Protein Alignment lds and MOT1

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_015243.1
• Gene: MOT1 / 856023
• SGDID: S000006003
• Length: 1867
• Species: Saccharomyces cerevisiae
• Alignment Length: 1164
• Identity: 260/1164 - (22%)
• Similarity: 453/1164 - (38%)
• Gaps: 297/1164 - (25%)

  Fly     6 SEYYSDKEEDSVVNNSSLGR-----------SRKSSRLSKSSRLS---------KSSRPSSAGVV 50
            ||.:|     .|:|...|.|           |.|:.|....|.|:         :...|:.|.||
Yeast   787 SEIFS-----PVMNKQLLNRDEFPVFRELVPSLKALRTQCQSLLATFVDVGMLPQYKLPNVAIVV 846

  Fly    51 IDETQSEEEESQSSETAE---SEKSDESDNSQNS-------QESEDSED------DSVRPSARNT 99
            ..||:: ...:...||||   .|..|:...|.|:       :..|||:.      :|.:.||:..
Yeast   847 QGETEA-GPHAFGVETAEKVYGEYYDKMFKSMNNSYKLLAKKPLEDSKHRVLMAINSAKESAKLR 910

  Fly   100 KRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQ--EGPTEAPTAE 162
            ....|...:.|....|.|..: |:|..|..:..|:.          |.::::|  .|.:.....:
Yeast   911 TGSILANYASSILLFDGLPLK-LNPIIRSLMDSVKE----------ERNEKLQTMAGESVVHLIQ 964

  Fly   163 AVVPRYTTQFAGNIQNDLHSTIGAADSEVLDDSSGSDVLILSNKETPIEILSSTDDDATTNKENM 227
            .::.......:|.|..:|...:....|||.|.|..::.     ||..:.::..::..|..:..|:
Yeast   965 QLLENNKVNVSGKIVKNLCGFLCVDTSEVPDFSVNAEY-----KEKILTLIKESNSIAAQDDINL 1024

  Fly   228 SGPPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVY 292
            :     :.|:....:...|...:|....:..|:|...|.|..|......|..::|:...|.
Yeast  1025 A-----KMSEEAQLKRKGGLITLKILFEVLGPSILQKLPQLRSILFDSLSDHENEEASKVD---- 1080

  Fly   293 DEEMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKR----IDTLRRELAM----------DEQ 343
            :|:.:|:.:   .......||..::..|  :.|::..|    :..||..|::          |..
Yeast  1081 NEQGQKIVD---SFGVLRALFPFMSDSL--RSSEVFTRFPVLLTFLRSNLSVFRYSAARTFADLA 1140

  Fly   344 WISALRVQQSNVPAVRVVKPTLN-----PPRAPSID-------TLDWDELSEAVNEIKPVYTGAQ 396
            .||::.|.   ...:|.:.|.:|     ..|..|.:       :::.|.|...:..|.|:.
Yeast  1141 KISSVEVM---AYTIREILPLMNSAGSLSDRQGSTELIYHLSLSMETDVLPYVIFLIVPLL---- 1198

  Fly   397 GMATFNNQKALTLES--------LKDLHVSLEDLPG-PEVLAED--------------------- 431
            |..:.:|:....|.:        |..|...:.|..| ||.|...
Yeast  1199 GRMSDSNEDVRNLATTTFASIIKLVPLEAGIADPKGLPEELVASRERERDFIQQMMDPSKAKPFK 1263

  Fly   432 -PVGLKVSLMNHQKHALAWMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDES 495
             |:.:|.:|..:|:..:.|:::. .|....|||.|||||||||..|..:               :
Yeast  1264 LPIAIKATLRKYQQDGVNWLAFL-NKYHLHGILCDDMGLGKTLQTICII---------------A 1312

  Fly   496 SDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGN 560
            ||.....:..:|.:||         ::|...:|::||.||...||:|.:......|:.|......
Yeast  1313 SDQYLRKEDYEKTRSV---------ESRALPSLIICPPSLTGHWENEFDQYAPFLKVVVYAGGPT 1368

  Fly   561 NRETKGKYLRDYDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGK 625
            .|.|....|.|.||:||:|.:...:   |:.:...::...:|||.|:::|.:|:.:.||.::...
Yeast  1369 VRLTLRPQLSDADIIVTSYDVARND---LAVLNKTEYNYCVLDEGHIIKNSQSKLAKAVKEITAN 1430

  Fly   626 YRWALTGTPIQNKELDVYALLKFLR--------------CSPFDDLHTWKKWIDNKSAG--GQNR 674
            :|..||||||||..|::::|..||.              ..|.......|.....:.||  ....
Yeast  1431 HRLILTGTPIQNNVLELWSLFDFLMPGFLGTEKMFQERFAKPIAASRNSKTSSKEQEAGVLALEA 1495

  Fly   675 LNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQR- 738
            |:..:...||||.|..:.||     ||.|.::           :.|..:....:.|:..|..::
Yeast  1496 LHKQVLPFMLRRLKEDVLSD-----LPPKIIQ-----------DYYCELGDLQKQLYMDFTKKQK 1544

  Fly   739 --AERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCH 801
              .|::.:.:..:|.                                |.| |...|..:|::|.|
Yeast  1545 NVVEKDIENSEIADG--------------------------------KQH-IFQALQYMRKLCNH 1576

  Fly   802 PGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPL----- 861
            |.|:                   .:|....|||:... :..|..| ...:.||    |.|
Yeast  1577 PALV-------------------LSPNHPQLAQVQDY-LKQTGLD-LHDIINA----PKLSALRT 1616

  Fly   862 ------LPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSV 920
                  :.:|....|||::   ::.|:.|:                    .|..:|::..|...:
Yeast  1617 LLFECGIGEEDIDKKASQD---QNFPIQNV--------------------ISQHRALIFCQLKDM 1658

  Fly   921 LDILRDHLSK---DGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANH 982
            ||::.:.|.|   ..|..:.|:|:|..::||.:|.:||: :.....|||:...||:||||.||:.
Yeast  1659 LDMVENDLFKKYMPSVTYMRLDGSIDPRDRQKVVRKFNE-DPSIDCLLLTTKVGGLGLNLTGADT 1722

  Fly   983 LLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVL 1041
            ::.::..|||..:.||.||.:|:||||.|.:|:.:...|:|::|.|||..|:::|..|:
Yeast  1723 VIFVEHDWNPMNDLQAMDRAHRIGQKKVVNVYRIITKGTLEEKIMGLQKFKMNIASTVV 1781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	194/843 (23%)
		DEXHc_TTF2	439..686	CDD:350830	71/262 (27%)
MOT1	NP_015243.1	HEAT repeat	360..385	CDD:293787
		HEAT repeat	406..438	CDD:293787
		HEAT repeat	449..481	CDD:293787
		HEAT repeat	490..519	CDD:293787
		HEAT repeat	543..572	CDD:293787
		DUF3535	611..1063	CDD:463447	62/302 (21%)
		HepA	<1258..1781	CDD:440319	160/648 (25%)