Protein Alignment mr and Anapc2

DIOPT Version :10

• Sequence 1: NP_611862.1
• Gene: mr / 45906
• FlyBaseID: FBgn0002791
• Length: 802
• Species: Drosophila melanogaster
• Sequence 2: NP_001094002.1
• Gene: Anapc2 / 296558
• RGDID: 1305546
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 806
• Identity: 303/806 - (37%)
• Similarity: 468/806 - (58%)
• Gaps: 67/806 - (8%)

  Fly    28 PVEENV---FQNVRQHLMVLGSIDTFAAVVDLEIQSTIRNVLVPKFWKHIHDGLVSSKLQGWIND 89
            |.||.:   .:.:|.|.:.....:.|..|:..::|..|    ..:||..|       .|:....|
  Rat    64 PKEEELRAAVEVLRAHGLHSVLEEWFVEVLQNDLQGNI----ATEFWNAI-------SLRENSVD 117

  Fly    90 QALAIEALPDKNGLFTQFIDAINELHDSFQSLMQVKPRLIQLVGAETKPTAKTVKLMQEEGIKNC 154
            :...:..|.|..||....:|..  ||.  ..|::...||..|:||..:...:.|..|
  Rat   118 EPQCLVLLLDAFGLLESRLDPY--LHS--LELLEKWTRLGLLMGAGAQGLREKVHTM-------- 170

  Fly   155 LRDCLLAQLPPNFSVVVGAFYWVHFKLFTKASNLALTTVDSDVFDEL----------------LC 203
            ||..|....|..|..:|...|....:::.::........|.::..||                ||
  Rat   171 LRGVLFFSTPRTFQEMVQRLYGRFLRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLC 235

  Fly   204 VGCNFEAEQCCCQRLTDMVNKTNMKLFEMNLIDRLTGSALTALIKLKIKEHISDTCMGIFDRSHL 268
            .||..:.:||.|::..:..|:.:..|..::|::|::..|:|..:....:|.:.|.|.|.::||.|
  Rat   236 AGCGSDKQQCWCRQALEQFNQLSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFL 300

  Fly   269 KQLETWLSDVIMSWLTNIFTEWKSKDSISDIEVPE---SVKSFKVKLTYFMYETFAQSVIGQFFS 330
            ::...|:..|: .||..:|.:    |:.|....||   :::.::..:..|.|..:|...|.:.||
  Rat   301 REFHKWIERVV-GWLGKVFLQ----DNPSRPTSPEAGNTLRRWRCHVQRFFYRIYASLRIEELFS 360

  Fly   331 IIIDYPDSIPAIDDLKICMEKIDMRVYLTESLRNSLEARILHPGVNTMDILTGYVAAIKAIRHLD 395
            ||.|:|||.|||:|||.|:|:.|.|..|..||:.:||.|:|||||||.||:|.|::||||:|.||
  Rat   361 IIRDFPDSRPAIEDLKYCLERTDQRQQLLVSLKVALETRLLHPGVNTCDIITLYISAIKALRVLD 425

  Fly   396 STGVILEMVTAPIKDYLRKRNDTVRRVVTGLT--EEGPTDLSEELAKGETIKECKDSG---TDEF 455
            .:.||||:...||:.|||.|.||||::|.|||  .:|..||:.||:|  |...|.::|   .|:.
  Rat   426 PSMVILEVACEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSK--TDPACLETGQDSEDDS 488

  Fly   456 SNWENWQPDPFGIDASIMQYNSSRKMRSADIISMVVDIYGSKELFMTEYRNLMADRLLAQLDFNS 520
            ...|:|.|||...|.:    .||.|.||:||||::|.|||||:||:.|||:|:|||||.|..|:.
  Rat   489 GEPEDWVPDPVDADPA----KSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSP 549

  Fly   521 EKEIRNLELLKIRFGESLLHSCEVMLKDVTDSKRINAHIHSDGDR---TENQLFDISSLIVSAQF 582
            |:||||:||||:||||:.:|.|||||||:.||:||||:|..:.::   .|...|.:.::|:|::|
  Rat   550 EREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPVEEQPPFGVYAVILSSEF 614

  Fly   583 WPSFNKESLQLPEEIENEFKKYTKAYEAYKGNRTLNWRTVTGRVNIEIEIGDRTMEMVVSPILAV 647
            ||.|..|.|::||:|......|.|.||..|..|||:|:...|.|.:::|:.|||:.:.|:|:.||
  Rat   615 WPPFKDEKLEVPEDIRAALDVYCKKYEKLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAV 679

  Fly   648 IIYHFQTKNEWTIEDLSSITKVPASALRRRLSFWQNHGLISETTPGIFTLLEKESEKSQYEDMSL 712
            ::.:||.:..||:|:||.:.|:|.:.||||:|.|...|::.|..||.|:::|:|..:.: ::|.|
  Rat   680 VLLYFQDQASWTLEELSKVVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEERPQDR-DNMVL 743

  Fly   713 AEADEEDLESAMASASDQREEELQVFWSYIVGMLTNLDSMPIDRIHQMLKLFASHSGGV-EFTQD 776
            .::|:|. :|.|||.:||:||||.:||:||..|||||:|:.::||:.||::|......: |....
  Rat   744 IDSDDES-DSGMASQADQKEEELLLFWTYIQAMLTNLESLSLERIYSMLRMFVMTGPALAEIDLQ 807

  Fly   777 ELKHFLQRKVREHKLIFSGGVYQLAK 802
            ||:.:||:|||:.:||:|.|||:|.|
  Rat   808 ELQGYLQKKVRDQQLIYSAGVYRLPK 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mr	NP_611862.1	CULLIN	494..632	CDD:214545	69/140 (49%)
		ANAPC2	741..800	CDD:462556	27/59 (46%)
Anapc2	NP_001094002.1	Cullin	<526..708	CDD:459983	84/181 (46%)
		APC2	771..831	CDD:198081	27/59 (46%)