DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mr and anapc2

DIOPT Version :9

Sequence 1:	NP_611862.1	Gene:	mr / 45906	FlyBaseID:	FBgn0002791	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_031746476.1	Gene:	anapc2 / 101731339	XenbaseID:	XB-GENE-491168	Length:	811	Species:	Xenopus tropicalis

Alignment Length:	810	Identity:	318/810 - (39%)
Similarity:	480/810 - (59%)	Gaps:	100/810 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 HLMVLGSI--DTFAAVVDLEIQSTIRNVLVPKFWKHIHDGLVSSKLQGWINDQALAIEALPDKNG 102
            ||..|.|:  :.|..|:.:::|   ||: .|:||                             ||
Frog    52 HLYDLHSMVEEWFTEVLQMDLQ---RNI-APEFW-----------------------------NG 83

  Fly   103 LFTQFIDAINELH------DSFQSLM-QVKPRL----IQLVGAETKPTAKTVKLMQEEGIKNCLR 156
            : .|..:|:.|.|      |:|:.|: :::|.|    |.....:|.....:...|..:.:....:
Frog    84 I-NQHENAVEEEHCAVLLLDAFRLLVSRLEPYLRSLDILAKWIDTGLLGSSDSQMLRDKVYTMFK 147

  Fly   157 DCLLAQLPPNFSVVVGAFYWVHFKLFTK---------------ASNLALTTVDSDV--FDELLCV 204
            ..|......:|..::..||...||::.|               :.|......|||.  .||..|.
Frog   148 AILFFSTSSHFQDMIQQFYSRTFKIYMKQRKRGDGGGGGGSDSSMNENERESDSDERGADEWQCP 212

  Fly   205 GCNFEAEQCCC-------QRLTDMVNKTNMKLFEMNLIDRLTGSALTALIKLKIKEHISDTCMGI 262
            ||....:||.|       |:|:|:.::       :||::|:...|:|.::...|:|.:...|.|.
Frog   213 GCESSRDQCWCLCAMGQFQQLSDIFHR-------LNLLERICSDAVTTILHKMIEERMEKRCRGE 270

  Fly   263 FDRSHLKQLETWLSDVIMSWLTNIFTEWKSKDSISDIEVPE---SVKSFKVKLTYFMYETFAQSV 324
            ::||.|.:.:.|:..|| .||:.:|.:    |.......||   ::|.::..:..|.|..:|...
Frog   271 YERSFLGEFQEWIEKVI-GWLSKVFLQ----DGTVPPTTPETSSTLKRWRCHVQRFFYRLYASMR 330

  Fly   325 IGQFFSIIIDYPDSIPAIDDLKICMEKIDMRVYLTESLRNSLEARILHPGVNTMDILTGYVAAIK 389
            |.:.|:||.|:|:|.|||:|||.|:|:.:.|..|..||:|:||.|:|||||||.||:|.|::|||
Frog   331 IEELFNIIRDFPESKPAIEDLKFCLERTNQRQQLLTSLKNALETRLLHPGVNTSDIITLYISAIK 395

  Fly   390 AIRHLDSTGVILEMVTAPIKDYLRKRNDTVRRVVTGLT--EEGPTDLSEELAKGETIKECKDSGT 452
            |:|.||.:.||||:...||:.|||.|.||||::|.|||  .||..||:.||:|.:.:.|......
Frog   396 ALRELDPSMVILEVACEPIRKYLRTREDTVRQIVAGLTGDAEGSADLANELSKADPVLENGQESD 460

  Fly   453 DEFSNWENWQPDPFGIDASIMQYNSSRKMRSADIISMVVDIYGSKELFMTEYRNLMADRLLAQLD 517
            |:.|..|:|.|||...|..    .||.|.||:||||::|.||||||||:.|||.|:|:|||.|.:
Frog   461 DDVSEAEDWLPDPVDADPG----KSSSKRRSSDIISLLVSIYGSKELFINEYRTLLAERLLHQFN 521

  Fly   518 FNSEKEIRNLELLKIRFGESLLHSCEVMLKDVTDSKRINAHIHSDGDR---TENQLFDISSLIVS 579
            ::||:||||:||||:||||:.:|.|||||||:.||:|||::|..:.::   .|...|::.::|:|
Frog   522 YSSEREIRNVELLKLRFGEAQMHYCEVMLKDMADSRRINSNIRDEEEKLPEEERPPFNVVAVILS 586

  Fly   580 AQFWPSFNKESLQLPEEIENEFKKYTKAYEAYKGNRTLNWRTVTGRVNIEIEIGDRTMEMVVSPI 644
            ::|||:..:|.|:||:||:.....|||.||..|..|||||:...|.|.:::|:.|||:...|||:
Frog   587 SEFWPALKEEKLELPDEIKEVMDMYTKKYEKLKAMRTLNWKHHLGLVVLDVELADRTLSFPVSPV 651

  Fly   645 LAVIIYHFQTKNEWTIEDLSSITKVPASALRRRLSFWQNHGLISETTPGIFTLLEKESEKSQYED 709
            .|.||.|||.|:.||:|:||.:.|||.::||::::||..||::.|..||.||::|:| :|.:.|.
Frog   652 HAAIILHFQNKSTWTLEELSEVLKVPVASLRKKMAFWLQHGVLREDPPGTFTVIEEE-QKDRPEK 715

  Fly   710 MSLAEADEEDLESAMASASDQREEELQVFWSYIVGMLTNLDSMPIDRIHQMLKLFASHSGGV--E 772
            :.|.::|||. :|||||.:||:|||:|:||:||..|||||:|:|::|||.|||:|.. :|.|  |
Frog   716 VVLIDSDEEG-DSAMASQADQKEEEMQLFWTYIQAMLTNLESLPLERIHTMLKMFVM-TGPVVTE 778

  Fly   773 FTQDELKHFLQRKVREHKLIFSGGVYQLAK 802
            ....||:.|||:||.:|:|::|||||:|.|
Frog   779 IDIQELQSFLQKKVSDHQLVYSGGVYRLPK 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mr	NP_611862.1	CULLIN	494..632	CDD:214545	70/140 (50%)
mr	NP_611862.1	APC2	741..800	CDD:198081	33/60 (55%)
anapc2	XP_031746476.1	CULLIN	498..635	CDD:214545	70/136 (51%)
anapc2	XP_031746476.1	ANAPC2	746..806	CDD:400832	33/60 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	209	1.000	Domainoid score	I2790
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8359
Inparanoid	1	1.050	539	1.000	Inparanoid score	I1163
OMA	1	1.010	-	-		QHG56055
OrthoDB	1	1.010	-	-		D182834at33208
OrthoFinder	1	1.000	-	-		FOG0005254
OrthoInspector	1	1.000	-	-		oto103962
Panther	1	1.100	-	-	LDO	PTHR45957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R69
SonicParanoid	1	1.000	-	-		X4265
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110