Protein Alignment lds and CHD1

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_011091.1
• Gene: CHD1 / 856911
• SGDID: S000000966
• Length: 1468
• Species: Saccharomyces cerevisiae
• Alignment Length: 1093
• Identity: 241/1093 - (22%)
• Similarity: 416/1093 - (38%)
• Gaps: 306/1093 - (27%)

  Fly     2 SSENSEYYSDKEEDSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSET 66
            ::....|::|.:::...:|....|.::.:.:....               ||.:.||.|..|.|.
Yeast    26 AAHQQNYFNDSDDEDDEDNIKQSRRKRMTTIEDDE---------------DEFEDEEGEEDSGED 75

  Fly    67 AESEKSDESDNSQNSQESEDSEDDSVRPSARNTKRKPLGIPSDSEDEEDELEQRALSPSTRMSIT 131
            .:.|..:|.|:...|...::..    :|.:| ||.|....|. |:.|:....:.....|.|.:.|
Yeast    76 EDEEDFEEDDDYYGSPIKQNRS----KPKSR-TKSKSKSKPK-SQSEKQSTVKIPTRFSNRQNKT 134

  Fly   132 GVRPQDLSDDD---SEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQ-NDLHSTIGAADSEVL 192
            .....|.||||   ||.:|..|           ||:......:.:.|.| .|.|
Yeast   135 VNYNIDYSDDDLLESEDDYGSE-----------EALSEENVHEASANPQPEDFH----------- 177

  Fly   193 DDSSGSDVLILSNKETPIE---ILSSTDDDATTNKENMSGPPFERPSK---------SLSPRSSA 245
                |.|::|....:|.:|   :|..|..|....|||     :|...|         :.....|.
Yeast   178 ----GIDIVINHRLKTSLEEGKVLEKTVPDLNNCKEN-----YEFLIKWTDESHLHNTWETYESI 233

  Fly   246 GASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAE 310
            |.  |:..|.|.....|.:::.:.....|   .:.:||.:::     |.|..:..::..:....|
Yeast   234 GQ--VRGLKRLDNYCKQFIIEDQQVRLDP---YVTAEDIEIM-----DMERERRLDEFEEFHVPE 288

  Fly   311 KLFEKVAHKLPDKGSQIMKRIDTLRRELAMDE-QWISALRVQQSNVPAVRVVKPTLNPPRAPSID 374
            ::.:.....|.|..||:...:..  |.|..|| .|.:          |..:||  |.|.:.....
Yeast   289 RIIDSQRASLEDGTSQLQYLVKW--RRLNYDEATWEN----------ATDIVK--LAPEQVKHFQ 339

  Fly   375 TLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLK-VS 438
                   :...::|.|.|:     :.:.:|:                 |..|.|:..|..:| ..
Yeast   340 -------NRENSKILPQYS-----SNYTSQR-----------------PRFEKLSVQPPFIKGGE 375

  Fly   439 LMNHQKHALAWMS--WRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSE 501
            |.:.|...:.||:  |.:..   .|||||:||||||:..::.:
Yeast   376 LRDFQLTGINWMAFLWSKGD---NGILADEMGLGKTVQTVAFI---------------------- 415

  Fly   502 DDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGN------ 560
                       .|....|:  :.|..::|.|.|.:..|....| |.:.....:| :.||
Yeast   416 -----------SWLIFARR--QNGPHIIVVPLSTMPAWLDTFE-KWAPDLNCIC-YMGNQKSRDT 465

  Fly   561 --------NRETKGKYLRDYDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSL 617
                    |...|||....:::::|||:.:.::...|.:   :||:.:.:||||.::|.:|....
Yeast   466 IREYEFYTNPRAKGKKTMKFNVLLTTYEYILKDRAELGS---IKWQFMAVDEAHRLKNAESSLYE 527

  Fly   618 AVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQNR-----LNL 677
            ::...:...|..:||||:||...::.||:.||....|    |..:.||.::...:..     |:.
Yeast   528 SLNSFKVANRMLITGTPLQNNIKELAALVNFLMPGRF----TIDQEIDFENQDEEQEEYIHDLHR 588

  Fly   678 LMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERE 742
            .::..:|||.|..::     .|||:|..|::.:.|...:...|:.::|.
Yeast   589 RIQPFILRRLKKDVE-----KSLPSKTERILRVELSDVQTEYYKNILTK---------------- 632

  Fly   743 TDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSH-DILVLLLRLRQICCHPGLID 806
               ||.                         |..||:|   ..| .:|.::..|::...||.|.|
Yeast   633 ---NYS-------------------------ALTAGAK---GGHFSLLNIMNELKKASNHPYLFD 666

  Fly   807 AMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKA 871
                                                          ||         :|..:.|.
Yeast   667 ----------------------------------------------NA---------EERVLQKF 676

  Fly   872 SKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATL 936
            ....:.|.|.:..|...|.|:.::.|:|  :.||....:.::.||...:||||.|:||..|:...
Yeast   677 GDGKMTRENVLRGLIMSSGKMVLLDQLL--TRLKKDGHRVLIFSQMVRMLDILGDYLSIKGINFQ 739

  Fly   937 SLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDR 1001
            .|:||:|...|:..::.||..::...|.|||..|||:|:||:.|:.:::.|..||||.:.||..|
Yeast   740 RLDGTVPSAQRRISIDHFNSPDSNDFVFLLSTRAGGLGINLMTADTVVIFDSDWNPQADLQAMAR 804

  Fly  1002 IYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDL-----ADGVLTGAKVSSK 1049
            .:|:|||.:|::|:.:..||||:.:.....||:.|     :.||..|.|.:.|
Yeast   805 AHRIGQKNHVMVYRLVSKDTVEEEVLERARKKMILEYAIISLGVTDGNKYTKK 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	174/782 (22%)
		DEXHc_TTF2	439..686	CDD:350830	61/267 (23%)
CHD1	NP_011091.1	CD1_tandem_CHD1_yeast_like	175..247	CDD:349312	20/93 (22%)
		CD2_tandem_ScCHD1_like	283..341	CDD:349311	15/78 (19%)
		PLN03142	363..>961	CDD:215601	155/651 (24%)
		Cdh1_DBD_1	1010..1129	CDD:408024
		SANT_TRF	1175..>1204	CDD:212558
		DUF4208	1368..1460	CDD:464035