Protein Alignment lds and RAD16

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_009672.1
• Gene: RAD16 / 852411
• SGDID: S000000318
• Length: 790
• Species: Saccharomyces cerevisiae
• Alignment Length: 1019
• Identity: 233/1019 - (22%)
• Similarity: 399/1019 - (39%)
• Gaps: 327/1019 - (32%)

  Fly   126 TRMSITGVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSE 190
            ||.:...|...:|||||:.::.|.                   |.|..||.:|    ...:.|.|
Yeast    12 TRSTKKSVNYNELSDDDTAVKNSK-------------------TLQLKGNSEN----VNDSQDEE 53

  Fly   191 VLDDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKN 255
            ..||::               ::.|.|||......:::|...||.:               |.:|
Yeast    54 YRDDAT---------------LVKSPDDDDKDFIIDLTGSDKERTA---------------TDEN 88

  Fly   256 LSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLFEKVAHKL 320
                                ...||:::.:::          ::.|:| .|||.::...|
Yeast    89 --------------------THAIKNDNDEII----------EIKEER-DVSDDDEPLTK----- 117

  Fly   321 PDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSI-----DTLDWDE 380
                    ||..|.|::                       .|.|....::|.:     :||   .
Yeast   118 --------KRKTTARKK-----------------------KKKTSTKKKSPKVTPYERNTL---R 148

  Fly   381 LSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKH 445
            |.|...|::.|:|..:....:..|:                       ::.|.|:.:.|:..|..
Yeast   149 LYEHHPELRNVFTDLKNAPPYVPQR-----------------------SKQPDGMTIKLLPFQLE 190

  Fly   446 ALAWMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKS 510
            .|.|:..:|..:..||:|||:||:|||:..|:.::
Yeast   191 GLHWLISQEESIYAGGVLADEMGMGKTIQTIALLM------------------------------ 225

  Fly   511 VTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRDYDIV 575
                     .|..:..:|||.|...|.||::|:|.....| |.:.::||.:|.|..|.|:.||:|
Yeast   226 ---------NDLTKSPSLVVAPTVALMQWKNEIEQHTKGQ-LKIYIYHGASRTTDIKDLQGYDVV 280

  Fly   576 VTTYQI---VAREH-----------KSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKY 626
            :|||.:   |.|:.           |..|.:..:.:.|:||||||.:::.:|.::.||.:|:.:.
Yeast   281 LTTYAVLESVFRKQNYGFRRKNGLFKQPSVLHNIDFYRVILDEAHNIKDRQSNTARAVNNLKTQK 345

  Fly   627 RWALTGTPIQNKELDVYALLKFLRCSPF------------------DDLH--------------- 658
            ||.|:|||:||:..::|:|::||..:||                  |.:|
Yeast   346 RWCLSGTPLQNRIGEMYSLIRFLNINPFTKYFCTKCDCASKDWKFTDRMHCDHCSHVIMQHTNFF 410

  Fly   659 -------TWKKWIDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEE 716
                   ..|..::.......|.:..|:|::||||||.:...|   ..||.:.:.:.....::||
Yeast   411 NHFMLKNIQKFGVEGPGLESFNNIQTLLKNIMLRRTKVERADD---LGLPPRIVTVRRDFFNEEE 472

  Fly   717 MNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKK 781
            .::|:::.|.|:..:..|:.:.....   ||   ||
Yeast   473 KDLYRSLYTDSKRKYNSFVEEGVVLN---NY---AN----------------------------- 502

  Fly   782 EVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMG----DHSSDSDTPEID------------ 830
                  |..|:.|:||:..||.|:...|:......:|    ...:|.....|:
Yeast   503 ------IFTLITRMRQLADHPDLVLKRLNNFPGDDIGVVICQLCNDEAEEPIESKCHHKFCRLCI 561

  Fly   831 ------LLAQLNKLAITDTSTDGQQSVANAG---DDGPPLLPDEARIAKASKNLLKRSNPVFNLH 886
                  .:...|||..         .|.:.|   |...|.|..:....| .::::.|.| :....
Yeast   562 KEYVESFMENNNKLTC---------PVCHIGLSIDLSQPALEVDLDSFK-KQSIVSRLN-MSGKW 615

  Fly   887 RPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIV 951
            :.|:||..:::.|..........|:||.||:||:||::...|.:.|..|:.|.|::....|.:.:
Yeast   616 QSSTKIEALVEELYKLRSNKRTIKSIVFSQFTSMLDLVEWRLKRAGFQTVKLQGSMSPTQRDETI 680

  Fly   952 NEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKF 1016
            ..|.: |.|..|.|:||.||||.|||..|:.:.:||..|||.:|.|:.||::|:||.:.|.|.:|
Yeast   681 KYFMN-NIQCEVFLVSLKAGGVALNLCEASQVFILDPWWNPSVEWQSGDRVHRIGQYRPVKITRF 744

  Fly  1017 MCVDTVEQRIKGLQDKKLDLADGVLTGAKVS-SKLTIDDLKGLF 1059
            ...|::|.||..||:||.::....:...:.: |:||..||:.||
Yeast   745 CIEDSIEARIIELQEKKANMIHATINQDEAAISRLTPADLQFLF 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	197/837 (24%)
		DEXHc_TTF2	439..686	CDD:350830	77/300 (26%)
RAD16	NP_009672.1	HepA	<172..769	CDD:440319	177/715 (25%)
		RING-HC_RAD16-like	536..584	CDD:438229	6/56 (11%)