Protein Alignment lds and TTF2

DIOPT Version :9

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_016858039.1
• Gene: TTF2 / 8458
• HGNCID: 12398
• Length: 1190
• Species: Homo sapiens
• Alignment Length: 1187
• Identity: 392/1187 - (33%)
• Similarity: 576/1187 - (48%)
• Gaps: 264/1187 - (22%)

  Fly     1 MSSENSEYYSDKEE----DSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEE--E 59
            :..|..|..:||::    |.:.:..   :.:|...:.|.  ||....|.....|:.|.:.||  |
Human   142 IKGEGEEKKADKKQREKGDQLFDQK---KEQKPEMMEKD--LSSGLVPKKKQSVVQEKKQEEGAE 201

  Fly    60 ESQSSETAESEKSDESD-NSQNSQESEDSEDDSVRPSARNTKRKPLGIPSDSEDEEDELEQRALS 123
            ....:||..:.|.|.|: .||..|.:|     ..|||| :::.|..|...|.:.|.:.|.::
Human   202 IQCEAETGGTHKRDFSEIKSQQCQGNE-----LTRPSA-SSQEKSSGKSQDVQRESEPLREK--- 257

  Fly   124 PSTRMSITGVRPQDLSDDDS----------EIEYSD------EVQEGPTEAPTAEAVVPRYTTQF 172
                  :|.:.||::...:|          ..||::      :.::||:...|.:: :|:
Human   258 ------VTQLLPQNVHSHNSISKPQKGGPLNKEYTNWEAKETKAKDGPSIQATQKS-LPQ----- 310

  Fly   173 AGNIQN--DLHS------------------TIG----AADSEVLDDSSGSDVLILSNKETPIEIL 213
             |:.|.  :.||                  ::|    ||.|.  ||....||:.:|:|.....:.
Human   311 -GHFQERPETHSVPAPGGPAAQAAPAAPGLSLGEGREAATSS--DDEEEDDVVFVSSKPGSPLLF 372

  Fly   214 SSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSR 278
            .||.|..|  |||:     :.|.:|:..:.|..:.|.|                |..|:.|...|
Human   373 DSTLDLET--KENL-----QFPDRSVQRKVSPASGVSK----------------KVEPSDPVARR 414

  Fly   279 IKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRID---------TL 334
            :....|       ..::...||...:|.             |||||.:::|:|.         ||
Human   415 VYLTTQ-------LKQKKSTLASVNIQA-------------LPDKGQKLIKQIQELEEVLSGLTL 459

  Fly   335 RRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPR------APSIDTLDWDELSEAVNEIKPVYT 393
            ..|...:|:..|.: .|||:........|.|.||:      ...:.:|   ||..|..    |..
Human   460 SPEQGTNEKSNSQV-PQQSHFTKTTTGPPHLVPPQPLPRRGTQPVGSL---ELKSACQ----VTA 516

  Fly   394 GAQGM---------ATFNNQK------ALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQ 443
            |....         |...||.      .:|.|::..||.|||..||..|:||||.||||.|:.||
Human   517 GGSSQCYRGNTYLYAGHTNQDHVHAVWKITSEAIGQLHRSLESCPGETVVAEDPAGLKVPLLLHQ 581

  Fly   444 KHALAWMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKR 508
            |.||||:.|||.:.|:|||||||||||||||||:.:|..|| ||..|.|::|:
Human   582 KQALAWLLWRESQKPQGGILADDMGLGKTLTMIALILTQKN-QEKKEEKEKST------------ 633

  Fly   509 KSVTGWKSKGRK-DTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRDY 572
             ::| |.||... |....|||::|||||:..|::|||.:|:..||.|.::||.||:::.:.|..|
Human   634 -ALT-WLSKDDSCDFTSHGTLIICPASLIHHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVLSTY 696

  Fly   573 DIVVTTYQIVARE----------------HKSLSAVFG----------------------VKWRR 599
            |||:|||.:||:|                .::||..:|                      :.|.|
Human   697 DIVITTYSLVAKEIPTNKQEAEIPGANLNVETLSIHYGSGAVSSRAARFPLQGTSTPLLRIAWAR 761

  Fly   600 IILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWI 664
            |||||||.|:|.:.|:|:|||.|:...|||:|||||||..||:|:|||||||||||:.:.|:..:
Human   762 IILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQV 826

  Fly   665 DNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGK-LNSLPNKELRLIEISLDKEEMNVYQTVMTYSR 728
            ||.|..|..||::|.|||:|||||.||.|.|: |..||.::.:|..:.|.::|..||......||
Human   827 DNGSKKGGERLSILTKSLLLRRTKDQLDSTGRPLVILPQRKFQLHHLKLSEDEETVYNVFFARSR 891

  Fly   729 TLFAQFLHQRAERETDFNYRSDANKPTYNQI-KDPNGAYYKMHEKF-------ARMAGSKKEVKS 785
            :....:|.:...|.              ||. :.||..:.::..:|       :..|.|.:....
Human   892 SALQSYLKRHESRG--------------NQSGRSPNNPFSRVALEFGSEEPRHSEAADSPRSSTV 942

  Fly   786 HDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQS 850
            | ||..||||||.|||..|:.:.||..|.:..|        ..:.|..||:.|.:::
Human   943 H-ILSQLLRLRQCCCHLSLLKSALDPMELKGEG--------LVLSLEEQLSALTLSE-------- 990

  Fly   851 VANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVS 915
                       |.|....:..|.|.......:|...|.|:||:.::..|:.....|:..|:::||
Human   991 -----------LRDSEPSSTVSLNGTFFKMELFEGMRESTKISSLLAELEAIQRNSASQKSVIVS 1044

  Fly   916 QWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGA 980
            |||::|.::..||.|.|:...:::|::..|.|.|:|..|| .:...:|:|:||.||||||||.|.
Human  1045 QWTNMLKVVALHLKKHGLTYATIDGSVNPKQRMDLVEAFN-HSRGPQVMLISLLAGGVGLNLTGG 1108

  Fly   981 NHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAK 1045
            |||.|||:||||.||.||.||||||||:|:|:|::|:|..|||::|..||:||.|||..||:|:.
Human  1109 NHLFLLDMHWNPSLEDQACDRIYRVGQQKDVVIHRFVCEGTVEEKILQLQEKKKDLAKQVLSGSG 1173

  Fly  1046 VS-SKLTIDDLKGLFGM 1061
            .| :|||:.||:.|||:
Human  1174 ESVTKLTLADLRVLFGI 1190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	SNF2_N	442..805	CDD:278600	167/410 (41%)
		DEXDc	459..634	CDD:238005	86/213 (40%)
		HELICc	885..1014	CDD:238034	61/128 (48%)
TTF2	XP_016858039.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148404
Domainoid	1	1.000	257	1.000	Domainoid score	I2027
eggNOG	1	0.900	-	-		E1_COG0141
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	488	1.000	Inparanoid score	I1433
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	1	1.000	-	-		oto91141
orthoMCL	1	0.900	-	-		OOG6_104027
Panther	1	1.100	-	-	LDO	PTHR45626
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2250
SonicParanoid	1	1.000	-	-		X1278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790