DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mr and anapc2

DIOPT Version :9

Sequence 1:	NP_611862.1	Gene:	mr / 45906	FlyBaseID:	FBgn0002791	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001243675.1	Gene:	anapc2 / 100318335	ZFINID:	ZDB-GENE-081104-256	Length:	802	Species:	Danio rerio

Alignment Length:	832	Identity:	302/832 - (36%)
Similarity:	466/832 - (56%)	Gaps:	96/832 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AVSNDPVEENVFQNVRQHLMVLGSI-DTFAAVVD-----------LE-IQSTIRNVLVPKFWKHI 74
            :|:.|.|..::...|:|::....:: |..:.:.:           || :|..:...:.|:||
Zfish    12 SVAWDTVTSSLVSPVQQNVSTAEALSDALSLLTEHGLGQYVEGWLLETLQVRLTTSVAPEFW--- 73

  Fly    75 HDGLVSSKLQGWINDQALAIEALPDKNGLFTQFIDAINELHDSFQSLMQVKPRL--IQLVGAETK 137
             .||...:......|:|.|:             :||...|      |.|::|.|  ::.:|:
Zfish    74 -TGLKQPEGDSQERDRAKAL-------------LDAFRNL------LQQLEPFLGGLEKLGS--- 115

  Fly   138 PTAKTVKLMQEEGIKN-C--------------LRDCLLAQLPPNFSVVVGAFY----WVHFKLFT 183
                    .|||...: |              :|..||...||.....:..||    .||.....
Zfish   116 --------WQEESCGDLCGPGPHGLIERAFSVIRAILLFSPPPVLQERMLEFYSRTFSVHMSQAG 172

  Fly   184 KASNLALTTVDSDVFDELLCVGCNFEAEQCCCQRLTDMVNKTNMKLFEMNLIDRLTGSALTALIK 248
            :|.......||:|  :..||.||......|.||.....:.:.:..|..:.|::|::..|:|:::.
Zfish   173 EAVEAEEGAVDTD--EGGLCSGCATLPHLCWCQEALQQLQELSHILSRLQLLERVSSEAVTSILH 235

  Fly   249 LKIKEHISDTCMGIFDRSHLKQLETWLSDVIMSWLTNIFTEWKSKDSISDIEVPES--------- 304
            ..|::.:.....|.::||.|.....||..| :.||:.:|:. |:.:..|:|...:.
Zfish   236 QLIEQRMEQRYRGEYERSFLTDFNDWLGQV-LGWLSRVFSS-KADEVGSEITPIDGKMGQPANAL 298

  Fly   305 VKSFKVKLTYFMYETFAQSVIGQFFSIIIDYPDSIPAIDDLKICMEKIDMRVYLTESLRNSLEAR 369
            ::.:...:..|....:....|.:.||||.|:|:|.|||:|||.|:|:.:.|..|..||:::.|.|
Zfish   299 LQRWHCHMHQFFCRIYVNMRIEELFSIIRDFPESTPAIEDLKFCLERTNQRQQLLASLKSAFETR 363

  Fly   370 ILHPGVNTMDILTGYVAAIKAIRHLDSTGVILEMVTAPIKDYLRKRNDTVRRVVTGLT--EEGPT 432
            :|||||:|.||:|.|::||||:|.||.:.|||::...||:.|||.|.||||::|..||  .||.|
Zfish   364 LLHPGVHTSDIITVYISAIKALRELDPSMVILQVACQPIRKYLRTREDTVRQIVGSLTGDSEGCT 428

  Fly   433 DLSEELAKGETIK-ECKDSGTDEFSNWENWQPDPFGIDASIMQYNSSRKMRSADIISMVVDIYGS 496
            ||:.||::.:.:. |.:|| .||.|:.|:|.|||  .||  :...:..|.||:||||::|.||||
Zfish   429 DLANELSRADPVALETQDS-EDEGSDPEDWTPDP--TDA--LTDKTGSKRRSSDIISLLVSIYGS 488

  Fly   497 KELFMTEYRNLMADRLLAQLDFNSEKEIRNLELLKIRFGESLLHSCEVMLKDVTDSKRINAHIHS 561
            ||:|:.||:.::|||||.||::|:.:||||:||||:|||||.:|.||||||||.||:|||::||.
Zfish   489 KEIFVNEYKTVLADRLLHQLNYNTAREIRNVELLKLRFGESHMHYCEVMLKDVADSRRINSNIHE 553

  Fly   562 DGDR---TENQLFDISSLIVSAQFWPSFNKESLQLPEEIENEFKKYTKAYEAYKGNRTLNWRTVT 623
            :..|   .|.....:|::|:|::|||...:|.::||.......:.||..:|..|..|||.|:...
Zfish   554 EERRLPAEEQPTLPLSAMIISSEFWPQLKEEKMELPAVASKAMEDYTHRFEKLKAMRTLRWKPQL 618

  Fly   624 GRVNIEIEIGDRTM-EMVVSPILAVIIYHFQTKNEWTIEDLSSITKVPASALRRRLSFWQNHGLI 687
            |.|.:::|:.|||: ::.||||.|.||.|||.|..||:|:||.:..||...:||:|:.||..|::
Zfish   619 GSVTLDLELEDRTITDLTVSPIHAAIILHFQDKGTWTLEELSGVLGVPQEMVRRKLALWQQQGVL 683

  Fly   688 SETTPGIFTLLEKESEKSQYE-DMSLAEADEEDLESAMASASDQREEELQVFWSYIVGMLTNLDS 751
            .|...|.:|:.|..:.|.:.| .:.|.::|||. :|..|:.|:||||:||:||:||..|||||:|
Zfish   684 REEAGGRYTVQETSTCKERSERSVMLIDSDEEG-DSNTATQSEQREEKLQLFWAYIQAMLTNLES 747

  Fly   752 MPIDRIHQMLKLFASHSGGV-EFTQDELKHFLQRKVREHKLIFSGGVYQLAK 802
            |.::|||.||::|.:...|| |...:||:.|||:|||.|:|..|.|||:|.|
Zfish   748 MTLERIHSMLRMFVAAGPGVTEMDVNELQAFLQKKVRAHQLTVSTGVYRLPK 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mr	NP_611862.1	CULLIN	494..632	CDD:214545	66/140 (47%)
mr	NP_611862.1	APC2	741..800	CDD:198081	32/59 (54%)
anapc2	NP_001243675.1	CULLIN	486..621	CDD:214545	65/134 (49%)
anapc2	NP_001243675.1	APC2	737..797	CDD:198081	32/59 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582154
Domainoid	1	1.000	188	1.000	Domainoid score	I3260
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8359
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1456
OMA	1	1.010	-	-		QHG56055
OrthoDB	1	1.010	-	-		D182834at33208
OrthoFinder	1	1.000	-	-		FOG0005254
OrthoInspector	1	1.000	-	-		oto39226
orthoMCL	1	0.900	-	-		OOG6_103028
Panther	1	1.100	-	-	LDO	PTHR45957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4265
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910