Protein Alignment mr and Cul2

DIOPT Version :9

• Sequence 1: NP_611862.1
• Gene: mr / 45906
• FlyBaseID: FBgn0002791
• Length: 802
• Species: Drosophila melanogaster
• Sequence 2: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Alignment Length: 695
• Identity: 111/695 - (15%)
• Similarity: 240/695 - (34%)
• Gaps: 199/695 - (28%)

  Fly   216 QRLTDM----------------VNKTNMKLFEMNLIDRLTGSALTALIKLKIKEHISDTCMGIFD 264
            |::||.                :.:..:.::.:.:|:.|:...:..:::....:..|:   |..|
  Fly   125 QKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASN---GTLD 186

  Fly   265 RSHLKQLETWLSDVIMSWLTNIFTEWKSKDSISDIEVPESVKSFKVKLTYFMYETFAQSVIGQFF 329
            . |..|:   ::.||.|:                :||.:..|:..:||...::|.......|.::
  Fly   187 H-HRVQI---INGVIHSF----------------VEVQDYKKTGSLKLYQELFEGPMLEASGAYY 231

  Fly   330 SIIIDYPDSIPAIDDLKICMEKIDMRVYLTESLR----NSLEA-RILHPGVNTMDILTGYVAAIK 389
            :            |:....:.:..:..|:.|.:|    .|..| :.||            |:::.
  Fly   232 T------------DEANKLLHRCSVSEYMQEVIRILEYESRRAQKFLH------------VSSLP 272

  Fly   390 AIRH-------LDSTGVIL----EMVT--------------APIKDYLRKRNDTVRRVVTGLTEE 429
            .:|.       .|..|.|.    |||:              .||.|.|  :::.:...:..:..|
  Fly   273 KLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMYVVLKPIPDNL--KSELITTFLDHIKSE 335

  Fly   430 GPTDLSEELAKGETI------------KECKDSGTDEFSNWENWQPDPFGID------ASIMQYN 476
            |...:|  ..|||.|            .:.::...|.|.|      |...:.      ||::...
  Fly   336 GLQTVS--ALKGENIHIAFVENMLKVHHKYQELIADVFEN------DSLFLSALDKACASVINRR 392

  Fly   477 SSRKM--RSADIISMVVD-------------------------IYGSKELFMTEYRNLMADRLLA 514
            .:.:.  |||:.::...|                         ....|:::...|..|:|.||:.
  Fly   393 PTERQPCRSAEYVAKYCDTLLKKSKTCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIH 457

  Fly   515 QLDFNSEKEIRNLELLKIRFGESLLHSCEVMLKDVTDS----KRINAHIHSDGDRTENQLFDISS 575
            :...:.:.|...:..||...|....:....|..|::.|    .:.|.|:.   |...:...:::.
  Fly   458 EQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLK---DSNVDLGINLAI 519

  Fly   576 LIVSAQFWPSFNKESL--QLPEEIENEFKKYTKAYEAYKGNRTLNWRTVTGRVNIEIEIGDRTME 638
            .::.|..||..:.:.:  .:|:|.|...|.:...|......|.|.|........:::....::..
  Fly   520 KVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHLKKSYI 584

  Fly   639 MVVSPILAVIIYHFQTKNEWTIEDLSSITKVPASALRR--------RLSFWQNHGLISETTPGIF 695
            :.:......||..|:|.:..:..::.:..::.....::        :|....:..|..||.  |.
  Fly   585 VTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPIIESKLLNASSENLAGETR--IE 647

  Fly   696 TLLEKESEKSQYE-DMSLAEADEEDLESAMASASDQREEELQVFWSYIVGMLTNLDSMPIDRIHQ 759
            ..|:..::::::: ..:|.:...:::|..:.|..:.|:..||.               .|.||.:
  Fly   648 LNLDYTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQA---------------AIVRIMK 697

  Fly   760 MLKLFASHSGGVEFTQDELKH--FLQRKVREHKLIFSGGVYQLAK 802
            ..|:              |||  .:|..:...|:.|:..:..:.|
  Fly   698 ARKV--------------LKHNALIQEVLSLSKVSFTPNIAMIKK 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mr	NP_611862.1	CULLIN	494..632	CDD:214545	27/143 (19%)
		APC2	741..800	CDD:198081	10/60 (17%)
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	89/573 (16%)
		CULLIN	436..575	CDD:214545	27/141 (19%)
		Cullin_Nedd8	680..745	CDD:214883	14/78 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467932
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930