DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lds and hltf

DIOPT Version :9

Sequence 1:	NP_524850.2	Gene:	lds / 45894	FlyBaseID:	FBgn0002542	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_005163433.1	Gene:	hltf / 564651	ZFINID:	ZDB-GENE-030131-3306	Length:	942	Species:	Danio rerio

Alignment Length:	1005	Identity:	259/1005 - (25%)
Similarity:	405/1005 - (40%)	Gaps:	290/1005 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 TSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAE--KLFEKV--------------- 316
            :|...||.:.|...|  |.|.:...:|:..|.|...|..:||  .||..:
Zfish    10 SSSTPPRYAFIDFMD--VGSTMTLSQELANLTEDAGQELEAEGNVLFGSIQGLIVGLRYYTGAVN 72

  Fly   317 ----------AHKLPDKGSQIM-----KRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKP--T 364
                      .|...|:.:.::     .::..:::|||....:|     ..:.:..|..:.|  .
Zfish    73 KGEMVSLVREPHNPYDRNAVMVANVYGSQVGHIKKELAAAMAYI-----MDNKLARVEGIVPYGE 132

  Fly   365 LNPPRAPSIDTLDW--DELSEAVNEI------KPVYTGAQ----------GMATFNNQKALTLES 411
            .|....|.|.|. |  :|..|.||.:      ...:.|..          |::|..:...|:.|.
Zfish   133 KNKFSMPVILTF-WGKEENREVVNNLMIGFGFNLDFRGGSSQTSLGRDLLGLSTKLSAIPLSAEE 196

  Fly   412 LKDLHVSL-EDLPGPEVLAEDPV-GLKVSLMNHQKHALAWMSWRE-------------------- 454
            ||:....| :||...:....:|. .:...|::|||.||:|||.||
Zfish   197 LKNAFDKLFDDLMEDKTKEMEPAEAVCTPLLSHQKQALSWMSSRENSNDLPPFWEENKGLYFNVL 261

  Fly   455 -----RKLPR---GGILADDMGLGKTLTMISSVLA------------CKNGQEMSEGKDESSDS- 498
                 :|.|.   |||||||||||||||.|:.:::            || |..|...|.:.:.|
Zfish   262 TNFAVKKRPEKVLGGILADDMGLGKTLTTIALIVSNFHNGKPLPLEKCK-GPSMPSAKRKQATSK 325

  Fly   499 ----DSE---------------DD-----------KNKKRKSVTGWKS----------------- 516
                |||               ||           |..|:||....|:
Zfish   326 EKGVDSEESQESMGLSPLKRLHDDTVRENGPQKKTKTTKKKSANTKKAVVLLDDVEFAAALECSS 390

  Fly   517 ----KGRKDTRRG-------------GTLVVCPASLLRQWESEVESKVSRQKLTVCV--HHGNNR 562
                ..:|..::.             .||:|||.|:|..|..:.|..: |..:||.|  ::|:.|
Zfish   391 SQVVPSKKCVKKSSVPSEISAGSVARATLIVCPLSVLSNWLDQFEQHI-RTDVTVKVYLYYGSER 454

  Fly   563 ETKGKYLRDYDIVVTTYQIVARE--HKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGK 625
            ......|.:.|:|:|||.:::.:  :|:.|.:..|||.|::|||.|||||..:..|.||.:|:.:
Zfish   455 NRSVSLLSEQDVVLTTYNVLSSDFGNKASSPLHNVKWLRVVLDEGHVVRNPNALQSKAVLELQSE 519

  Fly   626 YRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQ----NRLNLLMKSLMLRR 686
            .||.|:||||||...|::.||.||:..|||....|.:.|......|.    ..|..|:|.:.|||
Zfish   520 RRWILSGTPIQNSLKDLFMLLSFLKLKPFDVKEWWSRIIQRPVTMGDRVGLKNLQALVKGITLRR 584

  Fly   687 TKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDA 751
            ||........|..||.:.:.:..::|...|...|:.|....:.:.
Zfish   585 TKNSKVGGRTLVQLPERRVFVQYVTLSGMEREKYERVKGEGKNIV-------------------- 629

  Fly   752 NKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQT 816
                        |.|::.....|..|         |:|.:|:||||.||||.|:
Zfish   630 ------------GRYFQEGTFMANYA---------DVLTILMRLRQCCCHPSLV----------- 662

  Fly   817 MGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDD----------GPPLL--------- 862
             |:::: :|.|...  ::|.:..|...:.     |.|:|.|          ..|::
Zfish   663 -GNYTA-ADVPGTP--SELRERLIQKITL-----VLNSGSDEECAICLDSLRQPVITYCAHVFCR 718

  Fly   863 PDEARIAKASKNLLK-----------------------RSNPVFNLHRPSSKINMVIQILKTSIL 904
            |....:.::.|...|                       ||:...|....|..:.::..:||   |
Zfish   719 PCICEVIRSEKEQAKCPLCRAQIKTKELVEYPGEQAETRSDTGENWRSSSKALALMSNLLK---L 780

  Fly   905 KSSDD--KAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRN-NQKRVLLL 966
            ::.|.  |::||||:|..||:|...|.:.|.:...|:|::..:.|...:.:|.|.. ....::||
Zfish   781 RNEDPTVKSMVVSQFTGFLDVLEVALREYGFSFTRLDGSLIQRARAKAIEDFQDSTPGSPTIMLL 845

  Fly   967 SLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQD 1031
            ||.||||||||..|:.:.::|..|||..|.|..||.:|:||.::|:|.||:..|:||:.:..:|.
Zfish   846 SLKAGGVGLNLTAASQVFVMDPAWNPAAEDQCVDRCHRLGQSRDVVITKFIVKDSVEENMVKIQK 910

  Fly  1032 KKLDLADGVLTGAKVS---SKLTIDDLKGL 1058
            ||.:|.|... |.|.|   .:..|||::.|
Zfish   911 KKQELVDKAF-GVKNSQDAKQARIDDIRAL 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	SNF2_N	442..805	CDD:278600	134/475 (28%)
		DEXDc	459..634	CDD:238005	76/258 (29%)
		HELICc	885..1014	CDD:238034	46/131 (35%)
hltf	XP_005163433.1	HIRAN	59..144	CDD:214906	11/89 (12%)
		SNF2_N	229..662	CDD:278600	134/475 (28%)
		DEXDc	<418..528	CDD:238005	43/110 (39%)
		RING	696..741	CDD:238093	4/44 (9%)
		Helicase_C	767..885	CDD:278689	43/120 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2250
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950