Protein Alignment mr and Cul3

DIOPT Version :9

• Sequence 1: NP_611862.1
• Gene: mr / 45906
• FlyBaseID: FBgn0002791
• Length: 802
• Species: Drosophila melanogaster
• Sequence 2: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Alignment Length: 621
• Identity: 104/621 - (16%)
• Similarity: 203/621 - (32%)
• Gaps: 184/621 - (29%)

  Fly   218 LTDMVNKTNMKL-FEM------NLIDRLTGSALTALIKLKIKEHI-----SDTCMGIFDRSHLKQ 270
            :.::..|.|..| ||.      |::....|:.|...::..:.||:     :|....:......|.
  Fly   200 IQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKL 264

  Fly   271 LETW---------LSDVIMSWLTNIFTEWKSKDSISD----------IEVPESVKSFKVKLTYFM 316
            .:.|         :.|::| ::..::.:.:..|::.:          :...|..|:.:.||...:
  Fly   265 NQAWTDHQTSMVMIRDILM-YMDRVYVQQREVDNVYNLGLILFRDQVVRYSEIQKALREKLLGMV 328

  Fly   317 Y--------------------------------ETFAQSVIGQFFSIIIDYPDSIPAIDDLKICM 349
            .                                |.|.:..:.|..:.......:..|.::..:.:
  Fly   329 MEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYI 393

  Fly   350 EKIDMRVYLTESLRNSL------EARILHPGVNTMDILTGYVAAIKAIRHLDSTGVI-------- 400
            :|::.|: ..||.|.:|      |.||:.  |...:::..:   ::.|..::::||:
  Fly   394 KKVEARI-TEESSRAALYLDKDTEPRIVR--VVEEELIKKH---MRPIVEMENSGVVYMIKNSKT 452

  Fly   401 -----------------LEMVTAPIKDYLRKRNDTVRRVVTGLTEEGPTD--------------- 433
                             |:::...:..|||::.    |::....|.|.|:
  Fly   453 EDLACTYKLFSRLKEEGLKVIADTMSAYLREQG----RMLVKEEENGNTNPITFVQNLLDLKDRF 513

  Fly   434 ---LSEELAKGETIKECKDSGTDEFSNWENWQPDPFG--IDASIMQYNSSRKMRSADIISMVVD- 492
               |....|.....|....|..:.|.|..|..|:...  ||..:   ....|..|...|..::|
  Fly   514 DQFLVHSFANDRIFKNVISSDFEHFLNLNNKSPEYLSLFIDDKL---KKGGKGMSEQEIESILDK 575

  Fly   493 ------IYGSKELFMTEYRNLMADRLLAQLDFNSEKEIRNLELLKIRFGESLLHSCEVMLKDVTD 551
                  ....|::|...|:..:|.|||.....:.:.|...:..||...|.......|.|.||::.
  Fly   576 TMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSV 640

  Fly   552 SKRI---------NAHIHSDGDRTENQLFDISSLIVSAQFWPSF----NKESLQLPEEIENEFKK 603
            |..|         |.::...|       .:::..|::..|||:.    |......|.|..:.||.
  Fly   641 SNTIMDEFKNFVNNNNLSLGG-------VELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKN 698

  Fly   604 YTKAYEAYKGNRTLNWRTVTGRVNIE-IEIGDRTME-------------------------MVVS 642
            :   |......|.|..:...|...|. :..|.:.:|                         :.||
  Fly   699 F---YLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVS 760

  Fly   643 PILAVIIYHFQTKNEWTIEDLSSITKVPASALRRRL 678
            .....::..|..::..|.:|:...|.:|...|.|.|
  Fly   761 TYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRAL 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mr	NP_611862.1	CULLIN	494..632	CDD:214545	33/151 (22%)
		APC2	741..800	CDD:198081
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	104/621 (17%)
		CULLIN	582..724	CDD:214545	33/151 (22%)
		Cullin_Nedd8	866..926	CDD:287520

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467935
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930