Protein Alignment lds and Chd8

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_963999.2
• Gene: Chd8 / 67772
• MGIID: 1915022
• Length: 2582
• Species: Mus musculus
• Alignment Length: 1142
• Identity: 242/1142 - (21%)
• Similarity: 434/1142 - (38%)
• Gaps: 360/1142 - (31%)

  Fly    41 SSRPSSAGVVIDETQSEEE-------ESQSSETAESEKSDESDNSQNSQESEDSE----DDSVRP 94
            ||:.:|:|:.:.:..|..|       .|.:..||.....:|:...::.::.|.:.    :...|.
Mouse   410 SSQGASSGLSVVKVLSASEVAALSSPASCAPHTAGKTGMEENRRLEHQKKQEKANRIVAEAIARA 474

  Fly    95 SARNTKRKPL-----GIPSDSEDEEDELEQRALSPSTRM-----------------------SIT 131
            .||..:..|.     .:||...:||.|.::|..|...|:                       :||
Mouse   475 RARGEQNIPRVLNEDELPSVRPEEEGEKKRRKKSSGERLKEEKPKKSKTAAASKTKGKSKLNTIT 539

  Fly   132 GV----RPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVL 192
            .|    |.::.|.|:|::|..      |.::|                 :.|..|:|
Mouse   540 PVVGKKRKRNTSSDNSDVEVM------PAQSP-----------------REDEESSI-------- 573

  Fly   193 DDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLS 257
             ....|:..:...|.|....:..|||: ...:.:::||....|   :.|..      |:.....:
Mouse   574 -QKRRSNRQVKRKKYTEDLDIKITDDE-EEEEVDVTGPIKPEP---ILPEP------VQEPDGET 627

  Fly   258 QPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRV---QVSDAEKLFEK---- 315
            .|::|..::..:           .||..:|.:|:   .|| :.:|.:   |.::||:.|.|
Mouse   628 LPSMQFFVENPS-----------EEDAAIVDKVL---SMR-VVKKELPSGQYTEAEEFFVKYKNY 677

  Fly   316 ---------VAHKLPDKG-SQIMKRIDT----LRRELAMDEQ-----WISALRV--------QQS 353
                     ::....||. .|.:||..|    :|.....||:     ::...|:        :.:
Mouse   678 SYLHCEWATISQLEKDKRIHQKLKRFKTKMAQMRHFFHEDEEPFNPDYVEVDRILDESHSVDKDN 742

  Fly   354 NVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVS 418
            ..|.:..:....:.|...|    .| ||.|.|:|                .|....:.::..|..
Mouse   743 GEPVIYYLVKWCSLPYEDS----TW-ELKEDVDE----------------GKIREFKRIQSRHPE 786

  Fly   419 LEDLPGPEVLAEDPVGL------KVSLMNHQKHALAWM--SWRERKLPRGGILADDMGLGKTLTM 475
            |..:..|:..|...:.|      :..|..:|...:.|:  :|..|   :..||||:||||||:..
Mouse   787 LRRVNRPQANAWKKLELSHEYKNRNQLREYQLEGVNWLLFNWYNR---QNCILADEMGLGKTIQS 848

  Fly   476 ISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWE 540
            |:.:....|                           .|         ..|..||:.|.|.:..||
Mouse   849 IAFLQEVYN---------------------------VG---------IHGPFLVIAPLSTITNWE 877

  Fly   541 SEVESKVSRQKLTVCVHHGN-------------NRETKGKYL---RDYDIVVTTYQIVAREHKSL 589
            .|..:..   ::...|:||:             .::::|:.:   ..:|.::||::::..:...|
Mouse   878 REFNTWT---EMNTIVYHGSLASRQMIQQYEMYCKDSRGRLIPGAYKFDALITTFEMILSDCPEL 939

  Fly   590 SAVFGVKWRRIILDEAHVV--RNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCS 652
            ..   ::||.:|:||||.:  ||.|...||...||  :::..|||||:||...::::||.||..|
Mouse   940 RE---IEWRCVIIDEAHRLKNRNCKLLDSLKHMDL--EHKVLLTGTPLQNTVEELFSLLHFLEPS 999

  Fly   653 PF-DDLHTWKKWIDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEE 716
            .| .:....|.:.|.|:.....:|..::|.:||||    |:.|.:.|..|.:| .:||:.|...:
Mouse  1000 QFPSESEFLKDFGDLKTEEQVQKLQAILKPMMLRR----LKEDVEKNLAPKQE-TIIEVELTNIQ 1059

  Fly   717 MNVYQTVMTYSRTLFAQFLHQRAERETDFNYRS----DANKPTYNQIKDPNGAYYKMHEKFARMA 777
            ...|:.::                 |.:|::.|    ..|.|
Mouse  1060 KKYYRAIL-----------------EKNFSFLSKGAGHTNMP----------------------- 1084

  Fly   778 GSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITD 842
                     ::|..::.||:.|.||.||    :|.|.:               :|.:..:..
Mouse  1085 ---------NLLNTMMELRKCCNHPYLI----NGAEEK---------------ILMEFREAC--- 1118

  Fly   843 TSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLH---RPSSKINMVIQILKTSIL 904
                             .::|.:                 |:|.   |.:.|:.::.::|..  |
Mouse  1119 -----------------HIIPQD-----------------FHLQAMVRSAGKLVLIDKLLPK--L 1147

  Fly   905 KSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLT 969
            |:...|.::.||....||||.|:|.:.......::|.:....||..::.|:..::.:.|.||...
Mouse  1148 KAGGHKVLIFSQMVRCLDILEDYLIQRRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTR 1212

  Fly   970 AGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKL 1034
            |||:|:||..|:..::.|..||||.:.|||.|.:|:||.|.|.:|:.:..::.|:.:......||
Mouse  1213 AGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKL 1277

  Fly  1035 DL----------ADGVLTGAKVSSKLTIDDL--KGLF 1059
            .|          .||.:||.:..||..|:||  ||.:
Mouse  1278 GLDKAVLQSMSGRDGNITGIQQFSKKEIEDLLRKGAY 1314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	182/831 (22%)
		DEXHc_TTF2	439..686	CDD:350830	68/267 (25%)
Chd8	NP_963999.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..111
		SP1-4_N	61..>421	CDD:425404	4/10 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	136..155
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	253..283
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..377
		PTZ00121	<449..624	CDD:173412	38/216 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..585		25/141 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	598..617		4/22 (18%)
		CD1_tandem_CHD5-9_like	640..705	CDD:349315	17/68 (25%)
		CD2_tandem_CHD5-9_like	723..781	CDD:349310	11/78 (14%)
		PLN03142	812..>1411	CDD:215601	156/662 (24%)
		DEAD-like_helicase_N	813..1034	CDD:475120	68/267 (25%)
		DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03071	950..953		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1694..1715
		Interaction with FAM124B. /evidence=ECO:0000255|HAMAP-Rule:MF_03071	1791..2304
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1990..2019
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2045..2120
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2187..2233
		BRK	2311..2354	CDD:462196
		BRK	2381..2420	CDD:470653
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2486..2582