Protein Alignment lds and chd1

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_009303375.1
• Gene: chd1 / 563236
• ZFINID: ZDB-GENE-030131-7120
• Length: 1778
• Species: Danio rerio
• Alignment Length: 1201
• Identity: 256/1201 - (21%)
• Similarity: 412/1201 - (34%)
• Gaps: 425/1201 - (35%)

  Fly    12 KEEDSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSETAESEKSDESD 76
            :.||..|:||| |.|      |.|...|.|...|.:|           .|.||.::.|.:|..||
Zfish     4 RSEDESVSNSS-GES------SNSDDESGSGSGSGSG-----------SSSSSSSSSSSQSGSSD 50

  Fly    77 NSQNSQESEDSEDDSVRPSARNTKRKPLGIPSDSEDEEDELEQRALSPSTRMSIT---------- 131
            :...|.....|:.||.:...:|             |::::::..|...|....:|
Zfish    51 SGSGSDSGSQSDSDSEKSKEKN-------------DQDNKIDGAAFWNSNPSILTVQRTAMLRKQ 102

  Fly   132 GVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVLDDSS 196
            .::.|.|....|....|||......|:                  .:|..|....:.|: .|..|
Zfish   103 QIQQQQLQQQSSSNTGSDEDSSSSDES------------------DDDSKSRSKGSGSD-SDSGS 148

  Fly   197 GSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLSQPTI 261
            ||.    |....     ||.:::|.:: |::|........||..|.:.|.|   :..:|...|
Zfish   149 GSG----SGSSD-----SSAEEEANSD-ESVSDYEPSHKVKSRKPSNKANA---RNGRNNKAP-- 198

  Fly   262 QAVLKQKTSP-------------AAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLF 313
                |:|.|.             |.|||....:...|      .|||::         :|::.|.
Zfish   199 ----KKKPSHSSSDDEDDYKKALAGPRRQATVNVSYK------EDEELK---------TDSDDLV 244

  Fly   314 EKVAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVP-AVRVV-------KPTLN--PP 368
            |.....:|.....   ..:||.|.:.|        |:.:..|. ||..|       .|..|  |.
Zfish   245 EVCGEDVPPPEED---EFETLERVMEM--------RIGRKGVTGAVTTVYAVEADGDPNANFDPN 298

  Fly   369 RAPS-----IDTLDWDELS---EAVNEIKPVYTGAQGMATFNNQKALTLESLK------------ 413
            |.|.     |...:|..:.   |....:|  ....:||...:|.|....|..|
Zfish   299 RQPGEVQYLIKWKNWSHIHNTWETEETLK--QQNVKGMKKLDNFKKKEQEKKKWLKAASPEDVEY 361

  Fly   414 ---------DLH-----------------------------------VSLED------------- 421
                     |||                                   .|.||
Zfish   362 FNCQQELMDDLHSQYQLVERIIGHSNQKSAAGYPDYLCKWQGLPYSECSWEDGALISKKFQKCID 426

  Fly   422 ----------LPGPE--VLAEDP--VGLK----------VSLMNHQKHALAWM--SWRERKLPRG 460
                      :|..:  ||.:.|  |.:|          :.|.::|...|.||  ||     .:|
Zfish   427 EYMSRNQCKTIPSRDCKVLKQRPRFVPMKKQPHYIGGEGLELRDYQLDGLNWMAHSW-----CKG 486

  Fly   461 G--ILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTR 523
            .  ||||:||||||:..||.:....:..::
Zfish   487 NSCILADEMGLGKTIQTISFLNYLFHEHQL----------------------------------- 516

  Fly   524 RGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNR-----------ETKGKYLRDYDIVVT 577
            .|..|:|.|.|.|..|:.|::.......:.|.:...|:|           :||...|   :|::|
Zfish   517 YGPFLLVVPLSTLTSWQREIQLWAPLMNVVVYLGDINSRNMIRTHEWMHPQTKRLKL---NILLT 578

  Fly   578 TYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDV 642
            ||:|:.::...|.   .|.|..|.:||||.::|..|.....:.:.:..:|..:||||:||...::
Zfish   579 TYEILLKDKSFLG---NVSWAFIGVDEAHRLKNDDSLLYKTMIEFKSNHRLLITGTPLQNSLKEL 640

  Fly   643 YALLKFLRCSPFDDLHTWKKWIDNKSAG---GQNRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKE 704
            ::||.|:....|   |:|:.:.:....|   |...|:..::..:|||.|..::     .|||.|.
Zfish   641 WSLLHFIMPEKF---HSWEMFEEEHGKGRDSGYTSLHKELEPFLLRRVKKDVE-----KSLPAKV 697

  Fly   705 LRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKM 769
            .:::.:.:...:...|:.::|.                   ||:
Zfish   698 EQILRVEMSAVQKQYYKWILTR-------------------NYK--------------------- 722

  Fly   770 HEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQ 834
                |...|:|.....  .|.:::.|::.|.|..||..
Zfish   723 ----ALSKGTKGSTSG--FLNIMMELKKCCNHCYLIKP--------------------------- 754

  Fly   835 LNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQIL 899
                                        ||:       .....|...:.:|.|.|.|:.::.::|
Zfish   755 ----------------------------PDD-------NEFYNRQEGLQHLVRSSGKLILLDKLL 784

  Fly   900 KTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVL 964
            ..  ||....:.::.||...:||||.::|.........|:|:|..:.|:..::.||...::....
Zfish   785 VR--LKERGHRVLIFSQMVRMLDILAEYLKYRQFLFQRLDGSIKGEMRKQALDHFNADGSEDFCF 847

  Fly   965 LLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGL 1029
            |||..|||:|:||..|:.:::.|..||||.:.|||.|.:|:||||.|.||:.:...:||:.|...
Zfish   848 LLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGSVEEEIIER 912

  Fly  1030 QDKKLDLADGVL------------TGAKVSS 1048
            ..||:.|...|:            |||..||
Zfish   913 AKKKMVLDHLVIQRMDTTGKTVLHTGAAPSS 943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	185/882 (21%)
		DEXHc_TTF2	439..686	CDD:350830	66/264 (25%)
chd1	XP_009303375.1	CD1_tandem_CHD1-2_like	258..340	CDD:349313	20/91 (22%)
		CD2_tandem_CHD1-2_like	375..431	CDD:349308	3/55 (5%)
		PLN03142	457..>987	CDD:215601	148/651 (23%)
		CDH1_2_SANT_HL1	1112..1199	CDD:477096
		DUF4208	1481..1571	CDD:464035
		U2AF_lg	1661..>1751	CDD:273727