Protein Alignment lds and CHD6

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_016883588.1
• Gene: CHD6 / 84181
• HGNCID: 19057
• Length: 2716
• Species: Homo sapiens
• Alignment Length: 1147
• Identity: 242/1147 - (21%)
• Similarity: 422/1147 - (36%)
• Gaps: 347/1147 - (30%)

  Fly     1 MSSENSEYYSDKEEDSVVNNSSLGRSRK--------------SSRLSKSSRLSKSSRPSSAGVVI 51
            |:|.|.      .|||....:.:.:.||              ..|..|..|..:...|.......
Human    77 MTSHNG------MEDSGGGGTGVKKKRKKKEPGDQEGAAKGSKDREPKPKRKREPKEPKEPRKAK 135

  Fly    52 DETQSEE--EESQSSETAESEKSDESDNSQNSQESEDSEDDSVRPSARNTKRKPLGIP------- 107
            :..:::|  |..|.....::.|..|:..::.::|.....|.:.|..:|...::....|
Human   136 EPKKAKEHKEPKQKDGAKKARKPREASGTKEAKEKRSCTDSAARTKSRKASKEQGPTPVEKKKKG 200

  Fly   108 ---SDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYT 169
               |::..|..||:|...:||.|..                |.|.|..:........:....:|.
Human   201 KRKSETTVESLELDQGLTNPSLRSP----------------EESTESTDSQKRRSGRQVKRRKYN 249

  Fly   170 TQFAGNIQNDLHSTI---GAADSEVLDDSSGSDVLILSNKETPIEILSSTDDDA----------T 221
            ......:.:|...||   ||..:..|..|:    |....:|.|       :|||          |
Human   250 EDLDFKVVDDDGETIAVLGAGRTSALSAST----LAWQAEEPP-------EDDANIIEKILASKT 303

  Fly   222 TNKENMSGPPFER-----PSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKS 281
            ..:.:...|||:.     ..::.|......|::.:..|:   |.|...:|:..:..|..:.....
Human   304 VQEVHPGEPPFDLELFYVKYRNFSYLHCKWATMEELEKD---PRIAQKIKRFRNKQAQMKHIFTE 365

  Fly   282 EDQKVVS-QVVYDEEMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRIDTLRRELAMDEQWI 345
            .|:.:.: ..|..:.:.::|..:    ||| ..|:|.|.|                     .:|.
Human   366 PDEDLFNPDYVEVDRILEVAHTK----DAE-TGEEVTHYL---------------------VKWC 404

  Fly   346 SALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLE 410
            | |..::|...    ::..::|.:....::|      :.:.|||.|    :..|:.:.||   ||
Human   405 S-LPYEESTWE----LEEDVDPAKVKEFESL------QVLPEIKHV----ERPASDSWQK---LE 451

  Fly   411 SLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWM--SWRERKLPRGGILADDMGLGKT- 472
            ..::...|.:                  |..:|...:.|:  :|..||   ..||||:||||||
Human   452 KSREYKNSNQ------------------LREYQLEGMNWLLFNWYNRK---NCILADEMGLGKTI 495

  Fly   473 --LTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASL 535
              :|.:|.:..                                   :|    ..|..|::.|.|.
Human   496 QSITFLSEIFL-----------------------------------RG----IHGPFLIIAPLST 521

  Fly   536 LRQWESEVESKVSRQKLTVCVHHGNN-------------RETKGKYLR---DYDIVVTTYQIVAR 584
            :..||.|..:..   ::...|:||:.             |:.:|..|.   .:.:|:||::::..
Human   522 ITNWEREFRTWT---EMNAIVYHGSQISRQMIQQYEMVYRDAQGNPLSGVFKFHVVITTFEMILA 583

  Fly   585 EHKSLSAVFGVKWRRIILDEAHVV--RNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLK 647
            :...|..   :.|..:|:||||.:  ||.|....|.:..|  :::..|||||:||...::::||.
Human   584 DCPELKK---IHWSCVIIDEAHRLKNRNCKLLEGLKLMAL--EHKVLLTGTPLQNSVEELFSLLN 643

  Fly   648 FLRCSPF-DDLHTWKKWIDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEIS 711
            ||..|.| .:....:::.|.|:.....:|..::|.:||||    |:.|.:.|..|.:| .:||:.
Human   644 FLEPSQFPSETAFLEEFGDLKTEEQVKKLQSILKPMMLRR----LKDDVEKNLAPKQE-TIIEVE 703

  Fly   712 LDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARM 776
            |...:...|:.::                 |.:|::.:..    .||...||
Human   704 LTNIQKKYYRAIL-----------------EKNFSFLTKG----ANQHNMPN------------- 734

  Fly   777 AGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGD----HSSDSDTPEIDLLAQL-- 835
                       ::..::.||:.|.||.||    :|.|.:.:.|    ||.|:  |:..|.|.:
Human   735 -----------LINTMMELRKCCNHPYLI----NGAEEKILEDFRKTHSPDA--PDFQLQAMIQA 782

  Fly   836 -NKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQIL 899
             .||.:.|                 .|||.
Human   783 AGKLVLID-----------------KLLPK----------------------------------- 795

  Fly   900 KTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVL 964
                |.:...|.::.||....||||.|:|.:.......::|.:....||..::.|...::.:.|.
Human   796 ----LIAGGHKVLIFSQMVRCLDILEDYLIQRRYTYERIDGRVRGNLRQAAIDRFCKPDSDRFVF 856

  Fly   965 LLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGL 1029
            ||...|||:|:||..|:..::.|..||||.:.|||.|.:|:||.|.|.:|:.:..::.|:.:...
Human   857 LLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDK 921

  Fly  1030 QDKKLDLADGVL---------TGAKVSSKLTIDDL--KGLFG 1060
            ...||.|...||         .|.:..||:.::||  ||.:|
Human   922 ASLKLGLDKAVLQDINRKGGTNGVQQLSKMEVEDLLRKGAYG 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	173/785 (22%)
		DEXHc_TTF2	439..686	CDD:350830	66/270 (24%)
CHD6	XP_016883588.1	PTZ00449	<105..374	CDD:185628	51/298 (17%)
		CD1_tandem_CHD5-9_like	289..354	CDD:349315	13/67 (19%)
		CD2_tandem_CHD5-9_like	373..431	CDD:349310	15/94 (16%)
		PLN03142	461..>986	CDD:215601	158/683 (23%)
		DEXHc_CHD6	462..683	CDD:350816	66/270 (24%)
		PHA03247	<2320..2694	CDD:223021
		BRK	2403..2438	CDD:470653