Protein Alignment lds and INO80

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_011365.1
• Gene: INO80 / 852728
• SGDID: S000003118
• Length: 1489
• Species: Saccharomyces cerevisiae
• Alignment Length: 1373
• Identity: 267/1373 - (19%)
• Similarity: 510/1373 - (37%)
• Gaps: 403/1373 - (29%)

  Fly     4 ENSEYYSDKEEDSVVNNSSLGR--SRKSSRLS--KSSRLSKSSRPSSAGVVIDETQS-------- 56
            ::.:...|.|||...:.:|.||  :.||.|.:  :.||...::..::.|..|.:.|:
Yeast   147 DDEDELEDGEEDMEEDEASTGRHTNGKSMRGNGIQKSRKKDAAAAAAIGKAIKDDQTHADTVVTV 211

  Fly    57 ---EEEESQSSETAESEKSDESDN-------------SQNSQESEDSEDDSVRPSARNTKRKPLG 105
               |.|:..:.|..:::..:|::|             |.|..|.|:.|:|.......:...:...
Yeast   212 NGDENEDGNNGEDEDNDNDNENNNDNDNDNENENDNDSDNDDEEENGEEDEEEEEIEDLDEEDFA 276

  Fly   106 IPSDSEDEEDE-----LEQR-----ALSPSTRMSITGV-----------------RPQ------- 136
            ...:.:|.:||     :|:|     :.|.||::|:..:                 ||:
Yeast   277 AFEEQDDNDDEDFNPDVEKRRKRSSSSSSSTKLSMNSLSLITSKKINKNITINSDRPKIVRELIK 341

  Fly   137 ---------------------DLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQND- 179
                                 |.:..||::              ..:..:.:|..:....:.||
Yeast   342 MCNKNKHQKIKKRRFTNCIVTDYNPIDSKL--------------NIKITLKQYHVKRLKKLINDA 392

  Fly   180 ---------LHSTIGAADSEVLDDSSGSDVLILSNKETPIEILSSTD-DDATTNKENMSG--PPF 232
                     |.:.:|...:::.:|..||:    |:|...:...::.. |||...|.|...  |.:
Yeast   393 KREREREEALKNNVGLDGNDLDNDEDGSE----SHKRRKLNNNTANGADDANKRKFNTRHGLPTY 453

  Fly   233 ERPSKSLSPRS---------------SAGASVVKTSKNLSQ-PTIQAVLKQKTSPAAPRRSRIKS 281
            .....:...|:               .|.....|.|:.:.| .:|::...:|||....|.:  |.
Yeast   454 GMKMNAKEARAIQRHYDNTYTTIWKDMARKDSTKMSRLVQQIQSIRSTNFRKTSSLCAREA--KK 516

  Fly   282 EDQKVVSQVV----------------------YDEEMRKLAEK----RVQVSDAEKLFEKVAHKL 320
            ...|...|:.                      .:.:::|..||    :.:..:.||..::.|.||
Yeast   517 WQSKNFKQIKDFQTRARRGIREMSNFWKKNEREERDLKKKIEKEAMEQAKKEEEEKESKRQAKKL 581

  Fly   321 PDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAV 385
            ....:|.......:.|::..:|  :....|..::..:.:.:..:...|.......:|:|..::..
Yeast   582 NFLLTQTELYSHFIGRKIKTNE--LEGNNVSSNDSESQKNIDISALAPNKNDFHAIDFDNENDEQ 644

  Fly   386 NEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLED-----LPGP----EVLAEDPVGLKVSLMN 441
            ..::.....:..:|. ...||...:...:.|...|:     ...|    |:..|.|..|..:|..
Yeast   645 LRLRAAENASNALAE-TRAKAKQFDDHANAHEEEEEEDELNFQNPTSLGEITIEQPKILACTLKE 708

  Fly   442 HQKHALAWMSWRERKLPRG--GILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDK 504
            :|...|.|::   ....:|  |||||:||||||:..| ||||     .::|..:.
Yeast   709 YQLKGLNWLA---NLYDQGINGILADEMGLGKTVQSI-SVLA-----HLAENHNI---------- 754

  Fly   505 NKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKY- 568
                     |          |..|||.|||.|..|.:|:...:.:.|:.....:.|:|:...|:
Yeast   755 ---------W----------GPFLVVTPASTLHNWVNEISKFLPQFKILPYWGNANDRKVLRKFW 800

  Fly   569 ----LR-----DYDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRG 624
                ||     .:.::||:||:|..:...|..   :||:.:|||||..:::.:|.....:.....
Yeast   801 DRKNLRYNKNAPFHVMVTSYQMVVTDANYLQK---MKWQYMILDEAQAIKSSQSSRWKNLLSFHC 862

  Fly   625 KYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWI--DNKSAGGQN---------RLNLL 678
            :.|..||||||||...:::|||.|:..|.||....:.:|.  |.:|....|         ||:::
Yeast   863 RNRLLLTGTPIQNSMQELWALLHFIMPSLFDSHDEFNEWFSKDIESHAEANTKLNQQQLRRLHMI 927

  Fly   679 MKSLMLRRTKAQLQSD-------GKLNSLPNKELRLIEI-------------------------S 711
            :|..||||.|..:||:       ..|..|..::.:|.::                         |
Yeast   928 LKPFMLRRVKKNVQSELGDKIEIDVLCDLTQRQAKLYQVLKSQISTNYDAIENAATNDSTSNSAS 992

  Fly   712 LDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNY-----------------------RSDANK 753
            ....:.|:...||.:.:......|.:||:.::.|::                       .|:.|.
Yeast   993 NSGSDQNLINAVMQFRKVCNHPDLFERADVDSPFSFTTFGKTTSMLTASVANNNSSVISNSNMNL 1057

  Fly   754 PTYNQIKDPNGAY------------YKM------------HEKFARMAGSKKEVK--------SH 786
            .:.:.....||.:            |.:            :.....:|...|.||        ::
Yeast  1058 SSMSSNNISNGKFTDLIYSSRNPIKYSLPRLIYEDLILPNYNNDVDIANKLKNVKFNIFNPSTNY 1122

  Fly   787 DILVLLLRLRQICCHPGLID-------AMLDGEESQTMGDHSSDS---------------DTPEI 829
            ::.:.|.:|..   .|.|.:       .:|.....:|.|..::||               :.|..
Yeast  1123 ELCLFLSKLTG---EPSLNEFFRVSTTPLLKRVIERTNGPKNTDSLSFKTITQELLEVTRNAPSE 1184

  Fly   830 DLLAQL---NKLAITDTSTDGQQSVANAGDDGPPLLPD----------------EARIAKASKNL 875
            .::|.|   .|.|......:..|...:.....||:..:                :..|::|..::
Yeast  1185 GVMASLLNVEKHAYEREYLNCIQRGYHPNVSAPPVTIEVLGSSHVTNSINNELFDPLISQALSDI 1249

  Fly   876 ---------LKRSNPV------------------FNLHRP--------SSKINMVIQILKTSILK 905
                     :|:..||                  .|:..|        |:|:..:.::|..  ||
Yeast  1250 PAITQYNMHVKKGIPVEDFPKTGLFPEPLNKNFSSNISMPSMDRFITESAKLRKLDELLVK--LK 1312

  Fly   906 SSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTA 970
            |...:.::..|.|.::|::.::|:......:.|:|:..:::|:|:|::: ..|.:..|.|||..|
Yeast  1313 SEGHRVLIYFQMTKMMDLMEEYLTYRQYNHIRLDGSSKLEDRRDLVHDW-QTNPEIFVFLLSTRA 1376

  Fly   971 GGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLD 1035
            ||:|:||..|:.::..|..|||.:::||.||.:|:||.:.|.:|:.:...|:|:|::....:|..
Yeast  1377 GGLGINLTAADTVIFYDSDWNPTIDSQAMDRAHRLGQTRQVTVYRLLVRGTIEERMRDRAKQKEQ 1441

  Fly  1036 LADGVLTG 1043
            :...|:.|
Yeast  1442 VQQVVMEG 1449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	197/974 (20%)
		DEXHc_TTF2	439..686	CDD:350830	78/269 (29%)
INO80	NP_011365.1	DBINO	469..602	CDD:464024	22/134 (16%)
		PLN03142	537..>1026	CDD:215601	118/532 (22%)
		DEXQc_INO80	706..935	CDD:350760	78/269 (29%)
		SF2_C_SNF	1295..1423	CDD:350180	40/130 (31%)