Protein Alignment lds and SMARCA5

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_003592.3
• Gene: SMARCA5 / 8467
• HGNCID: 11101
• Length: 1052
• Species: Homo sapiens
• Alignment Length: 883
• Identity: 208/883 - (23%)
• Similarity: 338/883 - (38%)
• Gaps: 271/883 - (30%)

  Fly   230 PPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDE 294
            ||...|||..:..:|.|::    |.|...|  :.|..|..:.||              |....|.
Human    12 PPESAPSKPAASIASGGSN----SSNKGGP--EGVAAQAVASAA--------------SAGPADA 56

  Fly   295 EMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVR 359
            ||             |::|:..:   |.|..:|.:...|...::..|........::|:.:.|..
Human    57 EM-------------EEIFDDAS---PGKQKEIQEPDPTYEEKMQTDRANRFEYLLKQTELFAHF 105

  Fly   360 VVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDL-HVSLEDLP 423
            :.......|.:|.              ::||      |.......:...|.|:.|. |...|...
Human   106 IQPAAQKTPTSPL--------------KMKP------GRPRIKKDEKQNLLSVGDYRHRRTEQEE 150

  Fly   424 GPEVLAEDPVGLKV--------------SLMNHQKHALAWM-SWRERKLPRGGILADDMGLGKTL 473
            ..|:|.|......|              .|.::|...|.|: |..|..:  .|||||:|||||||
Human   151 DEELLTESSKATNVCTRFEDSPSYVKWGKLRDYQVRGLNWLISLYENGI--NGILADEMGLGKTL 213

  Fly   474 TMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQ 538
            ..||.:...|:.:.:.                                   |..:|:.|.|.|..
Human   214 QTISLLGYMKHYRNIP-----------------------------------GPHMVLVPKSTLHN 243

  Fly   539 WESEVESKVSRQKLTVCVHHGNNRETKGKYLRD------YDIVVTTYQIVAREHKSLSAVFGVKW 597
            |.||.:..|...: :||:.  .::|.:..::||      :|:.||:|:::.:| ||:...|  .|
Human   244 WMSEFKRWVPTLR-SVCLI--GDKEQRAAFVRDVLLPGEWDVCVTSYEMLIKE-KSVFKKF--NW 302

  Fly   598 RRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKK 662
            |.:::||||.::|.||:.|..|.:.:...|..|||||:||...::::||.||....|:....:..
Human   303 RYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFNSADDFDS 367

  Fly   663 WID-NKSAGGQ---NRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTV 723
            |.| |...|.|   .||:::::..:|||.||.::     .|||.|:...|.:.|.|.:...|..:
Human   368 WFDTNNCLGDQKLVERLHMVLRPFLLRRIKADVE-----KSLPPKKEVKIYVGLSKMQREWYTRI 427

  Fly   724 MTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDI 788
            :                                  :||.:         ....||...:::   :
Human   428 L----------------------------------MKDID---------ILNSAGKMDKMR---L 446

  Fly   789 LVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVAN 853
            |.:|::||:.|.||.|.|
Human   447 LNILMQLRKCCNHPYLFD----------------------------------------------- 464

  Fly   854 AGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWT 918
            ..:.|||...|                    :|..::...||:.......||....:.::.||.|
Human   465 GAEPGPPYTTD--------------------MHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMT 509

  Fly   919 SVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHL 983
            .|||||.|:..........|:|..|...|||.:|.:|:.|:.|.|.:||..|||:|:||..|:.:
Human   510 RVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGINLATADVV 574

  Fly   984 LLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKV-- 1046
            :|.|..||||::.||.||.:|:||.|.|.:::|:..:|||:||....:.||.|...|:...::
Human   575 ILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVD 639

  Fly  1047 --------------------------SSKLTIDDLKGL 1058
                                      .|::|.:|:.|:
Human   640 QNLNKIGKDEMLQMIRHGATHVFASKESEITDEDIDGI 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	189/779 (24%)
		DEXHc_TTF2	439..686	CDD:350830	75/257 (29%)
SMARCA5	NP_003592.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83		24/106 (23%)
		PLN03142	69..1012	CDD:215601	187/790 (24%)
		DEAH box	308..311		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1052