DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lds and HLTF

DIOPT Version :9

Sequence 1:	NP_524850.2	Gene:	lds / 45894	FlyBaseID:	FBgn0002542	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_011511393.1	Gene:	HLTF / 6596	HGNCID:	11099	Length:	1013	Species:	Homo sapiens

Alignment Length:	883	Identity:	242/883 - (27%)
Similarity:	354/883 - (40%)	Gaps:	284/883 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 PVYTGAQGMATFNNQKALTLESLK-DLHVSLEDLPGPEVLAE-DPV-GLKVSLMNHQKHALAWMS 451
            ||:...|          :|.|.|| :.....|||...:...| :|. .::..|:.|||.|||||.
Human   198 PVHAAVQ----------MTTEQLKTEFDKLFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMV 252

  Fly   452 WRE--RKLP--------------------------RGGILADDMGLGKTLTMISSVLA------- 481
            .||  ::||                          .|||||||||||||||.|:.:|.
Human   253 SRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIAVILTNFHDGRP 317

  Fly   482 ------------------------------------------CKNGQEMSEGKDES--------- 495
                                                      |.....:|:.|::|
Human   318 LPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSS 382

  Fly   496 -------------SDSDSED-------DKNK-KRKSVTGWKSKGR-------------------- 519
                         ..||||:       .|.| |.|:|.. ::|||
Human   383 SRPKRRKTAVQYIESSDSEEIETSELPQKMKGKLKNVQS-ETKGRAKAGSSKVIEDVAFACALTS 446

  Fly   520 -------KDTRRGG-----------------TLVVCPASLLRQWESEVESKV-SRQKLTVCVHHG 559
                   |..::|.                 ||::||.|:|..|..:....: |...|...|::|
Human   447 SVPTTKKKMLKKGACAVEGSKKTDVEERPRTTLIICPLSVLSNWIDQFGQHIKSDVHLNFYVYYG 511

  Fly   560 NNRETKGKYLRDYDIVVTTYQIVAREH--KSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDL 622
            .:|..:...|...|||:|||.|:..::  |..|.:..::|.|:||||.|.:||..:|.:.||.||
Human   512 PDRIREPALLSKQDIVLTTYNILTHDYGTKGDSPLHSIRWLRVILDEGHAIRNPNAQQTKAVLDL 576

  Fly   623 RGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNK----SAGGQNRLNLLMKSLM 683
            ..:.||.||||||||...|:::||.||:..||.|...|.:.|...    ..||..||..|:|::.
Human   577 ESERRWVLTGTPIQNSLKDLWSLLSFLKLKPFIDREWWHRTIQRPVTMGDEGGLRRLQSLIKNIT 641

  Fly   684 LRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYR 748
            |||||........:..||.:::.:..|:|..||..:||:|....|...
Human   642 LRRTKTSKIKGKPVLELPERKVFIQHITLSDEERKIYQSVKNEGRATI----------------- 689

  Fly   749 SDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAML--DG 811
                           |.|:......|..|         |:|.|||||||||||..|:...:  :|
Human   690 ---------------GRYFNEGTVLAHYA---------DVLGLLLRLRQICCHTYLLTNAVSSNG 730

  Fly   812 EESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGP----------PLLPDEA 866
            ..:.::|     :||||     :|.|..|..     .:.:.::|.|..          |::...|
Human   731 PSAFSLG-----NDTPE-----ELRKKLIRK-----MKLILSSGSDEECAICLDSLTVPVITHCA 780

  Fly   867 RI----------------AKA--SKNLLKRSN----PVFNLHR-----------PSSKINMVIQI 898
            .:                ||.  .:|.:...|    |...|.|           .|||||.::..
Human   781 HVFCKPCICQVIQNEQPHAKCPLCRNDIHEDNLLECPPEELARDSEKKSDMEWTSSSKINALMHA 845

  Fly   899 LKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEF-NDRNNQKR 962
            |.....|:.:.|::||||:|:.|.::...|...|.....|:|::..|.|.:.:..| |.......
Human   846 LTDLRKKNPNIKSLVVSQFTTFLSLIEIPLKASGFVFTRLDGSMAQKKRVESIQCFQNTEAGSPT 910

  Fly   963 VLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIK 1027
            ::||||.||||||||..|:.:.|:|..|||..|.|..||.:|:|||:.|||.||:..|:||:.:.
Human   911 IMLLSLKAGGVGLNLSAASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENML 975

  Fly  1028 GLQDKKLDLADGV----------LTGAKVSSKLTIDDL 1055
            .:|:||.:||.|.          :..||::...|:.||
Human   976 KIQNKKRELAAGAFGTKKPNADEMKQAKINEIRTLIDL 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	SNF2_N	442..805	CDD:278600	141/520 (27%)
		DEXDc	459..634	CDD:238005	76/300 (25%)
		HELICc	885..1014	CDD:238034	52/140 (37%)
HLTF	XP_011511393.1	HIRAN	60..155	CDD:285949
		DEXDc	238..>320	CDD:214692	30/81 (37%)
		DEXDc	288..>320	CDD:238005	17/31 (55%)
		SNF2_N	472..722	CDD:278600	94/290 (32%)
		DEXDc	<478..588	CDD:238005	41/109 (38%)
		RING	763..808	CDD:238093	5/44 (11%)
		Helicase_C	836..954	CDD:278689	45/117 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3486
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.870