Protein Alignment lds and CHD9

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_005256225.1
• Gene: CHD9 / 80205
• HGNCID: 25701
• Length: 2898
• Species: Homo sapiens
• Alignment Length: 1158
• Identity: 242/1158 - (20%)
• Similarity: 435/1158 - (37%)
• Gaps: 360/1158 - (31%)

  Fly     2 SSENSEYYSDKEEDSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSET 66
            |..|.::..|:      |:..|.|...||:.|..|......:.:...|:.::.|.::.||:|.:
Human   466 SFSNHQHLHDR------NHLCLQRQPPSSKKSDGSGTYTKLQNTQVRVMSEKKQRKKVESESKQ- 523

  Fly    67 AESEKSDESDNSQNSQESEDSEDDSVRPSARNTKR--KPLGIPSDSEDEEDELEQRAL------- 122
               ||::...:...::..|..|        ||..|  .|...|:.|.:.::|.:.|.:
Human   524 ---EKANRIISEAIAKAKERGE--------RNIPRVMSPENFPTASVEGKEEKKGRRMKSKPKDK 577

  Fly   123 -SPST-------------RMSITGVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFA 173
             |..|             ::.||..:.|...::.|: |.||..|            :|::|.:
Human   578 DSKKTKTCSKLKEKTKIGKLIITLGKKQKRKNESSD-EISDAEQ------------MPQHTLK-- 627

  Fly   174 GNIQNDLHSTIGAADSEVLDDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKS 238
                 |..|....::.::.......|:   ..|::..|:..|     ...|:|.:..|.|:|
Human   628 -----DQDSQKRRSNRQIKRKKYAEDI---EGKQSEEEVKGS-----MKIKKNSAPLPGEQP--- 676

  Fly   239 LSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKR 303
                                  :|..::..:           .||..:|.:::....::|.....
Human   677 ----------------------LQLFVENPS-----------EEDAAIVDKILSSRTVKKEISPG 708

  Fly   304 VQVSDAEKLFEKVAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVK------ 362
            |.: |.|:.|.|            .|....|..|.|.:||.:...|:||.    ::..|
Human   709 VMI-DTEEFFVK------------YKNYSYLHCEWATEEQLLKDKRIQQK----IKRFKLRQAQR 756

  Fly   363 ---------PTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGM-------------ATFNNQK 405
                     ...||      |.::.|.:.| |:..:...||...:             :|:..::
Human   757 AHFFADMEEEPFNP------DYVEVDRVLE-VSFCEDKDTGEPVIYYLVKWCSLPYEDSTWELKE 814

  Fly   406 ALTLESLKDLHVSLEDLPGPEVLAEDPVGL--KV----------SLMNHQKHALAWM--SWRERK 456
            .:.|..:::........|....|...|..:  |:          .|..:|...|.|:  :|..|
Human   815 DVDLAKIEEFEQLQASRPDTRRLDRPPSNIWKKIDQSRDYKNGNQLREYQLEGLNWLLFNWYNR- 878

  Fly   457 LPRGGILADDMGLGKT---LTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKG 518
              |..||||:||||||   :|.:..:|                              :||
Human   879 --RNCILADEMGLGKTIQSITFLYEIL------------------------------LTG----- 906

  Fly   519 RKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGN-------------NRETKGKYLR 570
                .||..|::.|.|.:..||.|..:...   :.|.|:||:             .|:::|:.:|
Human   907 ----IRGPFLIIAPLSTIANWEREFRTWTD---INVVVYHGSLISRQMIQQYEMYFRDSQGRIIR 964

  Fly   571 D---YDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNH--KSQSSLAVCDLRGKYRWAL 630
            .   :..::||::::......|:|   ::||.:|:||||.::|.  |....|.:.:|  :::..|
Human   965 GAYRFQAIITTFEMILGGCGELNA---IEWRCVIIDEAHRLKNKNCKLLEGLKLMNL--EHKVLL 1024

  Fly   631 TGTPIQNKELDVYALLKFLRCSPFDDLHTW-KKWIDNKSAGGQNRLNLLMKSLMLRRTKAQLQSD 694
            ||||:||...::::||.||....|....|: :::.|.|:.....:|..::|.:||||.|..::
Human  1025 TGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVE-- 1087

  Fly   695 GKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQI 759
               ..|..||..:||:.|...:...|:.::                 |.:|::.|..    ..|.
Human  1088 ---KKLAPKEETIIEVELTNIQKKYYRAIL-----------------EKNFSFLSKG----AGQT 1128

  Fly   760 KDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDS 824
            ..||                        ::..::.||:.|.||.||    .|.|.:.:|:. .|:
Human  1129 NVPN------------------------LVNTMMELRKCCNHPYLI----KGAEEKILGEF-RDT 1164

  Fly   825 DTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPS 889
            ..|           |.:|...  |..:.:||
Human  1165 YNP-----------AASDFHL--QAMIQSAG---------------------------------- 1182

  Fly   890 SKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEF 954
             |:.::.::|..  :|:...|.::.||....||||.|:|.........::|.:....||..::.|
Human  1183 -KLVLIDKLLPK--MKAGGHKVLIFSQMVRCLDILEDYLIHKRYLYERIDGRVRGNLRQAAIDRF 1244

  Fly   955 NDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCV 1019
            :..::.:.|.||...|||:|:||..|:..::.|..||||.:.|||.|.:|:||.|.|.:|:.:..
Human  1245 SKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQNKAVKVYRLVTR 1309

  Fly  1020 DTVEQRIKGLQDKKLDLADGVLT----------GAKVSSKLTIDDL--KGLFG 1060
            ::.|:.:......||.|...||.          |.:..||..|:||  :|.:|
Human  1310 NSYEREMFDRASLKLGLDKAVLQSMSGRESNVGGIQQLSKKEIEDLLRRGAYG 1362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	179/817 (22%)
		DEXHc_TTF2	439..686	CDD:350830	70/270 (26%)
CHD9	XP_005256225.1	GAT1	161..558	CDD:227928	24/109 (22%)
		ROM1	176..>362	CDD:227709
		CD1_tandem_CHD5-9_like	686..750	CDD:349315	18/80 (23%)
		CD2_tandem_CHD5-9_like	770..828	CDD:349310	9/64 (14%)
		PLN03142	811..>1480	CDD:215601	163/707 (23%)
		BRK	2483..2532	CDD:197800
		BRK	2557..2601	CDD:197800