Protein Alignment mr and apc2

DIOPT Version :10

• Sequence 1: NP_611862.1
• Gene: mr / 45906
• FlyBaseID: FBgn0002791
• Length: 802
• Species: Drosophila melanogaster
• Sequence 2: NP_001018806.1
• Gene: apc2 / 3361204
• PomBaseID: SPBP23A10.04
• Length: 681
• Species: Schizosaccharomyces pombe
• Alignment Length: 732
• Identity: 203/732 - (27%)
• Similarity: 345/732 - (47%)
• Gaps: 113/732 - (15%)

  Fly   105 TQFIDAINELHDSFQSLMQVKPRLIQLVGAETKPTAKTVKLMQEEGIKNCLRDCLLAQLPPNFSV 169
            |..:|.|::|...|.:  .::..|:::                  .:||.   |.|..|....|
pombe    26 TPVLDFIDKLRIHFYT--TIRQNLLKI------------------DLKNI---CSLHDLTDQLS- 66

  Fly   170 VVGAFYWVHFKLFTKASNLALTTVDSDVFDELL-CVGCNFEAEQCCCQR----------LTD--- 220
                .:|:.::     .::..:.:.|...|.:| |.       :|.|:|          ||:
pombe    67 ----DFWLVYE-----QSVLESPILSPELDRILTCF-------RCLCRRYLPISVIESVLTEYLD 115

  Fly   221 ------MVNKTN----MKLFEMNLIDRLTGSALTALIKLKIKEHISDTCMGIFDRSHLKQLETWL 275
                  :.:|||    |:.| ..|.::.....|::::|.:....:         :.|:..|.|
pombe   116 QVLKVWLESKTNPCLDMEKF-FQLCEKFKQLGLSSVLKERFVYVL---------QLHVGSLLT-- 168

  Fly   276 SDVIMSWLTNIF---TEWKSKD---------SISDIEVPESVKSFKVKLTYFMYETFAQSVIGQF 328
            :...|||..:::   .||...:         |:|:..|       .|:|.:.:.:..|.......
pombe   169 TRYAMSWEQSVYHEALEWIRTEFGVLVEHVFSLSNPAV-------LVQLDHLVSQILAHLRSDNI 226

  Fly   329 FSIIIDYPDSIPAIDDLKICMEKIDMRVYLTESLRNSLEARILHPGVNTMDILTGYVAAIKAIRH 393
            ..|::.||:|:.||:||::...:...|.||||:......:.||....::..||..||:.|:....
pombe   227 LDIVLHYPNSLGAIEDLRLVARQKQQRQYLTETFVKDCTSSILTASSDSSYILLFYVSTIRCFVA 291

  Fly   394 LDSTGVILEMVTAPIKDYLRKRNDTVRRVVTGLTEEGPTDLSEELAKGETIKECKDSGTDEFSNW 458
            ||..||:|:....||:.:|.:|.|..:.:|:.|..:|...|..||::..|  |..||.||.|.|:
pombe   292 LDPPGVLLDKAAKPIRSFLNEREDAYKCLVSLLFVDGEKGLRSELSQIPT--ENIDSTTDRFDNY 354

  Fly   459 ENWQPDPFGIDASIMQYNSSRKMRSADIISMVVDIYGSKELFMTEYRNLMADRLLAQLDFNSEKE 523
             :|.|||  |||:    ...:|....|::..::.|:.|||..:.|.:.|:|||||...|::.|.|
pombe   355 -HWMPDP--IDAA----PDFKKPTDRDVVGSLISIFKSKEPLVKELQLLLADRLLQLTDYHYEVE 412

  Fly   524 IRNLELLKIRFGESLLHSCEVMLKDVTDSKRINAHIHSDGDRTENQLFDISSLIVSAQFWPSFNK 588
            .:|:|.||.||||::|..|.|||.|:.:|:.|:..||.:...::.    :...|:|..|||:.:.
pombe   413 AKNIEFLKYRFGETVLQMCSVMLNDIENSRFIDQSIHMENYVSKG----LHVTILSRLFWPTLSV 473

  Fly   589 ESLQLPEEIENEFKKYTKAYEAYKGNRTLNWRTVTGRVNIEIEIGDRTMEMVVSPILAVIIYHFQ 653
            ....||..::.|...|.:.|...|..|.|.:....|.|.:|||:.|||:.:.|:|..|..|..|:
pombe   474 RYFHLPGPLKKELDAYAEEYRERKRKRELVFLPNLGSVELEIELEDRTLTLTVTPEQAAFISLFE 538

  Fly   654 TKNEWTIEDLSSITKVPASALRRRLSFWQNHGLISETTPGIFTLLEKESEKSQYEDMSLAEADEE 718
            ..:...||..:.:...|...:.|.|.||.:|.::::.....:.:.|.|:|.:     :....||.
pombe   539 ETSTLHIEKAAELLDQPKEIVERHLKFWLHHRVLTDIGDDRYRVRETEAETA-----TETVLDEI 598

  Fly   719 DLESAMASASDQREEELQVFWSYIVGMLTNLDSMPIDRIHQMLKLFASHSGGVEFTQDELKHFLQ 783
            ...||:.|.::....|::|:||::|||||||.::.::|||.||.:|.....|...||.||:.||.
pombe   599 QGVSAVQSEAESSAAEMRVYWSFVVGMLTNLGALELERIHNMLTMFIPPPNGYTRTQSELREFLA 663

  Fly   784 RKVREHKLIFSGGVYQL 800
            ..::|.||.|:||.|:|
pombe   664 LMIKEEKLEFTGGAYKL 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mr	NP_611862.1	CULLIN	494..632	CDD:214545	48/137 (35%)
		ANAPC2	741..800	CDD:462556	27/58 (47%)
apc2	NP_001018806.1	CULLIN	410..513	CDD:214545	35/106 (33%)
		ANAPC2	621..680	CDD:462556	27/58 (47%)