Protein Alignment lds and ISW1

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_009804.1
• Gene: ISW1 / 852547
• SGDID: S000000449
• Length: 1129
• Species: Saccharomyces cerevisiae
• Alignment Length: 786
• Identity: 182/786 - (23%)
• Similarity: 316/786 - (40%)
• Gaps: 235/786 - (29%)

  Fly   292 YDEEMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVP 356
            :|.|..|   ||..:.||.      ..|...:|:  .||.:.|.....:.:.:|.:
Yeast    81 HDPESNK---KRYLLKDAN------GKKFDLEGT--TKRFEHLLSLSGLFKHFIES--------- 125

  Fly   357 AVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLED 421
                 |...:|.....:|.|   |.::|..:.|..:...:...|.:.:.|   |.||:     ||
Yeast   126 -----KAAKDPKFRQVLDVL---EENKANGKGKGKHQDVRRRKTEHEEDA---ELLKE-----ED 174

  Fly   422 LPGPEVL----AEDPVGLKVSLMNHQKHALAWM-SWRERKLPRGGILADDMGLGKTLTMISSVLA 481
            ....|.:    .|.|..:...|..:|...:.|: |..:.|:  .|||||:|||||||..||.:..
Yeast   175 SDDDESIEFQFRESPAYVNGQLRPYQIQGVNWLVSLHKNKI--AGILADEMGLGKTLQTISFLGY 237

  Fly   482 CKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQW------- 539
            .:..:::.                                   |..||:.|.|.|..|
Yeast   238 LRYIEKIP-----------------------------------GPFLVIAPKSTLNNWLREINRW 267

  Fly   540 -----------ESEVESKVSRQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVAREHKSLSAVF 593
                       :.|..:::.::||..|               |:|:|:.:|:|:.||...|..
Yeast   268 TPDVNAFILQGDKEERAELIQKKLLGC---------------DFDVVIASYEIIIREKSPLKK-- 315

  Fly   594 GVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLH 658
             :.|..||:||||.::|.:|..|..:.:...:.|..:||||:||...:::|||.||....|.|..
Yeast   316 -INWEYIIIDEAHRIKNEESMLSQVLREFTSRNRLLITGTPLQNNLHELWALLNFLLPDIFSDAQ 379

  Fly   659 TWKKWIDNKSAGGQ-----NRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMN 718
            .:..|..::|....     .:|:.:::..:|||.|    ||.:.:.||.|||            |
Yeast   380 DFDDWFSSESTEEDQDKIVKQLHTVLQPFLLRRIK----SDVETSLLPKKEL------------N 428

  Fly   719 VYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEV 783
            :|..:.:..:..:.:.|    |::.|             .:...||:               ||.
Yeast   429 LYVGMSSMQKKWYKKIL----EKDLD-------------AVNGSNGS---------------KES 461

  Fly   784 KSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQ 848
            |:. :|.::::||:.|.||.|.|
Yeast   462 KTR-LLNIMMQLRKCCNHPYLFD------------------------------------------ 483

  Fly   849 QSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIV 913
                 ..:.|||...||              :.|:|    ::|:.::.::||.  ||....:.::
Yeast   484 -----GAEPGPPYTTDE--------------HLVYN----AAKLQVLDKLLKK--LKEEGSRVLI 523

  Fly   914 VSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLI 978
            .||.:.:||||.|:..........::|:...::|...::::|..:::|.|.||:..|||:|:||.
Yeast   524 FSQMSRLLDILEDYCYFRNYEYCRIDGSTAHEDRIQAIDDYNAPDSKKFVFLLTTRAGGLGINLT 588

  Fly   979 GANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTG 1043
            .|:.::|.|..||||.:.||.||.:|:||||.|.:::.:..::||::|.....:||.|...|:..
Yeast   589 SADVVVLYDSDWNPQADLQAMDRAHRIGQKKQVKVFRLVTDNSVEEKILERATQKLRLDQLVIQQ 653

  Fly  1044 AKVSSK 1049
            .:.|.|
Yeast   654 NRTSLK 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	179/776 (23%)
		DEXHc_TTF2	439..686	CDD:350830	66/270 (24%)
ISW1	NP_009804.1	PLN03142	108..1057	CDD:215601	172/748 (23%)