DRSC/TRiP Functional Genomics Resources

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Protein Alignment lds and EP400

DIOPT Version :10

Sequence 1:NP_524850.2 Gene:lds / 45894 FlyBaseID:FBgn0002542 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_056224.3 Gene:EP400 / 57634 HGNCID:11958 Length:3123 Species:Homo sapiens


Alignment Length:1180 Identity:220/1180 - (18%)
Similarity:382/1180 - (32%) Gaps:453/1180 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSSENSEYYSDKEEDSVVNN--SSLGRS--------------RKSSRLSKSSRLSKSSRP----S 45
            :..|..|...::|:..|:|:  .:|..|              ::...:..:....:|.||    .
Human   425 IEEEEEEEEEEEEKSEVINDEQQALAGSLVAGAGSTVETDLFKRQQAMPSTGMAEQSKRPRLEVG 489

  Fly    46 SAGVVIDETQSEE--EESQSSETAESEKSDESDNSQ--NSQESEDSEDDSVRPSARNT------- 99
            ..|||.....::.  ...|...||:.........:|  ..::|:...|.|..|..:|.       
Human   490 HQGVVFQHPGADAGVPLQQLMPTAQGGMPPTPQAAQLAGQRQSQQQYDPSTGPPVQNAASLHTPL 554

  Fly   100 -----KRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEG--PTE 157
                 :..|.|:|:           .|||.:.:.:   .:|| :.:..::::...:.|:.  |..
Human   555 PQLPGRLPPAGVPT-----------AALSSALQFA---QQPQ-VVEAQTQLQIPVKTQQPNVPIP 604

  Fly   158 APTAE--AVVPRYTTQFAGNIQNDLH-STIGAADSEVLDDSSGSDVLILSNKETPIEILSSTDDD 219
            ||.:.  .:.|....|.|      || .|.|....:....||...  ::::...|::        
Human   605 APPSSQLPIPPSQPAQLA------LHVPTPGKVQVQASQLSSLPQ--MVASTRLPVD-------- 653

  Fly   220 ATTNKENMSGPPFERP-----SKSLSPRSSAG-------ASVVK-----TSKNLSQPTIQ---AV 264
                    ..||..||     :.||:|.|.:|       :|.|.     |:|.||..|.:   .|
Human   654 --------PAPPCPRPLPTSSTSSLAPVSGSGPGPSPARSSPVNRPSSATNKALSPVTSRTPGVV 710

  Fly   265 LKQKTSPAAPRRSRIKSEDQK---VVSQVVYD--------------------------------- 293
            ....|.|.:|.::...|:|..   :..|:..:                                 
Human   711 ASAPTKPQSPAQNATSSQDSSQDTLTEQITLENQVHQRIAELRKAGLWSQRRLPKLQEAPRPKSH 775

  Fly   294 -----EEMRKLA-----EKRVQVSDAEKLFEKVAHKLPDKGSQIMKRIDTLRRELAMDEQWISAL 348
                 |||:.:|     |:|.:|:.|:||...|.....:|         .||.|....|:.....
Human   776 WDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVVRHHEEK---------QLREERGKKEEQSRLR 831

  Fly   349 RVQQ----------SNVPAVRVVK----------------------PTLNP-------------- 367
            |:..          ||:..|..:|                      ..|.|              
Human   832 RIAASTAREIECFWSNIEQVVEIKLRVELEEKRKKALNLQKVSRRGKELRPKGFDALQESSLDSG 896

  Fly   368 ----PRAPSI-----------DTLDWDELSEAV------------------NEIKPVYTGA---- 395
                .|..||           :|::.:|.:|.|                  .::..:|.||    
Human   897 MSGRKRKASISLTDDEVDDEEETIEEEEANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFLPS 961

  Fly   396 --------QGMATFNNQKALTL----ESLKDLHV---------------------SLEDLPGPEV 427
                    .|..|...:.|...    ||.|||.:                     :.:|:.....
Human   962 SQWPRPKPDGEDTSGEEDADDCPGDRESRKDLVLIDSLFIMDQFKAAERMNIGKPNAKDIADVTA 1026

  Fly   428 LAED--PVG---------------LKVSLMNHQKHALAWMSWRERKLPRGGILADDMGLGKTLTM 475
            :||.  |.|               |..:|.::||..|.|::...|| ...|||||:.|||||:.:
Human  1027 VAEAILPKGSARVTTSVKFNAPSLLYGALRDYQKIGLDWLAKLYRK-NLNGILADEAGLGKTVQI 1090

  Fly   476 IS--SVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQ 538
            |:  :.|||..|                           .|          |..|||..:..:.:
Human  1091 IAFFAHLACNEG---------------------------NW----------GPHLVVVRSCNILK 1118

  Fly   539 WESEVESKVSRQKLTVCVHHGNNRETKGKYL-----RDYDIVVTTYQIVAREHKSLSAVFGVKWR 598
            ||.|::......|:...:  |::||.|.|..     ..:.:.:|:|   .:..:.|:|...|:|:
Human  1119 WELELKRWCPGLKILSYI--GSHRELKAKRQEWAEPNSFHVCITSY---TQFFRGLTAFTRVRWK 1178

  Fly   599 RIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFL--------RCSPFD 655
            .:::||...|:....:...||..|:.:.|..|..:|:.|..|:::.::.||        ..||  
Human  1179 CLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNTFLELWTMVHFLVPGISRPYLSSP-- 1241

  Fly   656 DLHTWKKWIDNKSAGGQN-------RLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLD 713
                    :...|...|:       ||:.:.:..:|||||..::     ..|..|...:::..|.
Human  1242 --------LRAPSEESQDYYHKVVIRLHRVTQPFILRRTKRDVE-----KQLTKKYEHVLKCRLS 1293

  Fly   714 KEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAG 778
            ..:..:|:.|                                   |..|               |
Human  1294 NRQKALYEDV-----------------------------------ILQP---------------G 1308

  Fly   779 SKKEVKS-H--DILVLLLRLRQICCHPGLIDAMLDGEESQTMG----------------DHSSDS 824
            :::.:|| |  ::|.:|:||::||.||||::....| .|...|                |...::
Human  1309 TQEALKSGHFVNVLSILVRLQRICNHPGLVEPRHPG-SSYVAGPLEYPSASLILKALERDFWKEA 1372

  Fly   825 DTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDE--------ARIAKASKNLLKRSNP 881
            |....||:...||:...:.....::.:       |..|.:|        ||.|.|.....:...|
Human  1373 DLSMFDLIGLENKITRHEAELLSKKKI-------PRKLMEEISTSAAPAARPAAAKLKASRLFQP 1430

  Fly   882 VFNLHRPSSK 891
            |....:|..:
Human  1431 VQYGQKPEGR 1440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ldsNP_524850.2 HepA 287..1041 CDD:440319 154/830 (19%)
DEXHc_TTF2 439..686 CDD:350830 62/268 (23%)
EP400NP_056224.3 EP400_N 1..469 CDD:434938 7/43 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..65
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 125..154
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..261
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..359
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 509..558 8/48 (17%)
PAT1 518..>780 CDD:401645 51/300 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..622 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 648..734 23/101 (23%)
HSA 764..835 CDD:214727 17/79 (22%)
HepA 849..>1338 CDD:440319 114/596 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 879..931 9/51 (18%)
Interactions with RUVBL1 and RUVBL2 915..1329 101/521 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 961..988 3/26 (12%)
DEAD-like_helicase_N 1055..1271 CDD:475120 62/268 (23%)
DEAH box-like 1183..1186 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1431..1546 2/10 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1751..1771
SF2_C_SNF 1861..1986 CDD:350180
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2083..2108
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2251..2275
Interaction with ZNF42. /evidence=ECO:0000250 2488..2753
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2488..2566
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2629..2652
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2785..2833
SP1-4_N <2840..3065 CDD:425404
PRK12323 <3004..>3123 CDD:481241
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3079..3123
Blue background indicates that the domain is not in the aligned region.

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