Protein Alignment lds and IRC20

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_013348.1
• Gene: IRC20 / 850949
• SGDID: S000004237
• Length: 1556
• Species: Saccharomyces cerevisiae
• Alignment Length: 964
• Identity: 194/964 - (20%)
• Similarity: 358/964 - (37%)
• Gaps: 305/964 - (31%)

  Fly   210 IEILSSTDDDATT---NKENMS----GPPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQ 267
            ||||...:|:..|   :.:::|    |...|..||            :...|.|  |.|..:...
Yeast    86 IEILPCENDNEATLVVSSDSVSLFQIGFKMENNSK------------IAVDKQL--PLILDICAH 136

  Fly   268 KTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLFEKVAHKL------------ 320
            |....|.|.   :.|::|.:.:    :..||..:|...|:|.|||.:...|:|
Yeast   137 KNQERALRN---QLENRKSLER----KPSRKRRKKNSNVNDPEKLLKSRIHELSLSYKDFECSPV 194

  Fly   321 -----------------------------PDKGSQIMKRIDTLRRELAMD--------------E 342
                                         ..:.:||:....:.|.|...:              :
Yeast   195 VFRYNDSSLTWVLSFNLKLKFLNNKFNRFSVEANQILDLTFSNRDENEFERYHKHSHIHSNFIQK 259

  Fly   343 QWISALRVQQSNVPAVRVVKPTLNPPRAPSI---------DTLDW--------DELSEAVNEIKP 390
            |:||  ::.:.:...:..:||.| |...|.:         ::::|        :.||:....|..
Yeast   260 QFIS--QILEYSKDRLSKIKPFL-PQSIPDLKVNLLPFQRESVEWMLIKEGHGNSLSDTPTVIDE 321

  Fly   391 VYTGAQGMATFNNQ-KALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWMSWRE 454
            |     |:..|.|: .|...|    |.....|..||.:|.....|.   ::..:..|..:..:|:
Yeast   322 V-----GLIDFMNEYYAYGYE----LIARSPDEVGPSLLWNKLTGY---ILTTEDAAHLYNQYRK 374

  Fly   455 RKLP------RGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTG 513
            .:|.      ..|:||::||||||:.::|.:|       ::..|.:.|::...||:|   :::|.
Yeast   375 ERLSGDYPVCAKGVLAEEMGLGKTIEILSLIL-------LNRRKLKDSEATFIDDEN---RTITK 429

  Fly   514 WKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKG--------KYLR 570
            .|:          ||::||.::|:||..|:|  :....|....:.|.|...|.        :.|.
Yeast   430 TKT----------TLIICPNAILKQWLEEIE--LHANSLKWYTYRGYNEIMKDCKTVDEAVQQLC 482

  Fly   571 DYDIVVTTYQIVARE------HKSL-------------SAVFGVKWRRIILDEAHVVRNHKSQSS 616
            .|||:||:|.|:|.|      ::|:             |.:..:::.||||||..::|:..:.|:
Yeast   483 QYDIIVTSYNIIATEVHHAEFNRSIRSRRLKSPKYDYSSPLALMQFYRIILDEVQMLRSSSTYSA 547

  Fly   617 LAVCDLRGKYRWALTGTPIQNKELDVY---ALLKFLRCSPFDDLHTWKKWIDNKSAGGQNRLNLL 678
            .....|...:.|.::||||||    :|   .::.:|:..||.|              ..:.:..|
Yeast   548 KCTSLLHRIHTWGVSGTPIQN----IYNFRMIMSYLKLHPFCD--------------EVDFIRTL 594

  Fly   679 MKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNV---YQTVMTYSRTLFAQFLHQRAE 740
            .:.:.||.......|:..:     .:|:.:..|: |:.||:   |...:.:|:...|..:|  ..
Yeast   595 QEEIKLRNEAKDYTSNDFV-----CQLKGVRFSI-KDCMNIFYRYDLCIRHSKANVASQIH--IP 651

  Fly   741 RETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKE------VKSHDILVLLLRLRQIC 799
            |:.:|....:     :..|:..|  |..:...|..::|...:      |.:..:...|.|||.||
Yeast   652 RQHNFIIPLE-----FAPIEWDN--YLNLWNNFLELSGYNSDGSGSPRVSNAFLNEWLSRLRYIC 709

  Fly   800 CHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLN----------------------KLAITD 842
            || .|...:|...:.:..|..|..|:..:|.:..:::                      :|.|::
Yeast   710 CH-ALFPEILSTRQKRLHGHLSRISNIDDILISMRMDAFDSLIGYYRERFHLSIKQAQYELEISN 773

  Fly   843 TSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSS 907
            |.....:|.....||                 |:......||:..|..|          |:..|.
Yeast   774 TPAKALESFIKIRDD-----------------LMIHIRQKFNVEDPFDK----------SLNLSE 811

  Fly   908 DDKAIVVSQWTSVLDILRDHL---------SKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRV 963
            |:.               :|:         |....:...:||   .||..:..|:....|:.|:.
Yeast   812 DED---------------EHMDERFGEKETSSGDESDREING---AKNHDNHNNDGMLSNHLKKK 858

  Fly   964 LLLSLTAGGVGLNLIGANHLLLLDLHWN---PQLEAQAQDRIYRVGQKKNVIIY 1014
            .|.::      :||:...:..|..:::|   .:|| :|.|:..:  :|...::|
Yeast   859 GLRAM------MNLLHDCYFFLGSVYYNLGTRKLE-EADDKHRK--EKTEEVVY 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	174/880 (20%)
		DEXHc_TTF2	439..686	CDD:350830	69/282 (24%)
IRC20	NP_013348.1	DEXQc_SHPRH	383..602	CDD:350828	66/258 (26%)
		RAD18	1234..>1327	CDD:227719
		RING-HC_IRC20-like	1234..1277	CDD:438497
		SF2_C_SNF	1356..1485	CDD:350180