Protein Alignment lds and ERCC6L

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_060139.2
• Gene: ERCC6L / 54821
• HGNCID: 20794
• Length: 1250
• Species: Homo sapiens
• Alignment Length: 756
• Identity: 179/756 - (23%)
• Similarity: 299/756 - (39%)
• Gaps: 233/756 - (30%)

  Fly   377 DWDELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDL-------------PGPEVL 428
            |.:|..:..|..|.:         |.|:|.|:  .::.:..:||:|             .|..:.
Human    36 DLEEAFKLFNLAKDI---------FPNEKVLS--RIQKIQEALEELAEQGDDEFTDVCNSGLLLY 89

  Fly   429 AEDPVGLKVSLMNHQKHALAWMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKD 493
            .|    |...|..|||..:|::....|...:|||||||||||||:.:|:.:....:...::.
Human    90 RE----LHNQLFEHQKEGIAFLYSLYRDGRKGGILADDMGLGKTVQIIAFLSGMFDASLVNH--- 147

  Fly   494 ESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHH 558
                                             .|::.|.:|:..|..|........:  |...|
Human   148 ---------------------------------VLLIMPTNLINTWVKEFIKWTPGMR--VKTFH 177

  Fly   559 GNNRETKGKYLRDYD----IVVTTYQIVAREHKSLSAVFGVK--WRRIILDEAHVVRNHKSQSSL 617
            |.:::.:.:.|....    :::||||::....:.||:..|.:  |..:||||||.::...::|::
Human   178 GPSKDERTRNLNRIQQRNGVIITTYQMLINNWQQLSSFRGQEFVWDYVILDEAHKIKTSSTKSAI 242

  Fly   618 AVCDLRGKYRWALTGTPIQNKELDVYALLKFLRC--SPFDDLHTWKKWIDN-------------- 666
            ....:....|..||||||||...::::|..| .|  |....|.|:|...:|
Human   243 CARAIPASNRLLLTGTPIQNNLQELWSLFDF-ACQGSLLGTLKTFKMEYENPITRAREKDATPGE 306

  Fly   667 KSAGGQNRLNL--LMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLD------------KEEM 717
            |:.|.:...||  ::|...|||||..:|.  |.:|  |.|.||.|.:.|            |.::
Human   307 KALGFKISENLMAIIKPYFLRRTKEDVQK--KKSS--NPEARLNEKNPDVDAICEMPSLSRKNDL 367

  Fly   718 NVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKE 782
            .::..::.....::.:|:            ..|..|....:.:.|
Human   368 IIWIRLVPLQEEIYRKFV------------SLDHIKELLMETRSP-------------------- 400

  Fly   783 VKSHDILVLLLRLRQICCHPGLIDAML------------DGEESQTMGDHSSDSDTPEIDLLAQL 835
                  |..|..|:::|.||.|:.|..            ||.|.:         |:|::|.:.|
Human   401 ------LAELGVLKKLCDHPRLLSARACCLLNLGTFSAQDGNEGE---------DSPDVDHIDQ- 449

  Fly   836 NKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILK 900
                :||.:                                        |...|.|:..::.:||
Human   450 ----VTDDT----------------------------------------LMEESGKMIFLMDLLK 470

  Fly   901 TSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIP-VKNRQDIVNEFNDRNNQKRVL 964
            .  |:....:.:|.||...:|:|:...|......||.::||:. :..|:..:|.| .:|....|.
Human   471 R--LRDEGHQTLVFSQSRQILNIIERLLKNRHFKTLRIDGTVTHLLEREKRINLF-QQNKDYSVF 532

  Fly   965 LLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGL 1029
            ||:...|||||.|..|..:::.|..|||..:|||.||:||:|||:||::|:.:...|||::|...
Human   533 LLTTQVGGVGLTLTAATRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRR 597

  Fly  1030 QDKKLDLADGVL---TGAKVS-----SK------LTIDDLK 1056
            |..|    |.::   ||.|.:     ||      .||:||:
Human   598 QVFK----DSLIRQTTGEKKNPFRYFSKQELRELFTIEDLQ 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	170/725 (23%)
		DEXHc_TTF2	439..686	CDD:350830	67/270 (25%)
ERCC6L	NP_060139.2	TPR 1	21..54		5/26 (19%)
		HepA	<90..610	CDD:440319	158/665 (24%)
		DEXHc_ERCC6L	96..328	CDD:350759	67/270 (25%)
		DEAH box	228..231		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	735..768
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	926..946
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1061..1092
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1110..1199
		TPR 2	1200..1233