Protein Alignment mr and ANAPC2

DIOPT Version :10

• Sequence 1: NP_611862.1
• Gene: mr / 45906
• FlyBaseID: FBgn0002791
• Length: 802
• Species: Drosophila melanogaster
• Sequence 2: NP_037498.1
• Gene: ANAPC2 / 29882
• HGNCID: 19989
• Length: 822
• Species: Homo sapiens
• Alignment Length: 781
• Identity: 293/781 - (37%)
• Similarity: 460/781 - (58%)
• Gaps: 64/781 - (8%)

  Fly    50 FAAVVDLEIQSTIRNVLVPKFWKHIHDGLVSSKLQGWINDQALAIEALPDKNGLFTQFIDA-INE 113
            |..|:..::|:.|.    |:||..|.....|:       |:...:..|.|..||....:|. :..
Human    75 FVEVLQNDLQANIS----PEFWNAISQCENSA-------DEPQCLLLLLDAFGLLESRLDPYLRS 128

  Fly   114 LHDSFQSLMQVKPRLIQLVGAETKPTAKTVKLMQEEGIKNCLRDCLLAQLPPNFSVVVGAFYWVH 178
            |     .|::...||..|:|...:...:.|..|        ||..|....|..|..::...|...
Human   129 L-----ELLEKWTRLGLLMGTGAQGLREEVHTM--------LRGVLFFSTPRTFQEMIQRLYGCF 180

  Fly   179 FKLFTKASNLALTTVDSDVFDEL----------------LCVGCNFEAEQCCCQRLTDMVNKTNM 227
            .:::.::........|.::..||                ||.||:.:.:||.|::..:..::.:.
Human   181 LRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCSSDKQQCWCRQALEQFHQLSQ 245

  Fly   228 KLFEMNLIDRLTGSALTALIKLKIKEHISDTCMGIFDRSHLKQLETWLSDVIMSWLTNIFTEWKS 292
            .|..::|::|::..|:|..:....:|.:.|.|.|.::||.|::...|:..|: .||..:|.:
Human   246 VLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVV-GWLGKVFLQ--- 306

  Fly   293 KDSISDIEVPE---SVKSFKVKLTYFMYETFAQSVIGQFFSIIIDYPDSIPAIDDLKICMEKIDM 354
             |..:....||   :::.::..:..|.|..:|...|.:.|||:.|:|||.|||:|||.|:|:.|.
Human   307 -DGPARPASPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIEDLKYCLERTDQ 370

  Fly   355 RVYLTESLRNSLEARILHPGVNTMDILTGYVAAIKAIRHLDSTGVILEMVTAPIKDYLRKRNDTV 419
            |..|..||:.:||.|:|||||||.||:|.|::||||:|.||.:.||||:...||:.|||.|.|||
Human   371 RQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVACEPIRRYLRTREDTV 435

  Fly   420 RRVVTGLT--EEGPTDLSEELAKGE--TIKECKDSGTDEFSNWENWQPDPFGIDASIMQYNSSRK 480
            |::|.|||  .:|..||:.||:|.:  :::..:|| .|:....|:|.|||...|..    .||.|
Human   436 RQIVAGLTGDSDGTGDLAVELSKTDPASLETGQDS-EDDSGEPEDWVPDPVDADPG----KSSSK 495

  Fly   481 MRSADIISMVVDIYGSKELFMTEYRNLMADRLLAQLDFNSEKEIRNLELLKIRFGESLLHSCEVM 545
            .||:||||::|.|||||:||:.|||:|:|||||.|..|:.|:||||:||||:||||:.:|.||||
Human   496 RRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVM 560

  Fly   546 LKDVTDSKRINAHIHSDGDR---TENQLFDISSLIVSAQFWPSFNKESLQLPEEIENEFKKYTKA 607
            |||:.||:||||:|..:.::   .|...|.:.::|:|::|||.|..|.|::||:|....:.|.|.
Human   561 LKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKK 625

  Fly   608 YEAYKGNRTLNWRTVTGRVNIEIEIGDRTMEMVVSPILAVIIYHFQTKNEWTIEDLSSITKVPAS 672
            ||..|..|||:|:...|.|.:::|:.|||:.:.|:|:.|||:.:||.:..||:|:||...|:|.:
Human   626 YEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVA 690

  Fly   673 ALRRRLSFWQNHGLISETTPGIFTLLEKESEKSQYEDMSLAEADEEDLESAMASASDQREEELQV 737
            .||||:|.|...|::.|..||.|:::|:|..:.: ::|.|.::|:|. :|.|||.:||:||||.:
Human   691 LLRRRMSVWLQQGVLREEPPGTFSVIEEERPQDR-DNMVLIDSDDES-DSGMASQADQKEEELLL 753

  Fly   738 FWSYIVGMLTNLDSMPIDRIHQMLKLFASHSGGV-EFTQDELKHFLQRKVREHKLIFSGGVYQLA 801
            ||:||..|||||:|:.:|||:.||::|......: |....||:.:||:|||:.:|::|.|||:|.
Human   754 FWTYIQAMLTNLESLSLDRIYNMLRMFVVTGPALAEIDLQELQGYLQKKVRDQQLVYSAGVYRLP 818

  Fly   802 K 802
            |
Human   819 K 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mr	NP_611862.1	CULLIN	494..632	CDD:214545	69/140 (49%)
		ANAPC2	741..800	CDD:462556	27/59 (46%)
ANAPC2	NP_037498.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	450..495		16/49 (33%)
		Cullin homology. /evidence=ECO:0000269|PubMed:9469815	502..700		96/197 (49%)
		Cullin	<512..694	CDD:459983	85/181 (47%)
		APC2	757..817	CDD:198081	27/59 (46%)