DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lds and Ttf2

DIOPT Version :9

Sequence 1:	NP_524850.2	Gene:	lds / 45894	FlyBaseID:	FBgn0002542	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_036019252.1	Gene:	Ttf2 / 74044	MGIID:	1921294	Length:	1155	Species:	Mus musculus

Alignment Length:	1127	Identity:	368/1127 - (32%)
Similarity:	537/1127 - (47%)	Gaps:	213/1127 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSETAESEKSDESDNSQNSQE 83
            ||..|...||..:...:||:.|.  |||..|...::..:.||.:.|:.....|..|   ...|::
Mouse   158 NNEQLLDQRKEQKPKSNSRMEKD--PSSDLVATRQSGGDREEQEKSKFQPKTKKAE---GMASKQ 217

  Fly    84 SEDSEDDSVRPSARNTKRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYS 148
            ........:......::.:..|:|:..|... |.|.:.|.|    |:.|..|      :|:::..
Mouse   218 GHGEVLQGIPKGPHMSESESRGVPNKPETLR-EKETQLLVP----SVPGQNP------ESKVQKE 271

  Fly   149 DEVQEGPT---EAPTAEAVVPRYTTQFAGNIQNDL---------------------HSTIGAADS 189
            ..|...|.   |||:|: |..|...|  |.:|...                     |:|..:.||
Mouse   272 GHVSREPLKNGEAPSAQ-VTQRGLAQ--GPLQGPSKTWRPVPEAPAAPELCSGMAHHATSSSEDS 333

  Fly   190 EVLDDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSK 254
            |  ||.      :.|...:|: :..||.|.........|....:|...:.|..|..|.|
Mouse   334 E--DDG------VSSRPGSPL-LFDSTVDSQKKGSLQHSDQSVQRQMPAASGVSKKGDS------ 383

  Fly   255 NLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLFEKVAHK 319
                          :.|||.|.:......||          ...||...:|.
Mouse   384 --------------SDPAAQRANLTTQLKQK----------KGTLAAVNIQA------------- 411

  Fly   320 LPDKGSQIMKRIDTLRRELAM--------DEQWISALRVQQSN-----------VPAVRVVKPTL 365
            |||||.:::|:|..|...|:.        .::..||...:|||           ||...:.:|.:
Mouse   412 LPDKGEKLLKQIQALEDALSALALSPEQGTKEKCSAQEPEQSNITKAAAAPLHLVPPQPLPRPLI 476

  Fly   366 NPPRAPSIDTLDWDELSEAVNEIKPV---------YTGAQGMATFN-----NQKALTLESLKDLH 416
            .|..:..:.. ...|..|..::....         ..|.|.:...|     |...:|.|::.:||
Mouse   477 QPASSLGLKA-GRQETPEGASQCSGEGWPGTCCMDQVGLQALGHMNQHHLYNVWKITSEAIDELH 540

  Fly   417 VSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWMSWRERKLPRGGILADDMGLGKTLTMISSVLA 481
            .||:..||...:||||.||||.|:.|||.||||:.|||.:.|:|||||||||||||||||:.:|.
Mouse   541 RSLKSCPGETAVAEDPAGLKVPLLLHQKQALAWLLWRESQKPQGGILADDMGLGKTLTMIALILT 605

  Fly   482 CKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDT-RRGGTLVVCPASLLRQWESEVES 545
            .||.|:               .|.|:|.....|.||..... ...|||:||||||:..|::|||.
Mouse   606 KKNQQK---------------SKEKERSEPVTWLSKNDSSVFTSSGTLIVCPASLIHHWKNEVEK 655

  Fly   546 KVSRQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVARE-----------------HKSLSAVF 593
            :|:..:|.:.::||.||....|.|..||||:|||.::|:|                 ..:.:.:.
Mouse   656 RVTSNRLRIYLYHGPNRSRHAKVLSTYDIVITTYSLLAKEIPTTKQEGEVPGANLSVEGTSAPLL 720

  Fly   594 GVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLH 658
            .|.|.||||||||.|:|.:.|:|:|||.|:.:.|||:|||||||..||:|:|:|||||||||:..
Mouse   721 QVVWARIILDEAHNVKNPRVQTSIAVCKLQAQARWAVTGTPIQNNLLDMYSLMKFLRCSPFDEFS 785

  Fly   659 TWKKWIDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGK-LNSLPNKELRLIEISLDKEEMNVYQT 722
            .||..:||.|..|..||::|.|||:|||||.||.|.|| |.:||.:..:|..:.|.::|..||..
Mouse   786 LWKSQVDNGSMKGGERLSILTKSLLLRRTKDQLDSTGKPLVALPARRCQLHRLKLSEDERAVYDI 850

  Fly   723 VMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFAR-------MAGSK 780
            .:..||:....:| :|.|.....:.||            |:..:.::.::|..       .|.|:
Mouse   851 FLARSRSALQSYL-KRQEGRGSHHGRS------------PDNPFSRVAQEFGSSVSQGCPAADSQ 902

  Fly   781 KEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTST 845
            :....| :|..||||||.|||..|:.:.||..|.::.|        ..:.|..||:.|.::....
Mouse   903 RPSTVH-VLSQLLRLRQCCCHLSLLKSALDPTELESEG--------LVLSLEEQLSALTLSKVDV 958

  Fly   846 DGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDK 910
                      .:..|.:.......||.         :|:..|.|:|::.::..|:.........|
Mouse   959 ----------SEPSPTVSLNGTCFKAE---------LFDDTRRSTKVSSLLAELEAIQKGPGSQK 1004

  Fly   911 AIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGL 975
            :::||||||:|.::..||.|:.:...:::|::..|.|.|:|..|| .:...:|:|:||.||||||
Mouse  1005 SVIVSQWTSMLQVVALHLKKNRLTYATIDGSVNPKQRMDLVEAFN-HSQGPQVMLISLLAGGVGL 1068

  Fly   976 NLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGV 1040
            ||.|.|||.|||:||||.||.||.||||||||||:|:|::|:|..|||::|..||:||.|||..|
Mouse  1069 NLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQKKDVVIHRFVCEGTVEEKILQLQEKKKDLAKQV 1133

  Fly  1041 LTGAK-VSSKLTIDDLKGLFGM 1061
            |:|:: ..:|||:.|||.|||:
Mouse  1134 LSGSEGPVTKLTLADLKILFGI 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	SNF2_N	442..805	CDD:278600	161/388 (41%)
		DEXDc	459..634	CDD:238005	80/192 (42%)
		HELICc	885..1014	CDD:238034	60/128 (47%)
Ttf2	XP_036019252.1	zf-GRF	4..44	CDD:399670
		DEXHc_TTF2	563..813	CDD:350830	123/264 (47%)
		HepA	<566..1153	CDD:223627	257/643 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838525
Domainoid	1	1.000	254	1.000	Domainoid score	I2051
eggNOG	1	0.900	-	-		E1_COG0141
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	484	1.000	Inparanoid score	I1427
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	1	1.000	-	-		oto94727
orthoMCL	1	0.900	-	-		OOG6_104027
Panther	1	1.100	-	-	LDO	PTHR45626
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2250
SonicParanoid	1	1.000	-	-		X1278
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790