DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mr and Cul1

DIOPT Version :9

Sequence 1:	NP_611862.1	Gene:	mr / 45906	FlyBaseID:	FBgn0002791	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	846	Identity:	166/846 - (19%)
Similarity:	306/846 - (36%)	Gaps:	192/846 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 QSTIRNVLVPKFWKHIHDGLVS-------------SKLQGWINDQALAIEALPD-----KNG--- 102
            |:|.:.|.:...|..:.:|::.             .:....:.|...::.|.|.     |.|
  Fly     8 QTTQKLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQ 72

  Fly   103 -LFTQFIDAINELHDSFQSLMQVKPRLIQ----LVGAETK-----PTAKTVKLMQEEGIKNCL-- 155
             :..:..|.:.:...|:.|.:..|.:.|.    |:...||     ..:.||.    :||.|.|
  Fly    73 LVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVL----DGICNYLNR 133

  Fly   156 ----RDCLLAQLPPNFSVVVGAFYWVHFKLFTKASNLALTTVDSDVFDELLCVGCNFEAEQCCCQ 216
                |:|...|                 |...|...|||......:|                 |
  Fly   134 NWVKRECEEGQ-----------------KGIYKIYRLALVAWKGHLF-----------------Q 164

  Fly   217 RLTDMVNKTNMKLFEM----NLIDR-LTGSALTALIKLKIKEHISDTCMG-------------IF 263
            .|.:.|.|..:|..|.    .||:| |....:...::|...|..:|....             |.
  Fly   165 VLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIA 229

  Fly   264 DRSHLKQLETWLSDVIMSWLTNIFTEWKSKDSISDIEVPESVKSFKVK--LTYFMYETFAQSVIG 326
            |.|...:.|   ||..:|  ||..||:.........|..:.|:.|..|  |:| ::||.|..:..
  Fly   230 DTSAFYEKE---SDAFLS--TNTVTEYLKHVENRLEEETQRVRGFNSKNGLSY-LHETTADVLKS 288

  Fly   327 QFFSIII---------DYPDSIPA--IDDLKICMEKIDMRVY---------LTESLRNSLEARIL 371
            ....::|         ::.:.:.|  .||||        |:|         ||: |::.||..||
  Fly   289 TCEEVLIEKHLKIFHTEFQNLLNADRNDDLK--------RMYSLVALSSKNLTD-LKSILENHIL 344

  Fly   372 HPGVNTMDILTGYVAAIKAIRHLDSTGVILEMVT--APIKDYLRKRNDTVRRVVTGLTEEGPTDL 434
            |.|.             :||....:|....:..|  ..|.|..:|.|   ..|:|....:.....
  Fly   345 HQGT-------------EAIAKCCTTDAANDPKTYVQTILDVHKKYN---ALVLTAFNNDNGFVA 393

  Fly   435 SEELAKGETIKECKDSGTDEFSNWENWQPDPFGIDASIMQYNSSRKMRSADI------ISMVVDI 493
            :.:.|.|:.|    :|.....:|..:..|:.......::...||:.....::      :.:|...
  Fly   394 ALDKACGKFI----NSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKY 454

  Fly   494 YGSKELFMTEYRNLMADRLLAQLDFNSEKEIRNLELLKIRFGESLLHSCEVMLKDVTDSKRINAH 558
            ...|::|...|..::|.||:.....:.:.|...:..||...|.......:.|.:|:..||.:|::
  Fly   455 IEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSY 519

  Fly   559 IHSD-GDRTENQLFDISSLIVSAQFWPSFNKESLQLPEEIENEFKKYTKAYEAYKGNRTLNW--R 620
            .... .::......|....::|:..||.....:..||.|:|...:::.:.|.|....|.|||  :
  Fly   520 FKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQ 584

  Fly   621 TVTGRVNIEIEIGD-RTMEMVVSPILAVIIYHFQTKNEWTIEDLSSITKVPASALRRRL------ 678
            ...|.:.:.:...: .|..:..|.....::..|..:..:|::.|...|:.....|.:.|
  Fly   585 MCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILLKA 649

  Fly   679 ----SFWQNHGLISETTPGIFTLLEKESEKSQYEDMSLAEADEEDLESAMASASDQREEELQ-VF 738
                |....:.|..|:|..:|  |:.:::|.:   :::.:..:.:|:....:.....||:.: :.
  Fly   650 KVLTSSDNENSLTPESTVELF--LDYKNKKRR---ININQPLKTELKVEQETVHKHIEEDRKLLI 709

  Fly   739 WSYIVGML--------TNLDSMPIDRIHQMLKLFASHSGGVEFTQDEL--KHFLQRKVREHKLIF 793
            .:.||.::        |||.|   :.::|:...|......::...|.|  |.:|:| :..||..:
  Fly   710 QAAIVRIMKMRKRLNHTNLIS---EVLNQLSTRFKPKVPVIKKCIDILIEKEYLER-MEGHKDTY 770

  Fly   794 S 794
            |
  Fly   771 S 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mr	NP_611862.1	CULLIN	494..632	CDD:214545	30/140 (21%)
mr	NP_611862.1	APC2	741..800	CDD:198081	16/64 (25%)
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	140/720 (19%)
		CULLIN	454..593	CDD:214545	30/138 (22%)
		Cullin_Nedd8	701..765	CDD:214883	15/67 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467930
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840