Protein Alignment lds and chd2

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_021323365.1
• Gene: chd2 / 569795
• ZFINID: ZDB-GENE-050419-256
• Length: 1817
• Species: Danio rerio
• Alignment Length: 1159
• Identity: 251/1159 - (21%)
• Similarity: 440/1159 - (37%)
• Gaps: 324/1159 - (27%)

  Fly     2 SSENSEYYSDKEEDSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSET 66
            :|.:.|......|....:.|..|..:..||.|:|:..|.|...|.:|...:.::|.:..:|..:.
Zfish    22 NSASEESNRSGSESGSQSESEQGSEKAQSRHSESNSTSDSESHSESGSESNGSKSHQSSAQVKDK 86

  Fly    67 AESEKSDESD--------------------NSQNSQE----------SEDSE-DDSVRPSARNTK 100
            ...:|.:.:|                    :|::.||          |.||| :.|.|.|:|..|
Zfish    87 PVRKKDNLADVKKVHKKMWEEHPDVYGVRRSSRSRQEPARLNIGAEGSSDSEGESSKRKSSRQKK 151

  Fly   101 RKPLGIPSDSEDEED--------ELEQR----------ALSPSTRMSIT-------GVRPQDLSD 140
            ::......||.||||        |.||.          |..|.|:.|.:       ..|.|:.||
Zfish   152 KENTWKDDDSNDEEDVEEETSSSESEQEEKKVRSRRLPARRPQTKSSASKQSQKGRKQRKQESSD 216

  Fly   141 DDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADS-EVLDDSSGSDVLILS 204
            :|.:.:..||......:.....|....|...     |||..:     || ::::.:.|::.....
Zfish   217 EDDDDDDDDEEDTPKRQTRRRAATKVSYKED-----QNDFET-----DSDDLIEMAEGAEEQQDD 271

  Fly   205 NKETPIEILSSTDDDATTNKENMSGP-----PFER---PSKSLSPRSSAGAS--VVK-------- 251
            :.||..:::     |..|.|:..:|.     ..|.   |.....|....|.:  ::|
Zfish   272 DSETIEKVV-----DTRTGKKGATGASTTLYAIEENGDPGADFDPEKEEGETQFLIKWKGWSYIH 331

  Fly   252 ----TSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKL 312
                :..:|:|..::.:.|.:       ..:.|:|:.....:....|::.....::...:|..|.
Zfish   332 NTWESVDSLTQQKVKGMKKLE-------NFKKKNEELNAWLKKASPEDLEYYNCQQELTNDLSKQ 389

  Fly   313 FEKVAHKLPDKGSQIMKRIDTLRRELAMDE-----QWISALRVQQSNVPAVRVVKPTLNPPRAPS 372
            |:.:...:..:..:.....||...:.:..|     :|:..                    |.|
Zfish   390 FQIIERVIATRTGKSQATSDTPSHKSSSGEPEYLCKWMGL--------------------PYA-- 432

  Fly   373 IDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGL-- 435
              ...|::.:    .||..:...  :.:|:|:.:......||..| |:..|....|.:.|..:
Zfish   433 --ECTWEDSA----LIKKKFQAC--IDSFHNRNSSKTVPSKDCKV-LKQRPRFVPLKKQPSYIGD 488

  Fly   436 -KVSLMNHQKHALAWM--SW-RERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESS 496
             .:.|.::|...:.|:  || |...:    ||||:||||||:..||.:....:..::
Zfish   489 ENLELRDYQLDGVNWLAHSWCRCNSV----ILADEMGLGKTIQTISFLSYLFHQHQL-------- 541

  Fly   497 DSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNN 561
                                       .|..:||.|.|.|..|:.|.::..  ..:.|.|:.|:
Zfish   542 ---------------------------YGPFIVVVPLSTLTSWQREFDTWA--PDMNVVVYLGD- 576

  Fly   562 RETKGKYLRDYD------------IVVTTYQIVAREHKSLSAVFG-VKWRRIILDEAHVVRNHKS 613
             .|..|.:|||:            .::|||:|:.::    ..|.| :.|..:.:||||.::|..|
Zfish   577 -VTSRKTIRDYEWINPQTKRIKFNALLTTYEILLKD----KGVLGNINWAFLGVDEAHRLKNDDS 636

  Fly   614 QSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAG---GQNRL 675
            .....:.|.|..:|..:||||:||...::::||.||....|:   :|:.:.|....|   |...|
Zfish   637 LLYKTLIDFRSNHRLLITGTPLQNSLKELWSLLHFLMSDKFE---SWEDFEDEHGKGRDNGYQSL 698

  Fly   676 NLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAE 740
            :.:::..:|||.|..::     .|||.|..:::.:.:..::...|:.::|.:
Zfish   699 HKVLEPFLLRRVKKDVE-----KSLPAKVEQILRVDMSAQQKQFYKWILTRN------------- 745

  Fly   741 RETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLI 805
                                      :|...|..|  ||     |...|.:::.|::.|.|..||
Zfish   746 --------------------------FKALSKGTR--GS-----SSGFLNIVMELKKCCNHAFLI 777

  Fly   806 DAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAK 870
            ....|||           :|.|:..|                 ||:...|  |..:|.|:
Zfish   778 KQPEDGE-----------NDAPQEHL-----------------QSLVRGG--GKLVLLDK----- 807

  Fly   871 ASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVAT 935
                ||.|                         ||...::.::.||...:||||.|:||......
Zfish   808 ----LLTR-------------------------LKDRGNRVLIFSQMVRMLDILADYLSMKRYQF 843

  Fly   936 LSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQD 1000
            ..|:|:|..:.|:..::.||...::....|||..|||:|:||..|:.:::.|..||||.:.|||.
Zfish   844 QRLDGSIKGELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQA 908

  Fly  1001 RIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSSKLTIDD 1054
            |.:|:||||.|.||:.:...|||:.|.....||:.|...|:.....:.:..:|:
Zfish   909 RAHRIGQKKQVNIYRLVTKGTVEEDIIERAKKKMVLDHLVIQRMDTTGRTVLDN 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	176/780 (23%)
		DEXHc_TTF2	439..686	CDD:350830	67/265 (25%)
chd2	XP_021323365.1	CD1_tandem_CHD1-2_like	272..356	CDD:349313	14/95 (15%)
		CD2_tandem_CHD1-2_like	389..456	CDD:349308	11/96 (11%)
		DEAD-like_helicase_N	473..709	CDD:475120	70/285 (25%)
		PLN03142	479..>1054	CDD:215601	158/649 (24%)
		CDH1_2_SANT_HL1	1137..1225	CDD:477096
		DUF4208	1455..1549	CDD:464035
		PTZ00449	<1503..>1796	CDD:185628