDDKQAWI 513

  Fly   460 N---WQPDPFGIDASIMQYNSSRKMRSADIISMVVDIYGSKELFMTEYRNLMADRLLAQLDFNSE 521
            |   |:|||...|    ....|...|..||:.|:|||.||||..:.|||.::|::||.:.|::.:
plant   514 NASRWEPDPVEAD----PLKGSLSQRKVDILGMLVDIIGSKEQLVNEYRVMLAEKLLNKTDYDID 574

  Fly   522 KEIRNLELLKIRFGESLLHSCEVMLKDVTDSKRINAHI----HSDGDRTENQLF--DISSLIVSA 580
            .|||.:|||||.|||:.:..||:||.|:.||||:|.:|    .:..:..||:|.  .::|.|:|.
plant   575 TEIRTVELLKIHFGEASMQRCEIMLNDLIDSKRVNTNIKKASQTGAELRENELSVDTLTSTILST 639

  Fly   581 QFWPSFNKESLQLPEEIENEFKKYTKAYEAYKGNRTLNWRTVTGRVNIEIEIGDRTMEMVVSPIL 645
            .|||....|.|:||..::.....|...|...|..|.|.|:...|.|.:|::..||.|:..|||..
plant   640 NFWPPIQDEPLELPGPVDKLLSDYANRYHEIKTPRKLLWKKNLGTVKLELQFEDRAMQFTVSPTH 704

  Fly   646 AVIIYHFQTKNEWTIEDLSSITKVPASALRRRLSFWQNHGLISETT-----PGIFTLLEKESEKS 705
            |.||..||.|..||.:||:.:..:|..||.||::||.:.|::.|:|     ..:.||:|..::..
plant   705 AAIIMQFQEKKSWTYKDLAEVIGIPIDALNRRVNFWISKGVLRESTGANSNSSVLTLVESITDSG 769

  Fly   706 QYEDMSLAEADEEDLESAMASASDQREEELQVFWSYIVGMLTNLDSMPIDRIHQMLKLFASHSGG 770
            :.|...|...:||. |:::||..||..:|:.::..:|:|||||..||.::|||..||:|......
plant   770 KNEGEELLTGEEEG-ETSIASVEDQLRKEMTIYEKFIMGMLTNFGSMALERIHNTLKMFCVADPS 833

  Fly   771 VEFTQDELKHFLQRKVREHKLIFSGGVYQLAK 802
            .:.:..:|:.||...|.|.||.|..|:|.|.|
plant   834 YDKSLQQLQSFLSGLVSEEKLEFRDGMYLLKK 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mr	NP_611862.1	CULLIN	494..632	CDD:214545	55/143 (38%)
mr	NP_611862.1	APC2	741..800	CDD:198081	24/58 (41%)
APC2	NP_178543.2	Cullin	<557..735	CDD:395716	69/177 (39%)
APC2	NP_178543.2	ANAPC2	804..863	CDD:400832	24/58 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	149	1.000	Domainoid score	I1428
eggNOG	1	0.900	-	-		E1_KOG2165
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8359
Inparanoid	1	1.050	357	1.000	Inparanoid score	I601
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D570797at2759
OrthoFinder	1	1.000	-	-		FOG0005254
OrthoInspector	1	1.000	-	-		oto3704
orthoMCL	1	0.900	-	-		OOG6_103028
Panther	1	1.100	-	-	LDO	PTHR45957
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4265
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.830