Protein Alignment lds and CHD8

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001164100.1
• Gene: CHD8 / 57680
• HGNCID: 20153
• Length: 2581
• Species: Homo sapiens
• Alignment Length: 1142
• Identity: 242/1142 - (21%)
• Similarity: 437/1142 - (38%)
• Gaps: 360/1142 - (31%)

  Fly    41 SSRPSSAGVVIDETQSEEEESQSSETAESE-----KSDESDNSQNSQESEDSEDDSV------RP 94
            ||:.:|:|:.:.:..|..|.:..|..|.|.     |:...:|.:...:.:..:.:.:      |.
Human   408 SSQGASSGLSVVKVLSASEVAALSSPASSAPHSGGKTGMEENRRLEHQKKQEKANRIVAEAIARA 472

  Fly    95 SARNTKRKPL-----GIPSDSEDEEDELEQRALSPSTRM-----------------------SIT 131
            .||..:..|.     .:||...:||.|.::|..|...|:                       :||
Human   473 RARGEQNIPRVLNEDELPSVRPEEEGEKKRRKKSAGERLKEEKPKKSKTSGASKTKGKSKLNTIT 537

  Fly   132 GV----RPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVL 192
            .|    |.::.|.|:|::|..      |.::|                 :.|..|:|
Human   538 PVVGKKRKRNTSSDNSDVEVM------PAQSP-----------------REDEESSI-------- 571

  Fly   193 DDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLS 257
             ....|:..:...|.|....:..|||: ...:.:::||....|   :.|..      |:.....:
Human   572 -QKRRSNRQVKRKKYTEDLDIKITDDE-EEEEVDVTGPIKPEP---ILPEP------VQEPDGET 625

  Fly   258 QPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRV---QVSDAEKLFEK---- 315
            .|::|..::..:           .||..:|.:|:   .|| :.:|.:   |.::||:.|.|
Human   626 LPSMQFFVENPS-----------EEDAAIVDKVL---SMR-IVKKELPSGQYTEAEEFFVKYKNY 675

  Fly   316 ---------VAHKLPDKG-SQIMKRIDT----LRRELAMDEQ-----WISALRV--------QQS 353
                     ::....||. .|.:||..|    :|.....||:     ::...|:        :.:
Human   676 SYLHCEWATISQLEKDKRIHQKLKRFKTKMAQMRHFFHEDEEPFNPDYVEVDRILDESHSIDKDN 740

  Fly   354 NVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVS 418
            ..|.:..:....:.|...|    .| ||.|.|:|                .|....:.::..|..
Human   741 GEPVIYYLVKWCSLPYEDS----TW-ELKEDVDE----------------GKIREFKRIQSRHPE 784

  Fly   419 LEDLPGPEVLAEDPVGL------KVSLMNHQKHALAWM--SWRERKLPRGGILADDMGLGKTLTM 475
            |:.:..|:..|...:.|      :..|..:|...:.|:  :|..|   :..||||:||||||:..
Human   785 LKRVNRPQASAWKKLELSHEYKNRNQLREYQLEGVNWLLFNWYNR---QNCILADEMGLGKTIQS 846

  Fly   476 ISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWE 540
            |:.:....|                           .|         ..|..||:.|.|.:..||
Human   847 IAFLQEVYN---------------------------VG---------IHGPFLVIAPLSTITNWE 875

  Fly   541 SEVESKVSRQKLTVCVHHGN-------------NRETKGKYL---RDYDIVVTTYQIVAREHKSL 589
            .|..:..   ::...|:||:             .::::|:.:   ..:|.::||::::..:...|
Human   876 REFNTWT---EMNTIVYHGSLASRQMIQQYEMYCKDSRGRLIPGAYKFDALITTFEMILSDCPEL 937

  Fly   590 SAVFGVKWRRIILDEAHVV--RNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCS 652
            ..   ::||.:|:||||.:  ||.|...||...||  :::..|||||:||...::::||.||..|
Human   938 RE---IEWRCVIIDEAHRLKNRNCKLLDSLKHMDL--EHKVLLTGTPLQNTVEELFSLLHFLEPS 997

  Fly   653 PF-DDLHTWKKWIDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEE 716
            .| .:....|.:.|.|:.....:|..::|.:||||    |:.|.:.|..|.:| .:||:.|...:
Human   998 QFPSESEFLKDFGDLKTEEQVQKLQAILKPMMLRR----LKEDVEKNLAPKQE-TIIEVELTNIQ 1057

  Fly   717 MNVYQTVMTYSRTLFAQFLHQRAERETDFNYRS----DANKPTYNQIKDPNGAYYKMHEKFARMA 777
            ...|:.::                 |.:|::.|    ..|.|
Human  1058 KKYYRAIL-----------------EKNFSFLSKGAGHTNMP----------------------- 1082

  Fly   778 GSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITD 842
                     ::|..::.||:.|.||.||    :|.|.:.:
Human  1083 ---------NLLNTMMELRKCCNHPYLI----NGAEEKIL------------------------- 1109

  Fly   843 TSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLH---RPSSKINMVIQILKTSIL 904
              |:.:::.        .::|.:                 |:|.   |.:.|:.::.::|..  |
Human  1110 --TEFREAC--------HIIPHD-----------------FHLQAMVRSAGKLVLIDKLLPK--L 1145

  Fly   905 KSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLT 969
            |:...|.::.||....||||.|:|.:.......::|.:....||..::.|:..::.:.|.||...
Human  1146 KAGGHKVLIFSQMVRCLDILEDYLIQRRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTR 1210

  Fly   970 AGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKL 1034
            |||:|:||..|:..::.|..||||.:.|||.|.:|:||.|.|.:|:.:..::.|:.:......||
Human  1211 AGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKL 1275

  Fly  1035 DL----------ADGVLTGAKVSSKLTIDDL--KGLF 1059
            .|          .||.:||.:..||..|:||  ||.:
Human  1276 GLDKAVLQSMSGRDGNITGIQQFSKKEIEDLLRKGAY 1312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	182/831 (22%)
		DEXHc_TTF2	439..686	CDD:350830	68/267 (25%)
CHD8	NP_001164100.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..114
		PHA03247	<68..280	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	253..283
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..392
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..582		31/184 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..615		4/22 (18%)
		CD1_tandem_CHD5-9_like	638..703	CDD:349315	17/68 (25%)
		CD2_tandem_CHD5-9_like	721..779	CDD:349310	11/78 (14%)
		PLN03142	810..>1409	CDD:215601	156/662 (24%)
		DEXHc_CHD8	811..1032	CDD:350818	68/267 (25%)
		DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03071	948..951		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1692..1712
		Interaction with FAM124B. /evidence=ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:23285124	1789..2302
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1991..2116
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2189..2229
		BRK	2310..2354	CDD:197800
		BRK	2379..2419	CDD:197800
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2481..2581