Protein Alignment lds and SMARCA2

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_003061.3
• Gene: SMARCA2 / 6595
• HGNCID: 11098
• Length: 1590
• Species: Homo sapiens
• Alignment Length: 1139
• Identity: 225/1139 - (19%)
• Similarity: 410/1139 - (35%)
• Gaps: 378/1139 - (33%)

  Fly    34 KSSRLSKSSRPSSAGVVIDETQSEEEESQSSETAESEKSDESDNSQNSQESEDSEDDSVRPSA-- 96
            |.||:|...:|..    :|..:..:|.....:...:.:..|.:|...|...:.....:|...|
Human   324 KQSRISPIQKPQG----LDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALR 384

  Fly    97 -----RNTKRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEI----------- 145
                 |..:::.:.........|..|..:|...|.|.::...|..:..:...:|
Human   385 LLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKHQ 449

  Fly   146 EYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGA--ADSE------------------ 190
            ||.:.:.:...:       ...|....||.||. |...:..  |::|
Human   450 EYLNSILQHAKD-------FKEYHRSVAGKIQK-LSKAVATWHANTEREQKKETERIEKERMRRL 506

  Fly   191 VLDDSSGSDVLILSNKETPIEILSSTDDDATTNKENM-----------SGPPFERPSKSLSPRSS 244
            :.:|..|...||...|:..:..|....|:...|..|:           ......|..|.....:.
Human   507 MAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEENAE 571

  Fly   245 AGASV-------VKTSKNLSQPTIQAVLKQKT-----SPAAPRRSRI--------------KSED 283
            .|.|.       :..|..:|...:: |...:|     .|.||:.|::              :|:.
Human   572 GGESALGPDGEPIDESSQMSDLPVK-VTHTETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDS 635

  Fly   284 QKVVSQVVYDEE------MRKLAEKRVQVS-DAEKLFEKVAHKLPDKGSQIMKRIDTLRRELAMD 341
            ::  |...|:||      .|:..|:::.:. ::|::.||.|.::          |:|.::::..:
Human   636 EE--SDSDYEEEDEEEESSRQETEEKILLDPNSEEVSEKDAKQI----------IETAKQDVDDE 688

  Fly   342 EQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKA 406
            .....:.|..||.......:                    ||.|.:                |.|
Human   689 YSMQYSARGSQSYYTVAHAI--------------------SERVEK----------------QSA 717

  Fly   407 LTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWM-SWRERKLPRGGILADDMGLG 470
            |.:..                          :|.::|...|.|| |.....|  .|||||:||||
Human   718 LLING--------------------------TLKHYQLQGLEWMVSLYNNNL--NGILADEMGLG 754

  Fly   471 KTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASL 535
            ||:..|:.:......:.::                                   |..|::.|.|.
Human   755 KTIQTIALITYLMEHKRLN-----------------------------------GPYLIIVPLST 784

  Fly   536 LRQWESEVES------KVS-------RQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVAREHK 587
            |..|..|.:.      |:|       |:.|...:..|.           :::::|||:.:.::..
Human   785 LSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGK-----------FNVLLTTYEYIIKDKH 838

  Fly   588 SLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKY----RWALTGTPIQNKELDVYALLKF 648
            .|:.   ::|:.:|:||.|.::||..:.:..   |...|    |..|||||:|||..:::|||.|
Human   839 ILAK---IRWKYMIVDEGHRMKNHHCKLTQV---LNTHYVAPRRILLTGTPLQNKLPELWALLNF 897

  Fly   649 LRCSPFDDLHTWKKWIDNKSA-GGQ-------------NRLNLLMKSLMLRRTKAQLQSDGKLNS 699
            |..:.|....|:::|.:...| .|:             .||:.:::..:|||.|.:::|     .
Human   898 LLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVES-----Q 957

  Fly   700 LPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAE--RETDFNYRSDANKPTYNQIKDP 762
            ||.|...:|     |.:|:..|.::         :.|.:|:  ..||
Human   958 LPEKVEYVI-----KCDMSALQKIL---------YRHMQAKGILLTD------------------ 990

  Fly   763 NGAYYKMHEKFARMAGSKKEVK----SHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSD 823
                           ||:|:.|    :..::..:::||:||.||.:...:   |||  ..:|
Human   991 ---------------GSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHI---EES--FAEH--- 1032

  Fly   824 SDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFN---L 885
                                                                |..||.|.|   |
Human  1033 ----------------------------------------------------LGYSNGVINGAEL 1045

  Fly   886 HRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDI 950
            :|.|.|..::.:||..  |::::.:.::..|.||::.|:.|:.:......|.|:||...::|..:
Human  1046 YRASGKFELLDRILPK--LRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAAL 1108

  Fly   951 VNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYK 1015
            :.:||:..:|..:.|||..|||:||||..|:.:::.|..|||..:.|||||.:|:||:..|.:.:
Human  1109 LKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLR 1173

  Fly  1016 FMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSSK 1049
            ...|::||::|......||::...|:.......|
Human  1174 LCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQK 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	171/801 (21%)
		DEXHc_TTF2	439..686	CDD:350830	66/278 (24%)
SMARCA2	NP_003061.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71
		Atrophin-1	<46..>450	CDD:460830	20/129 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..176
		QLQ	173..207	CDD:462622
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..334		4/9 (44%)
		HSA	436..508	CDD:214727	11/79 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	551..592		5/40 (13%)
		BRK	589..632	CDD:462196	7/43 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	627..672		8/46 (17%)
		DEXHc_SMARCA2	701..951	CDD:350821	74/365 (20%)
		PLN03142	720..>1202	CDD:215601	151/675 (22%)
		DEGH box	851..854		2/2 (100%)
		SnAC	1259..1326	CDD:464219
		Bromodomain	1333..>1419	CDD:445827
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1344..1383
		Bromo_SNF2L2	1382..1506	CDD:99947
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1506..1590