DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mr and apc-2

DIOPT Version :9

Sequence 1:	NP_611862.1	Gene:	mr / 45906	FlyBaseID:	FBgn0002791	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_498762.2	Gene:	apc-2 / 176139	WormBaseID:	WBGene00000143	Length:	731	Species:	Caenorhabditis elegans

Alignment Length:	782	Identity:	196/782 - (25%)
Similarity:	338/782 - (43%)	Gaps:	140/782 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 VSSKLQGWINDQALAIEALPDKNGLFTQFIDAINELHDSFQSLMQVKPRLIQL-----VG-AETK 137
            ||.|.:.|   .||...|...||         |.:::|....|.:|:...:..     || .:.:
Worm    22 VSKKKEVW---DALIYHAKYAKN---------IEKVYDMTTVLQRVQQECLMFALEKGVGQPDIR 74

  Fly   138 PTAKTV--KLMQEEGIKNCLRDCLLAQLPPNFSVVVGAFYWVHFKLFTKASNLALTTVDS--DVF 198
            ..|:.:  ..||:..||                 |:..::..||..:..|..|....:|.  |:.
Worm    75 DAAELIFPLAMQKVVIK-----------------VLRPYFMSHFTNYRLAMYLPHRKIDHGIDLN 122

  Fly   199 DELLCVGCNFEAEQCCCQRLTD---MVNKTNMKLFEMNLIDRLTGSALTALIKLKIKEHISDTCM 260
            .||...    |.::.|.|.:.|   .||:....:...|       ..:.|.:.:.|:|..:...|
Worm   123 QELWTP----EKKEICGQYVQDFNPFVNELKTGILNAN-------RHMNAALSVYIRELAATLVM 176

  Fly   261 ---GIFD--------RSHLKQLETWLSDVIMSWLTNIFTEWKSKDSISDIEVPESVKSFKVKLTY 314
               ..||        :..::.|..|...|.|....::.::...||          |.....|..|
Worm   177 HEKAAFDNELRCSMFQEIMESLRIWSDQVTMQDAFHLISDTIYKD----------VFQMLSKNAY 231

  Fly   315 FMYETFAQSVIGQFFSIIIDYPDSIPAIDDLKICMEKIDM--RVYLTESLRNSLEARILHPGVNT 377
            .|              |.:|:|....::..:|.|:.:.:.  ||..|..|.:.:..::|...|:|
Worm   232 EM--------------IAVDFPVKFRSLITMKYCLLRTNNHGRVDFTNYLIDQVNTKLLVASVDT 282

  Fly   378 MDILTGYVAAIKAIRHLDSTGVILEMVTAPIKDYLRKRNDTVRRVVTGLTEEGPTDLSEELA-KG 441
            .|||..|.|.::::|.:|::.|::..|...|::||::|.|||:::::.:|.....:|.:::: :.
Worm   283 KDILKAYAACVESLREMDNSCVVMHKVCGVIREYLKRRPDTVQQIISYITSNKKNELEKDMSLQS 347

  Fly   442 ETIK-------ECKDSGTD------EFSNWENWQPDPFGIDASIMQYNSSRKMRSADIISMVVDI 493
            :|::       |.|....|      |...||||.|:|  .||::  .:.:...:..|:.:|:|.:
Worm   348 KTVRSAMMDEEELKGVNDDFLPENMETLGWENWMPNP--TDATV--GDGAPGHQGVDVFNMLVSV 408

  Fly   494 YGSKELFMTEYRNLMADRLLAQLDFNSEKEIRNLELLKIRFGESLLHSCEVMLKDVTDSKRINAH 558
            |||||||:.|||||:|:||.:..:.:.|.|.|.|:|||:||..|.|..|||||:||..|..|:..
Worm   409 YGSKELFVKEYRNLLAERLSSSDNKDPEFEKRYLDLLKLRFQYSELQHCEVMLRDVIHSLDIDKK 473

  Fly   559 IHSDGDRTENQ----LFDISSLIVSAQFWPSFNKESLQ--LPEEIENEFKKYTKAYEAYKGNRTL 617
            .....:|:...    :..||:.|:|:.:||....|..:  :|:.::.....|.:.|...|.:|.|
Worm   474 FEDMSERSAGNYDVPIIPISACIISSHYWPKLETEKTEALMPQPLQAAMDVYQETYLDVKRDRKL 538

  Fly   618 NWRTVTGRVNIEIEIGDRTMEMVVSPILAVIIYHFQTKNEWTIEDLSSITKVPASALRRRLSFWQ 682
            .|....|.|.:.|.|....::..:..:.|::::.|..|..||..::.....:.....|:||.:..
Worm   539 EWLRSVGCVEVSINIDGVEVDRTIPNMYALLLFLFLEKETWTTAEVVEKMGMSVVVTRKRLEWLV 603

  Fly   683 NHG------LISETTPGIFTLLEKESEKSQYEDMSLAEADEEDLE----SAMASASDQREEELQV 737
            ..|      :||..|   :||....|..|.....:....|:||:|    |.|..|.:|
Worm   604 KQGFICMNPIISSDT---WTLTRNPSGISIVRPGTPDLEDDEDVEPEENSDMVDALEQ------- 658

  Fly   738 FWSYIVGMLTN---LDSMPIDRIHQMLKLFAS-HSGGVEFTQDELKHFLQRKVREHKLIFSGGVY 798
            :|.|....:.|   ...:..:|:|::.::|.| .|.|.  |.|.:..||||||....|....|.|
Worm   659 YWGYTRNFIANHAPNGEVKAERMHRVYRMFGSPTSAGP--TLDHVSAFLQRKVALGLLTCINGSY 721

  Fly   799 QL 800
            ::
Worm   722 RI 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mr	NP_611862.1	CULLIN	494..632	CDD:214545	53/143 (37%)
mr	NP_611862.1	APC2	741..800	CDD:198081	19/62 (31%)
apc-2	NP_498762.2	CULLIN	408..553	CDD:214545	53/144 (37%)
apc-2	NP_498762.2	APC2	662..723	CDD:198081	19/62 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160098
Domainoid	1	1.000	103	1.000	Domainoid score	I4260
eggNOG	1	0.900	-	-		E1_KOG2165
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	199	1.000	Inparanoid score	I2483
Isobase	1	0.950	-	0	Normalized mean entropy	S3734
OMA	1	1.010	-	-		QHG56055
OrthoDB	1	1.010	-	-		D182834at33208
OrthoFinder	1	1.000	-	-		FOG0005254
OrthoInspector	1	1.000	-	-		oto20218
orthoMCL	1	0.900	-	-		OOG6_103028
Panther	1	1.100	-	-	LDO	PTHR45957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R69
SonicParanoid	1	1.000	-	-		X4265
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750