Protein Alignment lds and FUN30

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_009383.1
• Gene: FUN30 / 851214
• SGDID: S000000017
• Length: 1131
• Species: Saccharomyces cerevisiae
• Alignment Length: 1124
• Identity: 247/1124 - (21%)
• Similarity: 429/1124 - (38%)
• Gaps: 287/1124 - (25%)

  Fly     9 YSDKEEDSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSETAESEKSD 73
            |:.|......:...:|:|.:||.....|...|.......|...::...|||||..::..::...|
Yeast   205 YNKKRRLVRADQHPIGKSYESSATQLGSAREKLLANRKYGRHANDNDEEEEESMMTDDDDASGDD 269

  Fly    74 ESDNSQNSQESEDSEDDSVRPSARNTKRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDL 138
            .::::     .:.:.|:.|.....::....|   ||..|......|...|.....|:......:.
Yeast   270 YTEST-----PQINLDEQVLQFINDSDIVDL---SDLSDTTMHKAQLIASHRPYSSLNAFVNTNF 326

  Fly   139 SDDDSEIEYSDE-VQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVLDDSSGSDVLI 202
            :|.|:|...|:: .:.....|..:|.::.:.|....|         ..|.:|.:...||..|::.
Yeast   327 NDKDTEENASNKRKRRAAASANESERLLDKITQSIRG---------YNAIESVIKKCSSYGDLVT 382

  Fly   203 LSNKETPIEI-----------LSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNL 256
            ...|:..:::           |...|||...:..|        .:.:.:..::|||......|..
Yeast   383 SQMKKWGVQVEGDNSELDLMNLGEDDDDDNDDGNN--------DNNNSNNNNTAGADATSKEKED 439

  Fly   257 SQPTIQAVLKQKTSPA-APRRSRIKSEDQKVVS----QVVYDEEMRKLAEKRVQVSDAEKLFEKV 316
            ::..::...:....|. ||..:.::.|.:::.:    :||.||:           .|.:  .|.:
Yeast   440 TKAVVEGFDETSAEPTPAPAPAPVERETKRIRNTTKPKVVEDED-----------DDVD--LEAI 491

  Fly   317 AHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDEL 381
            ..:||    |.....|....|   ||.:                      ......::..|.|:.
Yeast   492 DDELP----QSEHEDDDYEEE---DEDY----------------------NDEEEDVEYDDGDDD 527

  Fly   382 SEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPG-PEVLAEDPVGLKVSLMNHQKH 445
            .:..:|.         :||..|...::..|.......::...| |.:|:.:     :||.::|:.
Yeast   528 DDDDDEF---------VATRKNTHVISTTSRNGRKPIVKFFKGKPRLLSPE-----ISLKDYQQT 578

  Fly   446 ALAWMS-WRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRK 509
            .:.|:: ..:.|:  ..|||||||||||..:||.....|...|
Yeast   579 GINWLNLLYQNKM--SCILADDMGLGKTCQVISFFAYLKQINE---------------------- 619

  Fly   510 SVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRD--- 571
                          .|..|||.|:|.|..|..|.:......|:.  .::|:.:|.  :.|||
Yeast   620 --------------PGPHLVVVPSSTLENWLREFQKFAPALKIE--PYYGSLQER--EELRDILE 666

  Fly   572 -----YDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALT 631
                 ||::||||.:.|.....:|.:....:..::.||.|:::|..|:....:..:|..:|..||
Yeast   667 RNAGKYDVIVTTYNLAAGNKYDVSFLKNRNFNVVVYDEGHMLKNSTSERFAKLMKIRANFRLLLT 731

  Fly   632 GTPIQNKELDVYALLKFL-------RCSPFDDL--HTWKKWIDNKSAG------GQNRLNLLMKS 681
            |||:||...::.:||:|:       :...||.:  ...|...|||:..      ...|...:||.
Yeast   732 GTPLQNNLKELMSLLEFIMPNLFISKKESFDAIFKQRAKTTDDNKNHNPLLAQEAITRAKTMMKP 796

  Fly   682 LMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVY----QTVMTYSRTLFAQFLHQRAERE 742
            .:|||.|.|:     |..||.|...:....|:..:..:|    |.|:.:.|.:
Yeast   797 FILRRRKDQV-----LKHLPPKHTHIQYCELNAIQKKIYDKEIQIVLEHKRMI------------ 844

  Fly   743 TDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLI-- 805
                  .|...|     ||               |..|.:::|.....|::.||:...||.|.
Yeast   845 ------KDGELP-----KD---------------AKEKSKLQSSSSKNLIMALRKASLHPLLFRN 883

  Fly   806 -----------DAMLD-------GEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVA 852
                       ||:||       |.:.....|.|..:|       .:|:||.....:|
Yeast   884 IYNDKIITKMSDAILDEPAYAENGNKEYIKEDMSYMTD-------FELHKLCCNFPNT------- 934

  Fly   853 NAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHR----PSSKINMVIQILKTSILKSSDDKAIV 913
                              .||         :.||.    .|.||:.:.::||| |:....:|.::
Yeast   935 ------------------LSK---------YQLHNDEWMQSGKIDALKKLLKT-IIVDKQEKVLI 971

  Fly   914 VSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLI 978
            .|.:|.|||||...||......|.|:|:..|.:||.::::|.: :....:.:||..|||.|:||:
Yeast   972 FSLFTQVLDILEMVLSTLDYKFLRLDGSTQVNDRQLLIDKFYE-DKDIPIFILSTKAGGFGINLV 1035

  Fly   979 GANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTG 1043
            .||::::.|..:||..:.||.||.:||||.|.|.|...:..|::|::|..|...||.| |..::.
Yeast  1036 CANNVIIFDQSFNPHDDRQAADRAHRVGQTKEVNITTLITKDSIEEKIHQLAKNKLAL-DSYISE 1099

  Fly  1044 AKVS-----SKLT--IDDL 1055
            .|.|     ||::  ::|:
Yeast  1100 DKKSQDVLESKVSDMLEDI 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	191/810 (24%)
		DEXHc_TTF2	439..686	CDD:350830	69/270 (26%)
FUN30	NP_009383.1	HepA	<571..1093	CDD:440319	166/649 (26%)