Protein Alignment lds and Chd8

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_006251970.1
• Gene: Chd8 / 65027
• RGDID: 620696
• Length: 2589
• Species: Rattus norvegicus
• Alignment Length: 1142
• Identity: 242/1142 - (21%)
• Similarity: 434/1142 - (38%)
• Gaps: 360/1142 - (31%)

  Fly    41 SSRPSSAGVVIDETQSEEE-------ESQSSETAESEKSDESDNSQNSQESEDSE----DDSVRP 94
            ||:.:|:|:.:.:..|..|       .|.:..||.....:|:...::.::.|.:.    :...|.
  Rat   408 SSQGASSGLSVVKVLSASEVAALSSPASCAPHTAGKTGMEENRRLEHQKKQEKANRIVAEAIARA 472

  Fly    95 SARNTKRKPL-----GIPSDSEDEEDELEQRALSPSTRM-----------------------SIT 131
            .||..:..|.     .:||...:||.|.::|..|...|:                       :||
  Rat   473 RARGEQNIPRVLNEDELPSVRPEEEGEKKRRKKSSGERLKEEKPKKSKTAAASKTKGKSKLNTIT 537

  Fly   132 GV----RPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVL 192
            .|    |.::.|.|:|::|..      |.::|                 :.|..|:|
  Rat   538 PVVGKKRKRNTSSDNSDVEVM------PAQSP-----------------REDEESSI-------- 571

  Fly   193 DDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLS 257
             ....|:..:...|.|....:..|||: ...:.:::||....|   :.|..      |......:
  Rat   572 -QKRRSNRQVKRKKYTEDLDIKITDDE-EEEEVDVTGPIKPEP---ILPEP------VPEPDGET 625

  Fly   258 QPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRV---QVSDAEKLFEK---- 315
            .|::|..::..:           .||..:|.:|:   .|| :.:|.:   |.::||:.|.|
  Rat   626 LPSMQFFVENPS-----------EEDAAIVDKVL---SMR-VVKKELPSGQYTEAEEFFVKYKNY 675

  Fly   316 ---------VAHKLPDKG-SQIMKRIDT----LRRELAMDEQ-----WISALRV--------QQS 353
                     ::....||. .|.:||..|    :|.....||:     ::...|:        :.:
  Rat   676 SYLHCEWATISQLEKDKRIHQKLKRFKTKMAQMRHFFHEDEEPFNPDYVEVDRILDESHSVDKDN 740

  Fly   354 NVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVS 418
            ..|.:..:....:.|...|    .| ||.|.|:|                .|....:.::..|..
  Rat   741 GEPVIYYLVKWCSLPYEDS----TW-ELKEDVDE----------------GKIREFKRIQSRHPE 784

  Fly   419 LEDLPGPEVLAEDPVGL------KVSLMNHQKHALAWM--SWRERKLPRGGILADDMGLGKTLTM 475
            |:.:..|:..|...:.|      :..|..:|...:.|:  :|..|   :..||||:||||||:..
  Rat   785 LKRVNRPQANAWKKLELSHEYKNRNQLREYQLEGVNWLLFNWYNR---QNCILADEMGLGKTIQS 846

  Fly   476 ISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWE 540
            |:.:....|                           .|         ..|..||:.|.|.:..||
  Rat   847 IAFLQEVYN---------------------------VG---------IHGPFLVIAPLSTITNWE 875

  Fly   541 SEVESKVSRQKLTVCVHHGN-------------NRETKGKYL---RDYDIVVTTYQIVAREHKSL 589
            .|..:..   ::...|:||:             .::::|:.:   ..:|.::||::::..:...|
  Rat   876 REFNTWT---EMNTIVYHGSLASRQMIQQYEMYCKDSRGRLIPGAYKFDALITTFEMILSDCPEL 937

  Fly   590 SAVFGVKWRRIILDEAHVV--RNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCS 652
            ..   ::||.:|:||||.:  ||.|...||...||  :::..|||||:||...::::||.||..|
  Rat   938 RE---IEWRCVIIDEAHRLKNRNCKLLDSLKHMDL--EHKVLLTGTPLQNTVEELFSLLHFLEPS 997

  Fly   653 PF-DDLHTWKKWIDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEE 716
            .| .:....|.:.|.|:.....:|..::|.:||||    |:.|.:.|..|.:| .:||:.|...:
  Rat   998 QFPSESEFLKDFGDLKTEEQVQKLQAILKPMMLRR----LKEDVEKNLAPKQE-TIIEVELTNIQ 1057

  Fly   717 MNVYQTVMTYSRTLFAQFLHQRAERETDFNYRS----DANKPTYNQIKDPNGAYYKMHEKFARMA 777
            ...|:.::                 |.:|::.|    ..|.|
  Rat  1058 KKYYRAIL-----------------EKNFSFLSKGAGHTNMP----------------------- 1082

  Fly   778 GSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITD 842
                     ::|..::.||:.|.||.||    :|.|.:               :|.:..:..
  Rat  1083 ---------NLLNTMMELRKCCNHPYLI----NGAEEK---------------ILMEFREAC--- 1116

  Fly   843 TSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLH---RPSSKINMVIQILKTSIL 904
                             .::|.:                 |:|.   |.:.|:.::.::|..  |
  Rat  1117 -----------------HIIPQD-----------------FHLQAMVRSAGKLVLIDKLLPK--L 1145

  Fly   905 KSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLT 969
            |:...|.::.||....||||.|:|.:.......::|.:....||..::.|:..::.:.|.||...
  Rat  1146 KAGGHKVLIFSQMVRCLDILEDYLIQRRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTR 1210

  Fly   970 AGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKL 1034
            |||:|:||..|:..::.|..||||.:.|||.|.:|:||.|.|.:|:.:..::.|:.:......||
  Rat  1211 AGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKL 1275

  Fly  1035 DL----------ADGVLTGAKVSSKLTIDDL--KGLF 1059
            .|          .||.:||.:..||..|:||  ||.:
  Rat  1276 GLDKAVLQSMSGRDGNITGIQQFSKKEIEDLLRKGAY 1312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	182/831 (22%)
		DEXHc_TTF2	439..686	CDD:350830	68/267 (25%)
Chd8	XP_006251970.1	PHA03247	<68..279	CDD:223021
		SP1-4_N	143..>442	CDD:425404	8/33 (24%)
		PTZ00121	<447..622	CDD:173412	38/216 (18%)
		CD1_tandem_CHD5-9_like	638..703	CDD:349315	17/68 (25%)
		CD2_tandem_CHD5-9_like	721..779	CDD:349310	11/78 (14%)
		PLN03142	810..>1409	CDD:215601	156/662 (24%)
		DEXHc_CHD8	811..1032	CDD:350818	68/267 (25%)
		BRK	2317..2360	CDD:462196
		BRK	2387..2426	CDD:470653