Protein Alignment lds and Smarca2

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001392062.1
• Gene: Smarca2 / 67155
• MGIID: 99603
• Length: 1601
• Species: Mus musculus
• Alignment Length: 1211
• Identity: 231/1211 - (19%)
• Similarity: 425/1211 - (35%)
• Gaps: 426/1211 - (35%)

  Fly    57 EEEESQSSETAESEKSDESDNSQNSQESEDSEDDSVRPSARNTKRKPLGIPSDSEDEEDELEQRA 121
            ::::.|..:..:.::..:....|..|..:..:....:|                :.::.:.:|.|
Mouse   216 QQQQQQQQQQQQQQQQQQQQQQQQQQPQQPQQQAQAQP----------------QQQQQQQQQPA 264

  Fly   122 LSPSTRMSITGVRPQD--LSDDDSEIEYSDEVQEG-PTEAPTAEAVVPRYTTQFAGNIQNDLHST 183
            |....|.|..|   |:  ||...:..:.|.....| |:.||.| ||.|..|.....::|...
Mouse   265 LVSYNRPSGPG---QELLLSGQSAPQKLSAPAPSGRPSPAPQA-AVQPTATAVPGPSVQQPA--- 322

  Fly   184 IGAADSEVLDDSSGSDVLILSNKET------------PIEILSSTD-------DDATTNKENMSG 229
                      ....|.||.|..|::            |:|||...:       .......|::.|
Mouse   323 ----------PGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQELESLPG 377

  Fly   230 --PPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKT------SPAAPRRSRIKSEDQKV 286
              ||..|...::..::   ..::...:.|.|..:..:.:..|      |.|..|..|....:.::
Mouse   378 SLPPDLRTKATVELKA---LRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARM 439

  Fly   287 VSQVVYDEEMRKLAEKRVQ----------VSDAEKLFEKVAHKLPDKGSQIMKRIDT-------- 333
            ..::   |:.:|:.::|.:          :....|.|::....:..|..::.|.:.|
Mouse   440 TEKL---EKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTERE 501

  Fly   334 ------------LRRELAMDEQWIS-----------ALRVQQSNVPAVRVV-------------- 361
                        :||.:|.||:...           |..:||::.....:.
Mouse   502 QKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKE 566

  Fly   362 ------------------KPTLNP-----------------------------PRAPSIDTLD-W 378
                              :|.|.|                             |.||....|| |
Mouse   567 KKKRRRRKKKAEENAEGGEPALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAW 631

  Fly   379 DELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAE------------- 430
            .|::... |:.|.....:..:.:..:......|.::....:...|..|.::|
Mouse   632 LEMNPGY-EVAPRSDSEESESDYEEEDEEEESSRQETEEKILLDPNSEEVSEKDAKQIIETAKQD 695

  Fly   431 --DPVGLKVS-----------------------------LMNHQKHALAWM-SWRERKLPRGGIL 463
              |...::.|                             |.::|...|.|| |.....|  .|||
Mouse   696 VDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYNNNL--NGIL 758

  Fly   464 ADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTL 528
            ||:||||||:..|:.:......:.::                                   |..|
Mouse   759 ADEMGLGKTIQTIALITYLMEHKRLN-----------------------------------GPYL 788

  Fly   529 VVCPASLLRQWESEVES------KVS-------RQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQ 580
            ::.|.|.|..|..|.:.      |:|       |:.|...:..|.           :::::|||:
Mouse   789 IIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGK-----------FNVLLTTYE 842

  Fly   581 IVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKY----RWALTGTPIQNKELD 641
            .:.::...|:.   ::|:.:|:||.|.::||..:.:..   |...|    |..|||||:|||..:
Mouse   843 YIIKDKHILAK---IRWKYMIVDEGHRMKNHHCKLTQV---LNTHYVAPRRILLTGTPLQNKLPE 901

  Fly   642 VYALLKFLRCSPFDDLHTWKKWIDNKSA-GGQ-------------NRLNLLMKSLMLRRTKAQLQ 692
            ::|||.||..:.|....|:::|.:...| .|:             .||:.:::..:|||.|.:::
Mouse   902 LWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVE 966

  Fly   693 SDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAE--RETDFNYRSDANKPT 755
            |     .||.|...:|     |.:|:..|.::         :.|.:|:  ..||
Mouse   967 S-----QLPEKVEYVI-----KCDMSALQKIL---------YRHMQAKGILLTD----------- 1001

  Fly   756 YNQIKDPNGAYYKMHEKFARMAGSKKEVK----SHDILVLLLRLRQICCHPGLIDAMLDGEESQT 816
                                  ||:|:.|    :..::..:::||:||.||.:...:   |||
Mouse  1002 ----------------------GSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHI---EES-- 1039

  Fly   817 MGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNP 881
            ..:|                                                       |..||.
Mouse  1040 FAEH-------------------------------------------------------LGYSNG 1049

  Fly   882 VFN---LHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIP 943
            |.|   |:|.|.|..::.:||..  |::::.:.::..|.||::.|:.|:.:......|.|:||..
Mouse  1050 VINGAELYRASGKFELLDRILPK--LRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTK 1112

  Fly   944 VKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQK 1008
            .::|..::.:||:..:|..:.|||..|||:||||..|:.:::.|..|||..:.|||||.:|:||:
Mouse  1113 SEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQ 1177

  Fly  1009 KNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSSK 1049
            ..|.:.:...|::||::|......||::...|:.......|
Mouse  1178 NEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQK 1218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	184/941 (20%)
		DEXHc_TTF2	439..686	CDD:350830	66/278 (24%)
Smarca2	NP_001392062.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..77
		PHA03378	<74..393	CDD:223065	38/209 (18%)
		QLQ	173..207	CDD:462622
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..346		29/162 (18%)
		HSA	447..519	CDD:214727	9/71 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	562..603		3/40 (8%)
		BRK	600..643	CDD:462196	8/43 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	638..683		5/45 (11%)
		DEXHc_SMARCA2	712..962	CDD:350821	68/303 (22%)
		PLN03142	731..>1213	CDD:215601	151/649 (23%)
		DEGH box	862..865		2/2 (100%)
		SnAC	1270..1337	CDD:464219
		Bromodomain	1344..>1430	CDD:445827
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1357..1394
		Bromo_SNF2L2	1393..1517	CDD:99947
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1517..1601