Protein Alignment lds and RAD26

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_012569.1
• Gene: RAD26 / 853492
• SGDID: S000003796
• Length: 1085
• Species: Saccharomyces cerevisiae
• Alignment Length: 1082
• Identity: 242/1082 - (22%)
• Similarity: 399/1082 - (36%)
• Gaps: 365/1082 - (33%)

  Fly    85 EDSEDDSVRPSARNTKRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSD 149
            ||.|.........|...|.||:...|   :..||::..:..|..|    ..|.|..:::.:|.|
Yeast     2 EDKEQQDNAKLENNESLKDLGVNVLS---QSSLEEKIANDVTNFS----NLQSLQQEETRLERS- 58

  Fly   150 EVQEGPTEAPTAEAVVPRY-------------TTQFAGNIQNDLHSTIGAADSE----VLDDSSG 197
                        :..:.||             ||:.  :::.:|...|....|:    ||.|
Yeast    59 ------------KTALQRYVNKKNHLTRKLNNTTRI--SVKQNLRDQIKNLQSDDIERVLKD--- 106

  Fly   198 SDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQ 262
                 :.:.::.|:.|....|....||.:..|  .:||.:      :....:::|.|      |.
Yeast   107 -----IDDIQSRIKELKEQVDQGAENKGSKEG--LQRPGE------TEKEFLIRTGK------IT 152

  Fly   263 AV-LKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQ-VSDAEKLFEKVAHKLPDKGS 325
            |. .|...|.....|...|:::||       ||:.....|:.|: ::|.:.......:::..|.|
Yeast   153 AFGHKAGFSLDTANREYAKNDEQK-------DEDFEMATEQMVENLTDEDDNLSDQDYQMSGKES 210

  Fly   326 Q----------IMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDE 380
            :          |:|.::.||            .|.|               |..|..    |.||
Yeast   211 EDDEEEENDDKILKELEDLR------------FRGQ---------------PGEAKD----DGDE 244

  Fly   381 LSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLED--------LPGPEVLAEDPVGLKV 437
            |.......|.|...:.|     :|::..|...:..|.::.|        :|| |:.:
Yeast   245 LYYQERLKKWVKQRSCG-----SQRSSDLPEWRRPHPNIPDAKLNSQFKIPG-EIYS-------- 295

  Fly   438 SLMNHQKHALAWMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSED 502
            .|.|:||..:.|: :...:...|||:.|:||||||:.:|:.:.|..:...::
Yeast   296 LLFNYQKTCVQWL-YELYQQNCGGIIGDEMGLGKTIQVIAFIAALHHSGLLT------------- 346

  Fly   503 DKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQW---------------------------- 539
                                  |..|:||||::::||
Yeast   347 ----------------------GPVLIVCPATVMKQWCNEFQHWWPPLRTVILHSMGSGMASDQK 389

  Fly   540 ----ESEVESKVSRQKLTVCVHHG--NNRETK-------------GKYLRDYDIVVTTYQIVARE 585
                |:::|:.:...|.:...:..  |:..||             .|.:.|..|::||| :..|.
Yeast   390 FKMDENDLENLIMNSKPSDFSYEDWKNSTRTKKALESSYHLDKLIDKVVTDGHILITTY-VGLRI 453

  Fly   586 HKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLR 650
            |.  ..:..|||:..:|||.|.:||..|:.||....|:...|..|:||||||...::::|..|:.
Yeast   454 HS--DKLLKVKWQYAVLDEGHKIRNPDSEISLTCKKLKTHNRIILSGTPIQNNLTELWSLFDFIF 516

  Fly   651 CSPFDDLHTWKKW--IDNKSAGGQNRLNL--------------LMKSLMLRRTKAQLQSDGKLNS 699
            ......|..:::.  |.....|..|..|:              |:...:|||.||.:..|
Yeast   517 PGKLGTLPVFQQQFVIPINIGGYANATNIQVQTGYKCAVALRDLISPYLLRRVKADVAKD----- 576

  Fly   700 LPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNG 764
            ||           .|:||.::..:..|.|:.:.:|||.           ||     .|||::
Yeast   577 LP-----------QKKEMVLFCKLTKYQRSKYLEFLHS-----------SD-----LNQIQN--- 611

  Fly   765 AYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEI 829
                         |.:..:...||      ||:||.||.|:|
Yeast   612 -------------GKRNVLFGIDI------LRKICNHPDLLD----------------------- 634

  Fly   830 DLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINM 894
                       .||                                 ||.||.:...:.|.|:.:
Yeast   635 -----------RDT---------------------------------KRHNPDYGDPKRSGKMQV 655

  Fly   895 VIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLS-KD----GVATLSLNGTIPVKNRQDIVNEF 954
            |.|:|  .:......||::.:|...:||||.:.:| ||    .:..|.::||..:|.||.:|:.|
Yeast   656 VKQLL--LLWHKQGYKALLFTQSRQMLDILEEFISTKDPDLSHLNYLRMDGTTNIKGRQSLVDRF 718

  Fly   955 NDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCV 1019
            |  |....|.||:...||:|:||.|||.:::.|..|||..:.||::|.:|:|||:.|.||:.|..
Yeast   719 N--NESFDVFLLTTRVGGLGVNLTGANRIIIFDPDWNPSTDMQARERAWRIGQKREVSIYRLMVG 781

  Fly  1020 DTVEQRIKGLQDKKLDLADGVLTGAKVSSKLTIDDLKGLFGM 1061
            .::|::|...|..|..|.:.:||..|......|.:|..||.:
Yeast   782 GSIEEKIYHRQIFKQFLTNRILTDPKQKRFFKIHELHDLFSL 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	191/840 (23%)
		DEXHc_TTF2	439..686	CDD:350830	69/309 (22%)
RAD26	NP_012569.1	HepA	<222..792	CDD:440319	181/778 (23%)
		CSB_WHD	1019..1080	CDD:439329