DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mr and Cul5

DIOPT Version :9

Sequence 1:	NP_611862.1	Gene:	mr / 45906	FlyBaseID:	FBgn0002791	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_651665.2	Gene:	Cul5 / 43434	FlyBaseID:	FBgn0039632	Length:	852	Species:	Drosophila melanogaster

Alignment Length:	827	Identity:	156/827 - (18%)
Similarity:	276/827 - (33%)	Gaps:	282/827 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FDALWADVLRIFPVLGGANAVSNDPVEENVFQNV--RQHLMVLGSIDTFAAVVDLEIQSTIRNVL 66
            |:.:|.|..||...|     :..|.|.:..:|::  ..|.:.|......|.:.|. :|..|...:
  Fly    13 FEEVWPDKRRIVLKL-----LRQDTVSQREWQDLFFGVHFVCLWDEKGAAKIYDC-LQQDIVEFI 71

  Fly    67 VPKFWKHIHDGLVSSKLQGWINDQALAIEALPDKNGLFTQFIDAINELHDSFQSL---MQVKP-- 126
            |.          ..|::|....:|||....:.:....|||    .|.|...|:.|   .||||
  Fly    72 VQ----------AQSQVQAQRGEQALLATYIVEWRKFFTQ----SNYLPLPFRQLEQSPQVKPSS 122

  Fly   127 ------RLIQLVGAETKPTAKTV------------------------------------------ 143
                  ..:...||.|...|...
  Fly   123 SGSSSSASVSASGASTSAAAAAAATSCSGQAGKSGASTSAAAGASTSAAAAAASTSASTSSAAAA 187

  Fly   144 ---------------------------KLMQEEGIKNCLRDCLLAQLPPNFSVVVGAFYWVHFKL 181
                                       |||.:...|:...|                   :..:|
  Fly   188 AAASGSGSSSSSTSTSKKNPTEDSPVRKLMLDSWNKHIFHD-------------------IKHRL 233

  Fly   182 FTKASNLALTTVDSDVFDELLCVGCNFEAEQCCCQRLTDMVNKTNMKL------FEMNLIDRLTG 240
            ...|..:.....:.|.:|..|.||..        :...::.:....||      |||..:
  Fly   234 QESAMKIVHAERNGDAYDAQLVVGVR--------ESYVNLSSNAEDKLEIYRENFEMAYL----- 285

  Fly   241 SALTALIKLKIKEHISDTCMGIFDRSHLKQLETWLSDVIMSWLTNIFTEWKSKDSISDIEVPESV 305
            .|.....:||..|...:.  |:.  :::|..::.|.:          .|.::|..:..
  Fly   286 KATVEFYRLKSAEQQQEN--GVL--AYMKYADSKLRE----------EEVRAKRYLEP------- 329

  Fly   306 KSFKVKLTYFMYETFAQSVIGQFFSIIIDYPDSI----PAIDDLKICMEKIDMRVYLTE--SLRN 364
            .||.: |||.:...           :|:|:.:||    ||:           :|.|.||  :|..
  Fly   330 SSFSI-LTYTLVNV-----------LIVDHLNSIIAECPAL-----------IRDYETERLNLMF 371

  Fly   365 SLEARILH-PGVNTM--DILTGYVAAIKAIRHLDSTGV-----ILEMVTAPIKDYL-------RK 414
            .|..|::| .||..|  |:.          ||:.|.|:     ..|::|...:.|:       .|
  Fly   372 RLMDRVMHGVGVEPMMGDLQ----------RHIMSAGLADMLSASEVITQDSEKYVERLLELFNK 426

  Fly   415 RNDTVR-------RVVTG--------------LTEEGPTDLSEELAKGETIKECKDSGTDEFSNW 458
            .:|.||       |.:|.              ...|.||.::....| .|..|.|  ..:..:|:
  Fly   427 FSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTSIANRGVK-YTAPESK--CPELLANY 488

  Fly   459 ENWQPDPFGIDASIMQYNSSRKMRSADI------ISMVVDIYGSKELFMTEYRNLMADRLLAQLD 517
                     .|..:.:...|:::.|..|      :.:|:....:|::||..::..:..||:....
  Fly   489 ---------CDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTS 544

  Fly   518 FNSEKEIRNLELLK-IRFGESLLHSCEVMLKDVTDSKRINAHIHSDGDRTENQLFDISSLIVSAQ 581
            .:||||...:|.|: :......::....|.:|:..|:.:|....:...|.:    .|:..|::|.
  Fly   545 ADSEKEEDIVEWLREVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHD----AINIKILNAG 605

  Fly   582 FWPSFNKE-SLQLPEEIENEFKKYTKAYEAYKGNRTLNW------RTVT-----GRVNIEIEIGD 634
            .|...::. |:.||.|:|:......:.|:.....|.|.|      .|:|     ||.::::
  Fly   606 AWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFVNNFGRYDLDV---- 666

  Fly   635 RTMEMVVSPILAVIIYHFQTKNEWTIEDLSSITKVPASALRRRLSFW 681
            .|.:|.|     :..::.:..::.:.|:|...|::|...|||.|  |
  Fly   667 TTFQMAV-----LFAWNQRQHDKISYENLRLATELPDPELRRTL--W 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mr	NP_611862.1	CULLIN	494..632	CDD:214545	33/150 (22%)
mr	NP_611862.1	APC2	741..800	CDD:198081
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	149/802 (19%)
		CULLIN	520..655	CDD:214545	30/138 (22%)
		Cullin_Nedd8	779..846	CDD:214883
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930