Protein Alignment lds and RDH54

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_009629.6
• Gene: RDH54 / 852365
• SGDID: S000000277
• Length: 958
• Species: Saccharomyces cerevisiae
• Alignment Length: 1040
• Identity: 232/1040 - (22%)
• Similarity: 390/1040 - (37%)
• Gaps: 306/1040 - (29%)

  Fly   128 MSITGVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVL 192
            |::..|:|:.......|::.| .|.:...::.|.:..:|:|.     |........:|
Yeast     1 MAVISVKPRRREKILQEVKNS-SVYQTVFDSGTTQMQIPKYE-----NKPFKPPRRVG------- 52

  Fly   193 DDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAG--ASVVKTSKN 255
                       |||.|.::..::....|..:|..:        :.:|....|||  .::.|...|
Yeast    53 -----------SNKYTQLKPTATAVTTAPISKAKV--------TVNLKRSISAGPTLNLAKKPNN 98

  Fly   256 LS-------------QPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVS 307
            ||             :||.:   |.||. :....:.:|:...|:   ..|:|..:.|....:. |
Yeast    99 LSSNENTRYFTIMYRKPTTK---KHKTW-SGDGYATLKASSDKL---CFYNEAGKFLGSSMLP-S 155

  Fly   308 DAEKLFEKVAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPS 372
            |::.|||    .|...||..::    |..||..:.:..||......|:.     .|  :||...:
Yeast   156 DSDSLFE----TLFKAGSNEVQ----LDYELKENAEIRSAKEALSQNMG-----NP--SPPTTST 205

  Fly   373 IDTLDWDE---------LSE--AVNEIKPVYTGAQGM--------ATFNNQKALTLESLKDLHVS 418
            .:|:...:         ||:  ::|.:|...:..:..        .|..|.||.....:.|::
Yeast   206 TETVPSTKNDGGKYQMPLSQLFSLNTVKRFKSVTKQTNEHMTTVPKTSQNSKAKKYYPVFDVN-- 268

  Fly   419 LEDLPGPEVL-----AE-----DPVGLKVSLMNHQKHALAWMSWRERKLPR-------------- 459
              .:..|.|:     ||     ||: |...|..||:..:.:|......|.|
Yeast   269 --KIDNPIVMNKNAAAEVDVIVDPL-LGKFLRPHQREGVKFMYDCLMGLARPTIENPDIDCTTKS 330

  Fly   460 ----------GGILADDMGLGKTL---TMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSV 511
                      |.:|||||||||||   |:|.:::.    |.....|...|.|..         .:
Yeast   331 LVLENDSDISGCLLADDMGLGKTLMSITLIWTLIR----QTPFASKVSCSQSGI---------PL 382

  Fly   512 TGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKY-LRDYDIV 575
            ||...|         .|||||.:|:..|:.|....::..::.|......|.....|. :|::..|
Yeast   383 TGLCKK---------ILVVCPVTLIGNWKREFGKWLNLSRIGVLTLSSRNSPDMDKMAVRNFLKV 438

  Fly   576 VTTYQIVAREHKSLSAVFGVKWRR------IILDEAHVVRNHKSQ--SSLAVCDLRGKYRWALTG 632
            ..|||::...::.|.:|.....:.      ::.||.|.::|..|:  ::|...|:|.|.  .|||
Yeast   439 QRTYQVLIIGYEKLLSVSEELEKNKHLIDMLVCDEGHRLKNGASKILNTLKSLDIRRKL--LLTG 501

  Fly   633 TPIQNKELDVYALLKFLRCSPFDDLHTWKKWI---DNKSAGGQNRLN---------------LLM 679
            |||||...:.:.::.|:.........::|:..   ..::....||.|               .:.
Yeast   502 TPIQNDLNEFFTIIDFINPGILGSFASFKRRFIIPITRARDTANRYNEELLEKGEERSKEMIEIT 566

  Fly   680 KSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETD 744
            |..:||||.|.|:     ..||.|...::......:::..::.::..:|..|.|.
Yeast   567 KRFILRRTNAILE-----KYLPPKTDIILFCKPYSQQILAFKDILQGARLDFGQL---------- 616

  Fly   745 FNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAML 809
                                       .|:...|            |:..|:::|..|||:
Yeast   617 ---------------------------TFSSSLG------------LITLLKKVCNSPGLV---- 638

  Fly   810 DGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDT-STDGQQSVANAGDDGPPLLPDEARIAKASK 873
                       .||          ...|..|.|| |.|......|:|
Yeast   639 -----------GSD----------PYYKSHIKDTQSQDSYSRSLNSG------------------ 664

  Fly   874 NLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSL 938
                             |:.:::.:|: .|.|.:.:|.:|||.:|..|||:.:.::..|::...|
Yeast   665 -----------------KLKVLMTLLE-GIRKGTKEKVVVVSNYTQTLDIIENLMNMAGMSHCRL 711

  Fly   939 NGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIY 1003
            :|:||.|.|..||..|| ||......|||..:|||||||:||:.|:|.|..|||.::.||..||:
Yeast   712 DGSIPAKQRDSIVTSFN-RNPAIFGFLLSAKSGGVGLNLVGASRLILFDNDWNPSVDLQAMSRIH 775

  Fly  1004 RVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSSK-------LTIDDLKGLFGM 1061
            |.||||...||:.:....::::|...|..|..|:...|..:::.:|       ...:|||.||.:
Yeast   776 RDGQKKPCFIYRLVTTGCIDEKILQRQLMKNSLSQKFLGDSEMRNKESSNDDLFNKEDLKDLFSV 840

  Fly  1062  1061
            Yeast   841  840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	193/837 (23%)
		DEXHc_TTF2	439..686	CDD:350830	69/300 (23%)
RDH54	NP_009629.6	DUF2439	108..>158	CDD:463065	12/57 (21%)
		DEXHc_RAD54	296..573	CDD:350762	69/300 (23%)
		SF2_C_SNF	663..789	CDD:350180	55/162 (34%)