DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment lds and hells

DIOPT Version :10

Sequence 1:NP_524850.2 Gene:lds / 45894 FlyBaseID:FBgn0002542 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_001032178.1 Gene:hells / 553328 ZFINID:ZDB-GENE-030131-9923 Length:853 Species:Danio rerio


Alignment Length:936 Identity:223/936 - (23%)
Similarity:371/936 - (39%) Gaps:256/936 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   227 MSG----------PPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKS 281
            |||          |...:|::|..|.   |.::.:|:...|:.....:.|:...    ....::.
Zfish     1 MSGIVKEETRSISPHCPKPNESEEPE---GTTIEETTMEKSKHEEMVITKEMEE----EEKNLEE 58

  Fly   282 EDQKVVSQVVYD---------EEMR----------------KLAEKRVQVSDAEKL----FEKVA 317
            |.:|...:::.:         :|||                .|..|..|....|||    .||.|
Zfish    59 EGEKKEREMMEEARQSRGNDSQEMRFKRLQHLLEKSNIYSKFLLTKMEQQQQEEKLKKERLEKKA 123

  Fly   318 HKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSI--DTLDWDE 380
            ..|..|||. .|.:...|::...::..|:.:..::..:...:  ||.:......|:  :..|.::
Zfish   124 AVLKQKGSD-KKTVKVERKKRGREDYKIADVMTKEEIMSKAK--KPKMEEEAQASVKLEAEDIEK 185

  Fly   381 LSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMN-HQK 444
            ||:..::||    |........|.|.: |:..:.::       |..|.|:.|......:|. :|.
Zfish   186 LSDTNSDIK----GRLSETLRENSKQM-LDPERTVN-------GQPVPAQQPQLFTGGVMRWYQV 238

  Fly   445 HALAW--MSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKK 507
            ..:.|  |.| |..:  .|||||:||||||:..|:.:..      |.|                 
Zfish   239 EGIEWLRMLW-ENGI--NGILADEMGLGKTIQCIAHIAM------MVE----------------- 277

  Fly   508 RKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRET-------- 564
             |.|.            |..|||.|.|.|..|.||.  |....:::|.::||..:|.        
Zfish   278 -KKVL------------GPFLVVAPLSTLPNWISEF--KRFTPEVSVLLYHGPQKERLDLVKKIR 327

  Fly   565 --KGKYLRDYDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYR 627
              :|. ||...:|||:::|..|:.|.|..   ..|..:|:||.|.::|...:....:..|....:
Zfish   328 QHQGS-LRMCPVVVTSFEIAMRDRKFLQR---FHWNYLIVDEGHRIKNLNCRLVQELKMLPTDNK 388

  Fly   628 WALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGG-----------QN---RLNLL 678
            ..|||||:||...::::||.||....||||.:::.|.|..:...           ||   .|:|:
Zfish   389 LLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDISTITSDAENIVANEREQNILHMLHLI 453

  Fly   679 MKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERET 743
            :...:|||    |:||..|...|.||: ::...|..::...|..::  ::|: |:.|.|..:...
Zfish   454 LTPFLLRR----LKSDVTLEVPPKKEI-VVYAPLTNKQEAFYMAIV--NKTI-AKLLGQEKDESA 510

  Fly   744 D----------------FNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGS------------K 780
            .                .||    .:|..:.:||......|:.::....|.|            :
Zfish   511 PAPLTPSGRPKRRSRKVVNY----TEPNTDSMKDLEKYLEKVQQELDSQASSTPVVNVFMPVDAQ 571

  Fly   781 KEVKSHDILVLLLRLRQICC-HPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTS 844
            ..:|..:||:||.|    || |..||:..||    .|.||...|.     .|:....|..|.|. 
Zfish   572 VNLKLQNILMLLKR----CCNHAYLIEYPLD----PTTGDFKIDE-----QLVEASGKFLILDR- 622

  Fly   845 TDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDD 909
                            :||:                                       ||....
Zfish   623 ----------------MLPE---------------------------------------LKKRGH 632

  Fly   910 KAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVG 974
            |.::.||.||:||||.|:....|.....|:|::...:|.:.:.:|:. :.:..:.|||..|||:|
Zfish   633 KVLIFSQMTSILDILMDYCYLRGYEYSRLDGSMSYADRDENMKKFSS-DPEVFLFLLSTRAGGLG 696

  Fly   975 LNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADG 1039
            :||..|:.:::.|..||||.:.|||||.:|:||.|.|::::.:..:|::::|......|..|...
Zfish   697 INLTSADTVIIFDSDWNPQADLQAQDRCHRIGQTKPVVVHRLITANTIDEKILERASAKRKLEKM 761

  Fly  1040 VL-----TGAKVSSK-----LTIDDL 1055
            |:     .|:|...|     |.:|:|
Zfish   762 VIHKNKFKGSKAELKQSKSCLDVDEL 787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ldsNP_524850.2 HepA 287..1041 CDD:440319 203/840 (24%)
DEXHc_TTF2 439..686 CDD:350830 76/273 (28%)
hellsNP_001032178.1 nuclear localization signal 140..145 1/4 (25%)
PLN03142 224..>813 CDD:215601 176/691 (25%)
DEXHc_HELLS_SMARCA6 230..463 CDD:350767 78/281 (28%)
conserved domain I 241..265 13/26 (50%)
conserved domain Ia 285..294 5/8 (63%)
conserved domain II 353..371 6/20 (30%)
leucine zipper motif 389..410 9/20 (45%)
conserved domain III 390..397 5/6 (83%)
conserved domain IV 456..466 5/13 (38%)
Shugoshin_C 518..>534 CDD:462207 2/19 (11%)
conserved domain IVa 580..592 7/15 (47%)
conserved domain IVb 631..642 3/10 (30%)
conserved domain V 688..701 8/12 (67%)
conserved domain VI 719..729 6/9 (67%)

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