Protein Alignment lds and SMARCAD1

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001121901.1
• Gene: SMARCAD1 / 56916
• HGNCID: 18398
• Length: 1028
• Species: Homo sapiens
• Alignment Length: 1181
• Identity: 261/1181 - (22%)
• Similarity: 428/1181 - (36%)
• Gaps: 332/1181 - (28%)

  Fly    18 VNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSETAESEKSDESDNSQNSQ 82
            :|..:|.|.|...|.........:.:||..|.....:.|.|||:...|.:.:       |:.:|.
Human     1 MNLFNLDRFRFEKRNKIEEAPEATPQPSQPGPSSPISLSAEEENAEGEVSRA-------NTPDSD 58

  Fly    83 ESEDSEDDSVRPSARNTKRKP-------------LGIPSDSED---------------------- 112
            .:|.:||.|| |...:.:||.             :.:.|||||
Human    59 ITEKTEDSSV-PETPDNERKASISYFKNQRGIQYIDLSSDSEDVVSPNCSNTVQEKTFNKDTVII 122

  Fly   113 ----EEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFA 173
                .||| |.:.|....|.          :||.||:|...|:::      ..:|.:......|.
Human   123 VSEPSEDE-ESQGLPTMARR----------NDDISELEDLSELED------LKDAKLQTLKELFP 170

  Fly   174 GNIQNDLHSTI-------GAADSEVL---DDSSGSDVLILSNKETPIEILSSTDDDATTNKENMS 228
            ....|||...|       ||..:.:|   |...|.....||:...|.|.....||.:........
Human   171 QRSDNDLLKLIESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTRLDH 235

  Fly   229 GPPFERPSKSLSPRSSAGASVVKTSK---NLSQPTIQAVLKQK----TSPAAPRRSRIKSEDQKV 286
            |......::|.|......:.|:|..|   |..:..::.|||:.    |......:...:.:|.:.
Human   236 GEESNESAESSSNWEKQESIVLKLQKEFPNFDKQELREVLKEHEWMYTEALESLKVFAEDQDMQY 300

  Fly   287 VSQ--VVYDEEMRKLAEKRVQVSDAEKLFEKVAHKLP-----------------------DKGSQ 326
            |||  |...:|:...::...:.:...||.:|.:.|..                       |.||.
Human   301 VSQSEVPNGKEVSSRSQNYPKNATKTKLKQKFSMKAQNGFNKKRKKNVFNPKRVVEDSEYDSGSD 365

  Fly   327 IMKRIDTLRRELAMDEQWISALRVQQSN--------VPAVRVVKPTLNPPRAPSIDTLDWDELSE 383
            :..         ::||.:.|...|.:..        :....:.:.||.|..:        .:.::
Human   366 VGS---------SLDEDYSSGEEVMEDGYKGKILHFLQDASIGELTLIPQCS--------QKKAQ 413

  Fly   384 AVNEIKPVYTGAQGMATFNNQKAL-------------------TLESLKDLHVSL----EDLPG- 424
            .:.|::|          ||:.:||                   ||...:|:.:.|    ||:..
Human   414 KITELRP----------FNSWEALFTKMSKTNGLSEDLIWHCKTLIQERDVVIRLMNKCEDISNK 468

  Fly   425 -------------------PEVLAEDPVGLKVSLMNHQKHALAWMSWRERKLPRGGILADDMGLG 470
                               |.:|.:     .:||..:||..|.|:: ...|....|||||:||||
Human   469 LTKQVTMLTGNGGGWNIEQPSILNQ-----SLSLKPYQKVGLNWLA-LVHKHGLNGILADEMGLG 527

  Fly   471 KTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASL 535
            ||:..|:.:     .....||.:                               |..|:|.|||.
Human   528 KTIQAIAFL-----AYLYQEGNN-------------------------------GPHLIVVPAST 556

  Fly   536 LRQWESEVESKVSRQKLTVCVHHGNNRETK-------GKYLRDYDIVVTTYQIVAREHKSLSAVF 593
            :..|..||  .:....|.|..::|:..|.|       .:| .||:::||||..........|...
Human   557 IDNWLREV--NLWCPTLKVLCYYGSQEERKQIRFNIHSRY-EDYNVIVTTYNCAISSSDDRSLFR 618

  Fly   594 GVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDD-- 656
            .:|....|.||.|:::|..|.....:..:....|..|||||:||..|::.:||.|:....|..
Human   619 RLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSST 683

  Fly   657 ------LHTWKKWIDNKSAGGQNRL---NLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISL 712
                  ..:..|..|.:|...:.|:   ..::|..:|||.|.::     |..||.|:.|:...::
Human   684 SEIRRMFSSKTKSADEQSIYEKERIAHAKQIIKPFILRRVKEEV-----LKQLPPKKDRIELCAM 743

  Fly   713 DKEEMNVYQTVMTYSRTLFAQFLHQRAERETD-----FNYRSDANKPTYNQIKDPNGAYYKMHEK 772
            .:::..:|..:....:......:   .|:.|:     ...|..||.|..::      .||.. ||
Human   744 SEKQEQLYLGLFNRLKKSINNLV---TEKNTEMCNVMMQLRKMANHPLLHR------QYYTA-EK 798

  Fly   773 FARMAGSKKEVKSHDILVLLLRLRQIC-CHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLN 836
            ...|:            .|:|:....| .:|.||     .|:.:.|.|.       |:.:|.:..
Human   799 LKEMS------------QLMLKEPTHCEANPDLI-----FEDMEVMTDF-------ELHVLCKQY 839

  Fly   837 KLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKT 901
            : .|.:...|                                    .:|...|.|..::..||
Human   840 R-HINNFQLD------------------------------------MDLILDSGKFRVLGCIL-- 865

  Fly   902 SILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLL 966
            |.||...|:.::.||:|.:||||...|.......|.|:|...:..|..:::||| .:....|.||
Human   866 SELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFN-TDMDIFVFLL 929

  Fly   967 SLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQD 1031
            |..|||:|:||..||.::|.|:..||..:.||:||.:||||.|.|::.|.:...|:|:.:..:..
Human   930 STKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQ 994

  Fly  1032 KKLDLADGVLT 1042
            :||.|...:.|
Human   995 QKLKLEQDMTT 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	191/853 (22%)
		DEXHc_TTF2	439..686	CDD:350830	68/264 (26%)
SMARCAD1	NP_001121901.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82		23/88 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	203..251		10/47 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	302..328		4/25 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..373		4/27 (15%)
		HepA	<496..999	CDD:440319	157/621 (25%)
		DEGH box	628..631		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000255	721..738		7/21 (33%)
		DEGD box	1007..1010