DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lds and RAD5

DIOPT Version :9

Sequence 1:	NP_524850.2	Gene:	lds / 45894	FlyBaseID:	FBgn0002542	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_197667.1	Gene:	RAD5 / 832338	AraportID:	AT5G22750	Length:	1029	Species:	Arabidopsis thaliana

Alignment Length:	978	Identity:	265/978 - (27%)
Similarity:	419/978 - (42%)	Gaps:	245/978 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 SKSLSPRSSAGASVVKTSKNLSQPTIQA---VLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMR 297
            ||.|.|.::.|    |......:|.::.   :::..|..:. ...||.:|..:.:..:|.|:::|
plant   142 SKGLKPETTPG----KRGFGRGRPALRGASDIVRFSTKDSG-EIGRIPNEWARCLLPLVRDKKIR 201

  Fly   298 -----KLAEKRVQVSDA----------EKLFEK----------------VAHKLPDKGSQIMKRI 331
                 |.|.:.:.:.|.          ..:|:|                :.|.||:. .:::..|
plant   202 IEGSCKSAPEALSIMDTILLSVSVYINSSMFQKHSATSFKTASNTAEESMFHPLPNL-FRLLGLI 265

  Fly   332 DTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQ 396
            ...:.|...::.:.....:...:..|:    ||               .|.: :|::|.:...|.
plant   266 PFKKAEFTPEDFYSKKRPLSSKDGSAI----PT---------------SLLQ-LNKVKNMNQDAN 310

  Fly   397 GMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWMSWRER------ 455
            |   ..|::.::...|.:: |.:.|..|.:.: |.|..|...|..:||.||.||:..|:
plant   311 G---DENEQCISDGDLDNI-VGVGDSSGLKEM-ETPHTLLCELRPYQKQALHWMTQLEKGNCTDE 370

  Fly   456 ---------------------------------------KLPRGGILADDMGLGKTLTMISSVLA 481
                                                   ::.|||||||.||||||:..||.:||
plant   371 AATMLHPCWEAYCLADKRELVVYLNSFTGDATIHFPSTLQMARGGILADAMGLGKTVMTISLLLA 435

  Fly   482 -----------CKNGQEMSEG-KDESSDSDSEDDKNKKRKSVTGWKSK---GRKDTRRGGTLVVC 531
                       |.|    .|| |..||..|.......|.....|:..:   .:...:.||.|:||
plant   436 HSWKAASTGFLCPN----YEGDKVISSSVDDLTSPPVKATKFLGFDKRLLEQKSVLQNGGNLIVC 496

  Fly   532 PASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVAREHKSLSA----- 591
            |.:||.||::|:|.......|:|.||:|.:|....|.|...|:|:|||.::..|....::
plant   497 PMTLLGQWKTEIEMHAKPGSLSVYVHYGQSRPKDAKLLSQSDVVITTYGVLTSEFSQENSADHEG 561

  Fly   592 VFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDD 656
            ::.|:|.||:|||||.::|.|||.|||...|....||.||||||||...|:|:||:|||..|:..
plant   562 IYAVRWFRIVLDEAHTIKNSKSQISLAAAALVADRRWCLTGTPIQNNLEDLYSLLRFLRIEPWGT 626

  Fly   657 LHTWKKWIDNKSAGGQNR----LNLLMKSLMLRRTKAQLQSDGK-LNSLPNKELRLIEISLDKEE 716
            ...|.|.:......|..|    :..::|.:||||||:....:|: :..||..:.|:|...|.:.|
plant   627 WAWWNKLVQKPFEEGDERGLKLVQSILKPIMLRRTKSSTDREGRPILVLPPADARVIYCELSESE 691

  Fly   717 MNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKK 781
            .:.|..:...|:..|.||:.|   .:...||.|
plant   692 RDFYDALFKRSKVKFDQFVEQ---GKVLHNYAS-------------------------------- 721

  Fly   782 EVKSHDILVLLLRLRQICCHPGLIDAMLDGEE-------------SQTMGDHSSDSDTPE----I 829
                  ||.|||||||.|.||.|:.:..|..|             .::.|......|.|.    .
plant   722 ------ILELLLRLRQCCDHPFLVMSRGDTAEYSDLNKLSKRFLSGKSSGLEREGKDVPSEAFVQ 780

  Fly   830 DLLAQLNK------------------------------LAITDTSTDGQQSVANAGDDGPPLL-- 862
            :::.:|.|                              ||....||.|...|.........|:
plant   781 EVVEELRKGEQGECPICLEALEDAVLTPCAHRLCRECLLASWRNSTSGLCPVCRNTVSKQELITA 845

  Fly   863 PDEARI-AKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRD 926
            |.|:|. ....||.::           ||||..:::.|:.  |:||..|:|:.||||:.||:|:.
plant   846 PTESRFQVDVEKNWVE-----------SSKITALLEELEG--LRSSGSKSILFSQWTAFLDLLQI 897

  Fly   927 HLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWN 991
            .||::..:.:.|:||:..:.|:.::.||:: :....|||:||.|||||:||..|::..::|..||
plant   898 PLSRNNFSFVRLDGTLSQQQREKVLKEFSE-DGSILVLLMSLKAGGVGINLTAASNAFVMDPWWN 961

  Fly   992 PQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSSKLTIDDLK 1056
            |.:|.||..||:|:||.|.|.|.:|:...|||:|::.:|.:|..:..|.||..:|.| ..|::||
plant   962 PAVEEQAVMRIHRIGQTKEVKIRRFIVKGTVEERMEAVQARKQRMISGALTDQEVRS-ARIEELK 1025

  Fly  1057 GLF 1059
            .||
plant  1026 MLF 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	SNF2_N	442..805	CDD:278600	134/432 (31%)
		DEXDc	459..634	CDD:238005	75/194 (39%)
		HELICc	885..1014	CDD:238034	52/128 (41%)
RAD5	NP_197667.1	UBA_like_SF	9..48	CDD:419673
		HIRAN	116..224	CDD:400928	17/86 (20%)
		HepA	<186..1028	CDD:223627	253/927 (27%)
		DEXDc_SHPRH-like	348..660	CDD:350766	103/315 (33%)
		COG5540	<765..837	CDD:227827	11/71 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	180	1.000	Domainoid score	I1043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	1	1.000	-	-		mtm1031
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920