Protein Alignment lds and SMARCA1

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001269803.1
• Gene: SMARCA1 / 6594
• HGNCID: 11097
• Length: 1070
• Species: Homo sapiens
• Alignment Length: 883
• Identity: 205/883 - (23%)
• Similarity: 332/883 - (37%)
• Gaps: 304/883 - (34%)

  Fly   233 ERPSKSLSPRSSAGASVV-----------KTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKV 286
            |:|..|.|....|.|:..           |..||:|.      .:.|.:..||     |||.:
Human    27 EQPGPSTSQEEGAAAAATEATAATEKGEKKKEKNVSS------FQLKLAAKAP-----KSEKE-- 78

  Fly   287 VSQVVYDEEMRKLAEKRVQ-VSDAEKLF----EKVAHKLP---------------DKGSQIMKRI 331
             ....|:|:|:....||.: :....:||    :..|.|.|               |:...::...
Human    79 -MDPEYEEKMKADRAKRFEFLLKQTELFAHFIQPSAQKSPTSPLNMKLGRPRIKKDEKQSLISAG 142

  Fly   332 DTLRR--ELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTG 394
            |...|  |...||:.:|..| :.||| .:|.                          |:.|.|..
Human   143 DYRHRRTEQEEDEELLSESR-KTSNV-CIRF--------------------------EVSPSYVK 179

  Fly   395 AQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWM-SWRERKLP 458
            .                            ||             |.::|...|.|: |..|..:
Human   180 G----------------------------GP-------------LRDYQIRGLNWLISLYENGV- 202

  Fly   459 RGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTR 523
             .|||||:|||||||..|:.:...|:.:.:.
Human   203 -NGILADEMGLGKTLQTIALLGYLKHYRNIP---------------------------------- 232

  Fly   524 RGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRD------YDIVVTTYQIV 582
             |..:|:.|.|.|..|.:|.:..|...::...|   .:::.:..::||      :|:.||:|::|
Human   233 -GPHMVLVPKSTLHNWMNEFKRWVPSLRVICFV---GDKDARAAFIRDEMMPGEWDVCVTSYEMV 293

  Fly   583 AREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLK 647
            .:| ||:...|  .||.:::||||.::|.||:.|..|.:.:...|..|||||:||...:::|||.
Human   294 IKE-KSVFKKF--HWRYLVIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLN 355

  Fly   648 FLRCSPFDDLHTWKKWIDNKSAGGQ----NRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLI 708
            ||....|:....:..|.|.|:..|.    .||:.::|..:|||.|..::     .|||.|:...|
Human   356 FLLPDVFNSADDFDSWFDTKNCLGDQKLVERLHAVLKPFLLRRIKTDVE-----KSLPPKKEIKI 415

  Fly   709 EISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKF 773
            .:.|.|.:...|..::.               ::.|              :.:.:|...||.
Human   416 YLGLSKMQREWYTKILM---------------KDID--------------VLNSSGKMDKMR--- 448

  Fly   774 ARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKL 838
                          :|.:|::||:.|.||.|.|
Human   449 --------------LLNILMQLRKCCNHPYLFD-------------------------------- 467

  Fly   839 AITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSI 903
                           ..:.|||...||..::.:.|                    ||:.....:.
Human   468 ---------------GAEPGPPYTTDEHIVSNSGK--------------------MVVLDKLLAK 497

  Fly   904 LKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQD------------IVNEFND 956
            ||....:.::.||.|.:||||.|:....|.....|:|..|.:.|:|            .:..||.
Human   498 LKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREDKFLEVEFLGQREAIEAFNA 562

  Fly   957 RNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDT 1021
            .|:.|.:.:||..|||:|:||..|:.::|.|..||||::.||.||.:|:||||.|.:::.:..:|
Human   563 PNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNT 627

  Fly  1022 VEQRIKGLQDKKLDLADGVLTGAKV----SSKLTIDDL 1055
            ||:||....:.||.|...|:...::    |:||..:::
Human   628 VEERIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEM 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	185/798 (23%)
		DEXHc_TTF2	439..686	CDD:350830	73/257 (28%)
SMARCA1	NP_001269803.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..82		16/68 (24%)
		PLN03142	87..1069	CDD:215601	187/809 (23%)
		DEAH box	311..314		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	831..861