Protein Alignment lds and CHD7

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_011515855.1
• Gene: CHD7 / 55636
• HGNCID: 20626
• Length: 3027
• Species: Homo sapiens
• Alignment Length: 1094
• Identity: 237/1094 - (21%)
• Similarity: 398/1094 - (36%)
• Gaps: 350/1094 - (31%)

  Fly    28 KSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSETAESEKSDESDNSQNSQESEDSEDDSV 92
            |..:..|:.::.|..:...|.....:.:|.::.|.....:|:....:..|...::.||:|:.|..
Human   666 KEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTEGSENSDLDKT 730

  Fly    93 RPSARNTKRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEGPTE 157
            .|.:          |...|||:..:::|..|...:        :....:|.|.:.|||      |
Human   731 PPPS----------PPPEEDEDPGVQKRRSSRQVK--------RKRYTEDLEFKISDE------E 771

  Fly   158 APTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVLDDSSGSDVLILSNKETPIEILSSTDDDATT 222
            |..|:|                                        :.:::|    |:|......
Human   772 ADDADA----------------------------------------AGRDSP----SNTSQSEQQ 792

  Fly   223 NKENMSGPPFER--PSKSLSPRSSAGASV------VKTSKNLSQ-----PTIQAVLKQKTSPAAP 274
            ...:..||..|:  .|:|:..:..:|..|      || .||.|.     .:|:.:.|.|......
Human   793 ESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVK-YKNFSYLHCQWASIEDLEKDKRIQQKI 856

  Fly   275 RRSRIKSEDQKVVSQVVYDE-------EMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRID 332
            :|.:.|....|.:|: :.||       |:.::.:......|..   |.|.|.|. |...:.....
Human   857 KRFKAKQGQNKFLSE-IEDELFNPDYVEVDRIMDFARSTDDRG---EPVTHYLV-KWCSLPYEDS 916

  Fly   333 TLRRELAMDEQWISALRVQQSNVPAV-RVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQ 396
            |..|...:|:..|.......|..|.. ||.:|..:          ||.: ||:..|.|
Human   917 TWERRQDIDQAKIEEFEKLMSREPETERVERPPAD----------DWKK-SESSREYK------- 963

  Fly   397 GMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWM--SWRERKLPR 459
                 ||.|                                 |..:|...:.|:  :|...   |
Human   964 -----NNNK---------------------------------LREYQLEGVNWLLFNWYNM---R 987

  Fly   460 GGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRR 524
            ..||||:||||||:..|:.:...                                ..||    ..
Human   988 NCILADEMGLGKTIQSITFLYEI--------------------------------YLKG----IH 1016

  Fly   525 GGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGN------------------NRETKGKYLRD 571
            |..||:.|.|.:..||.|..:..   :|.|.|:||:                  .|..||.|  .
Human  1017 GPFLVIAPLSTIPNWEREFRTWT---ELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSY--K 1076

  Fly   572 YDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVV--RNHKSQSSLAVCDLRGKYRWALTGTP 634
            :..::||::::..:...|.   .:.||.:::||||.:  ||.|....|.:.||  :::..|||||
Human  1077 FHAIITTFEMILTDCPELR---NIPWRCVVIDEAHRLKNRNCKLLEGLKMMDL--EHKVLLTGTP 1136

  Fly   635 IQNKELDVYALLKFLRCSPFDDLHTW-KKWIDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGKLN 698
            :||...::::||.||..|.|....|: :::.|.|:.....:|..::|.:||||.|..::     .
Human  1137 LQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVE-----K 1196

  Fly   699 SLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPN 763
            :|..||..:||:.|...:...|:.::                 |.:|.:.|...    .|...||
Human  1197 NLAPKEETIIEVELTNIQKKYYRAIL-----------------EKNFTFLSKGG----GQANVPN 1240

  Fly   764 GAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGD--HSSDSDT 826
                                    :|..::.||:.|.||.||    :|.|.:.:.:  .:.::::
Human  1241 ------------------------LLNTMMELRKCCNHPYLI----NGAEEKILEEFKETHNAES 1277

  Fly   827 PEIDLLAQL---NKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRP 888
            |:..|.|.:   .||.:.|                 .|||.
Human  1278 PDFQLQAMIQAAGKLVLID-----------------KLLPK------------------------ 1301

  Fly   889 SSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNE 953
                           ||:...:.::.||....||||.|:|.:.......::|.:....||..::.
Human  1302 ---------------LKAGGHRVLIFSQMVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAIDR 1351

  Fly   954 FNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMC 1018
            |:..::.:.|.||...|||:|:||..|:..::.|..||||.:.|||.|.:|:||.|:|.||:.:.
Human  1352 FSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLIT 1416

  Fly  1019 VDTVEQRIKGLQDKKLDLADGVL----------TGAKVSSKLTIDDL--KGLFG 1060
            .::.|:.:......||.|...||          .|.:..||..|:||  ||.:|
Human  1417 RNSYEREMFDKASLKLGLDKAVLQSMSGRENATNGVQQLSKKEIEDLLRKGAYG 1470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	177/789 (22%)
		DEXHc_TTF2	439..686	CDD:350830	70/269 (26%)
CHD7	XP_011515855.1	Atrophin-1	197..>578	CDD:460830
		CD1_tandem_CHD5-9_like	796..861	CDD:349315	16/65 (25%)
		CD2_tandem_CHD5-9_like	879..936	CDD:349310	11/60 (18%)
		PLN03142	967..>1566	CDD:215601	161/696 (23%)
		BRK	2593..2634	CDD:462196
		BRK	2672..2716	CDD:197800