Protein Alignment mr and anapc2

DIOPT Version :10

• Sequence 1: NP_611862.1
• Gene: mr / 45906
• FlyBaseID: FBgn0002791
• Length: 802
• Species: Drosophila melanogaster
• Sequence 2: XP_031746476.1
• Gene: anapc2 / 101731339
• XenbaseID: XB-GENE-491168
• Length: 811
• Species: Xenopus tropicalis
• Alignment Length: 810
• Identity: 318/810 - (39%)
• Similarity: 480/810 - (59%)
• Gaps: 100/810 - (12%)

  Fly    40 HLMVLGSI--DTFAAVVDLEIQSTIRNVLVPKFWKHIHDGLVSSKLQGWINDQALAIEALPDKNG 102
            ||..|.|:  :.|..|:.:::|   ||: .|:||                             ||
 Frog    52 HLYDLHSMVEEWFTEVLQMDLQ---RNI-APEFW-----------------------------NG 83

  Fly   103 LFTQFIDAINELH------DSFQSLM-QVKPRL----IQLVGAETKPTAKTVKLMQEEGIKNCLR 156
            : .|..:|:.|.|      |:|:.|: :::|.|    |.....:|.....:...|..:.:....:
 Frog    84 I-NQHENAVEEEHCAVLLLDAFRLLVSRLEPYLRSLDILAKWIDTGLLGSSDSQMLRDKVYTMFK 147

  Fly   157 DCLLAQLPPNFSVVVGAFYWVHFKLFTK---------------ASNLALTTVDSDV--FDELLCV 204
            ..|......:|..::..||...||::.|               :.|......|||.  .||..|.
 Frog   148 AILFFSTSSHFQDMIQQFYSRTFKIYMKQRKRGDGGGGGGSDSSMNENERESDSDERGADEWQCP 212

  Fly   205 GCNFEAEQCCC-------QRLTDMVNKTNMKLFEMNLIDRLTGSALTALIKLKIKEHISDTCMGI 262
            ||....:||.|       |:|:|:.::       :||::|:...|:|.::...|:|.:...|.|.
 Frog   213 GCESSRDQCWCLCAMGQFQQLSDIFHR-------LNLLERICSDAVTTILHKMIEERMEKRCRGE 270

  Fly   263 FDRSHLKQLETWLSDVIMSWLTNIFTEWKSKDSISDIEVPE---SVKSFKVKLTYFMYETFAQSV 324
            ::||.|.:.:.|:..|| .||:.:|.:    |.......||   ::|.::..:..|.|..:|...
 Frog   271 YERSFLGEFQEWIEKVI-GWLSKVFLQ----DGTVPPTTPETSSTLKRWRCHVQRFFYRLYASMR 330

  Fly   325 IGQFFSIIIDYPDSIPAIDDLKICMEKIDMRVYLTESLRNSLEARILHPGVNTMDILTGYVAAIK 389
            |.:.|:||.|:|:|.|||:|||.|:|:.:.|..|..||:|:||.|:|||||||.||:|.|::|||
 Frog   331 IEELFNIIRDFPESKPAIEDLKFCLERTNQRQQLLTSLKNALETRLLHPGVNTSDIITLYISAIK 395

  Fly   390 AIRHLDSTGVILEMVTAPIKDYLRKRNDTVRRVVTGLT--EEGPTDLSEELAKGETIKECKDSGT 452
            |:|.||.:.||||:...||:.|||.|.||||::|.|||  .||..||:.||:|.:.:.|......
 Frog   396 ALRELDPSMVILEVACEPIRKYLRTREDTVRQIVAGLTGDAEGSADLANELSKADPVLENGQESD 460

  Fly   453 DEFSNWENWQPDPFGIDASIMQYNSSRKMRSADIISMVVDIYGSKELFMTEYRNLMADRLLAQLD 517
            |:.|..|:|.|||...|..    .||.|.||:||||::|.||||||||:.|||.|:|:|||.|.:
 Frog   461 DDVSEAEDWLPDPVDADPG----KSSSKRRSSDIISLLVSIYGSKELFINEYRTLLAERLLHQFN 521

  Fly   518 FNSEKEIRNLELLKIRFGESLLHSCEVMLKDVTDSKRINAHIHSDGDR---TENQLFDISSLIVS 579
            ::||:||||:||||:||||:.:|.|||||||:.||:|||::|..:.::   .|...|::.::|:|
 Frog   522 YSSEREIRNVELLKLRFGEAQMHYCEVMLKDMADSRRINSNIRDEEEKLPEEERPPFNVVAVILS 586

  Fly   580 AQFWPSFNKESLQLPEEIENEFKKYTKAYEAYKGNRTLNWRTVTGRVNIEIEIGDRTMEMVVSPI 644
            ::|||:..:|.|:||:||:.....|||.||..|..|||||:...|.|.:::|:.|||:...|||:
 Frog   587 SEFWPALKEEKLELPDEIKEVMDMYTKKYEKLKAMRTLNWKHHLGLVVLDVELADRTLSFPVSPV 651

  Fly   645 LAVIIYHFQTKNEWTIEDLSSITKVPASALRRRLSFWQNHGLISETTPGIFTLLEKESEKSQYED 709
            .|.||.|||.|:.||:|:||.:.|||.::||::::||..||::.|..||.||::|:| :|.:.|.
 Frog   652 HAAIILHFQNKSTWTLEELSEVLKVPVASLRKKMAFWLQHGVLREDPPGTFTVIEEE-QKDRPEK 715

  Fly   710 MSLAEADEEDLESAMASASDQREEELQVFWSYIVGMLTNLDSMPIDRIHQMLKLFASHSGGV--E 772
            :.|.::|||. :|||||.:||:|||:|:||:||..|||||:|:|::|||.|||:|.. :|.|  |
 Frog   716 VVLIDSDEEG-DSAMASQADQKEEEMQLFWTYIQAMLTNLESLPLERIHTMLKMFVM-TGPVVTE 778

  Fly   773 FTQDELKHFLQRKVREHKLIFSGGVYQLAK 802
            ....||:.|||:||.:|:|::|||||:|.|
 Frog   779 IDIQELQSFLQKKVSDHQLVYSGGVYRLPK 808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mr	NP_611862.1	CULLIN	494..632	CDD:214545	70/140 (50%)
		ANAPC2	741..800	CDD:462556	33/60 (55%)
anapc2	XP_031746476.1	CULLIN	498..635	CDD:214545	70/136 (51%)
		APC2	746..806	CDD:198081	33/60 (55%)