Protein Alignment lds and smarca2

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_031746549.1
• Gene: smarca2 / 734002
• XenbaseID: XB-GENE-1013843
• Length: 1606
• Species: Xenopus tropicalis
• Alignment Length: 1141
• Identity: 237/1141 - (20%)
• Similarity: 423/1141 - (37%)
• Gaps: 360/1141 - (31%)

  Fly    70 EKSDESD-NSQNSQESEDSEDDSVRPS-ARNTKRKPLGIPSDSEDE---------EDELEQRALS 123
            |....|| |..|:|:.......|.||| |..|....:.:|..|..:         :.:.:|..:|
 Frog   282 EAGQSSDLNVPNAQQKLVVPPPSGRPSPAPQTAPPSVSLPGPSVPQPTPGQPAPIQLQQKQNRIS 346

  Fly   124 PSTRMSITGVRPQDLSDDDSEI----EYS---------DEVQEGPTEAP-------TAEAVVPRY 168
            |..       :||.|  |..||    ||.         .|::..|...|       |.|....|.
 Frog   347 PIQ-------KPQGL--DPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRL 402

  Fly   169 TTQFAGNIQNDLHSTIGAA--DSEVLDDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPP 231
            .     |.|..|...:.|.  ....|:.:..|.....|.::|..|        |...::......
 Frog   403 L-----NFQRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLRE--------ARMTEKLEKQQK 454

  Fly   232 FERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLK-QKTSPAA--------------------PR 275
            .|:..|..........|:::.:|:..:.......| ||.|.|.                    .|
 Frog   455 IEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLSKAVATWHANTEREQKKETERIEKER 519

  Fly   276 RSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSD--------------AEKLFEKVAHKLPDKGSQ 326
            ..|:.:||::...:::..::.|:||....|..:              |:...||...|...|..:
 Frog   520 MRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTSLVWEHKKAQAAKEKKKKKKKKKAEE 584

  Fly   327 IMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVV-----KPTLNP--PRAPSIDTLDWDELSEA 384
            ..:.:.:   .|.||.:.|.. ..|.|::| |:|:     |..|.|  |:|..::|  |.|::..
 Frog   585 NAEGVGS---GLGMDGELIDE-SSQMSDLP-VKVIHTETGKVLLAPEAPKASQLET--WLEMNPG 642

  Fly   385 VNEIKPVYTGAQGMAT-----------------------FNNQKALTLESLKDLHVSLEDLPGPE 426
            . |:.| .:.::|.::                       .|.:..:..::.:.:..:.:|:....
 Frog   643 Y-EVAP-RSDSEGSSSEYEEEEDEEESSRLDTEEKKRLGLNTEDNVKHDAKQIIETAKQDVDDEY 705

  Fly   427 VLAED----------------------PVGLKVSLMNHQKHALAWM-SWRERKLPRGGILADDMG 468
            .:.||                      .:.:..||.::|...|.|| |.....|  .|||||:||
 Frog   706 SMQEDARQSQSYYGVAHAVTERVEKQSSLLINGSLKHYQIQGLEWMVSLFNNNL--NGILADEMG 768

  Fly   469 LGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPA 533
            ||||:..|:.:......:.::                                   |..|::.|.
 Frog   769 LGKTIQTIALITYLMEHKRLN-----------------------------------GPYLIIVPL 798

  Fly   534 SLLRQWESEVES------KVS-------RQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVARE 585
            |.|..|..|.:.      |::       |:.|...:..|.           :::::|||:.:.::
 Frog   799 STLSNWLYEFDKWAPSVVKIAYKGTPAMRRSLVPQLRTGK-----------FNVLLTTYEYIIKD 852

  Fly   586 HKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKY----RWALTGTPIQNKELDVYALL 646
            ...|:.   ::|:.:|:||.|.::||..:.:..   |...|    |..|||||:|||..:::|||
 Frog   853 KHILAK---IRWKYMIVDEGHRMKNHHCKLTQV---LNTHYVAPRRILLTGTPLQNKLPELWALL 911

  Fly   647 KFLRCSPFDDLHTWKKWIDNKSA-GGQ-------------NRLNLLMKSLMLRRTKAQLQSDGKL 697
            .||..:.|....|:::|.:...| .|:             .||:.:::..:|||.|.:::|
 Frog   912 NFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVES---- 972

  Fly   698 NSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAE--RETDFNYRSDANKPTYNQIK 760
             .||.|...:|     |.:|:..|.::         :.|.:|:  ..||
 Frog   973 -QLPEKVEYVI-----KCDMSALQKIL---------YRHMQAKGILLTD---------------- 1006

  Fly   761 DPNGAYYKMHEKFARMAGSKKEVK----SHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHS 821
                             ||:|:.|    :..::..:::||:||.||.:...:   |||  ..:|
 Frog  1007 -----------------GSEKDKKGKGGAKTLMNTIMQLRKICNHPFIFQHI---EES--FAEH- 1048

  Fly   822 SDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFN-- 884
                                                                  |..||.:.|
 Frog  1049 ------------------------------------------------------LGYSNGIINGP 1059

  Fly   885 -LHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQ 948
             |:|.|.|..::.:||..  |::::.:.::..|.||::.|:.|:.:......|.|:||...::|.
 Frog  1060 DLYRTSGKFELLDRILPK--LRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRA 1122

  Fly   949 DIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVII 1013
            .::..||:..:...:.|||..|||:||||..|:.:::.|..|||..:.|||||.:|:||:..|.:
 Frog  1123 SLLKRFNEEGSPFFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRV 1187

  Fly  1014 YKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSSK 1049
            .:...|::||::|......||::...|:.......|
 Frog  1188 LRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQK 1223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	181/860 (21%)
		DEXHc_TTF2	439..686	CDD:350830	65/278 (23%)
smarca2	XP_031746549.1	Atrophin-1	31..>467	CDD:460830	43/206 (21%)
		QLQ	175..209	CDD:462622
		HSA	453..525	CDD:214727	11/71 (15%)
		BRK	605..648	CDD:462196	15/47 (32%)
		PLN03142	697..>1218	CDD:215601	152/688 (22%)
		DEXHc_SMARCA2	717..967	CDD:350821	68/303 (22%)
		SnAC	1293..1360	CDD:464219
		Bromo_SNF2L2	1416..1522	CDD:99947