Protein Alignment lds and ISW2

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_014948.1
• Gene: ISW2 / 854480
• SGDID: S000005831
• Length: 1120
• Species: Saccharomyces cerevisiae
• Alignment Length: 910
• Identity: 219/910 - (24%)
• Similarity: 355/910 - (39%)
• Gaps: 305/910 - (33%)

  Fly   204 SNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQK 268
            |..|:|.|:|..|.|                 |||   ..|:....:..|:.||...|..|..:.
Yeast    15 SKSESPSEVLVDTLD-----------------SKS---NGSSDDDNIGQSEELSDKEIYTVEDRP 59

  Fly   269 TSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLFE---------------KVAH 318
            ....|.|:       :|.|..|  |.:..|..:|    ||..|.|:               |..|
Yeast    60 PEYWAQRK-------KKFVLDV--DPKYAKQKDK----SDTYKRFKYLLGVTDLFRHFIGIKAKH 111

  Fly   319 KLPDKGSQ-IMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELS 382
               ||..| ::|::|:...:|:.....:|:         :.|..:.|....        |.:.::
Yeast   112 ---DKNIQKLLKQLDSDANKLSKSHSTVSS---------SSRHHRKTEKEE--------DAELMA 156

  Fly   383 EAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKV-SLMNHQKHA 446
            :...||...|.                   :|:.||           |.|..:|. .|.::|...
Yeast   157 DEEEEIVDTYQ-------------------EDIFVS-----------ESPSFVKSGKLRDYQVQG 191

  Fly   447 LAWM-SWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKS 510
            |.|: |..|.||  .|||||:|||||||..||.:...:..:::
Yeast   192 LNWLISLHENKL--SGILADEMGLGKTLQTISFLGYLRYVKQI---------------------- 232

  Fly   511 VTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRD---- 571
                         .|..|::.|.|.|..|..|.....  ..:.|.|.|| :::|:...:|:
Yeast   233 -------------EGPFLIIVPKSTLDNWRREFLKWT--PNVNVLVLHG-DKDTRADIVRNIILE 281

  Fly   572 --YDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTP 634
              :|:::|:|::|.||..:|..   :.|:.|::||||.::|.:|..|..:.....|.|..:||||
Yeast   282 ARFDVLITSYEMVIREKNALKR---LAWQYIVIDEAHRIKNEQSALSQIIRLFYSKNRLLITGTP 343

  Fly   635 IQNKELDVYALLKFLRCSPFDDLHTWKKWID-NKSAGGQ----NRLNLLMKSLMLRRTKAQLQSD 694
            :||...:::|||.||....|.|...:.:|.: |.|...|    .:|:.::...:|||.||.::
Yeast   344 LQNNLHELWALLNFLLPDIFGDSELFDEWFEQNNSEQDQEIVIQQLHSVLNPFLLRRVKADVE-- 406

  Fly   695 GKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFN---YRSDANKPTY 756
                    |.|      |.|.|.|||..:                   ||..   |:|...|
Yeast   407 --------KSL------LPKIETNVYVGM-------------------TDMQIQWYKSLLEK--- 435

  Fly   757 NQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHS 821
             .|...|||.            .|:|.|:. :|.::::||:.|.||.|.:
Yeast   436 -DIDAVNGAV------------GKREGKTR-LLNIVMQLRKCCNHPYLFE--------------- 471

  Fly   822 SDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLH 886
                                            ..:.|||...||              :.:||
Yeast   472 --------------------------------GAEPGPPYTTDE--------------HLIFN-- 488

  Fly   887 RPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIV 951
              |.|:.::.::||.  ||....:.::.||.:.:||||.|:..........::|:...:.|.:.:
Yeast   489 --SGKMIILDKLLKR--LKEKGSRVLIFSQMSRLLDILEDYCYFRDFEYCRIDGSTSHEERIEAI 549

  Fly   952 NEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKF 1016
            :|:|..|::|.|.||:..|||:|:||:.|:.::|.|..||||.:.||.||.:|:||||.|.:|:|
Yeast   550 DEYNKPNSEKFVFLLTTRAGGLGINLVTADTVILFDSDWNPQADLQAMDRAHRIGQKKQVHVYRF 614

  Fly  1017 MCVDTVEQRI-----------------------KGLQDKKLDLADGVLTGA-----KVSSKLTID 1053
            :..:.:|:::                       ..|.:.|.||.|.:..||     |.:||:|:|
Yeast   615 VTENAIEEKVIERAAQKLRLDQLVIQQGTGKKTASLGNSKDDLLDMIQFGAKNMFEKKASKVTVD 679

  Fly  1054  1053
            Yeast   680  679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	193/808 (24%)
		DEXHc_TTF2	439..686	CDD:350830	72/258 (28%)
ISW2	NP_014948.1	PLN03142	1..1093	CDD:215601	219/910 (24%)