DRSC/TRiP Functional Genomics Resources

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Protein Alignment lds and INO80

DIOPT Version :10

Sequence 1:NP_524850.2 Gene:lds / 45894 FlyBaseID:FBgn0002542 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_060023.1 Gene:INO80 / 54617 HGNCID:26956 Length:1556 Species:Homo sapiens


Alignment Length:1345 Identity:287/1345 - (21%)
Similarity:503/1345 - (37%) Gaps:411/1345 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 NSEYYSDKEEDSVVNNSSLGRSRKSSRLSKS-------------SRLSKSSRPSSAGVVIDETQS 56
            |....||..||.:.:::.|        |.:|             |.|.::|...|:|::...:.:
Human    43 NRNISSDDSEDGLDDSNPL--------LPQSGDPLIQVKEEPPNSLLGETSGAGSSGMLNTYSLN 99

  Fly    57 EEEESQS----------SETAESEK-------SDESDNSQNSQESEDSED-----DSVRPSARNT 99
            ...:|:|          |:..:|.|       ||||..:.:..|.:|.|:     :.:....|..
Human   100 GVLQSESKCDKGNLYNFSKLKKSRKWLKSILLSDESSEADSQSEDDDEEELNLSREELHNMLRLH 164

  Fly   100 KRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAV 164
            |.|.|.....|:|:  ||:|      .:....|:    ||..|...|....:. ||.:....|  
Human   165 KYKKLHQNKYSKDK--ELQQ------YQYYSAGL----LSTYDPFYEQQRHLL-GPKKKKFKE-- 214

  Fly   165 VPRYTTQFAGNIQNDLHSTIGAADSEVLDDSSGSDVLILSNKETP------IEILSSTDDDAT-- 221
                        :..|.:.:.....:...|..      ||::|:|      .::.:....||.  
Human   215 ------------EKKLKAKLKKVKKKRRRDEE------LSSEESPRRHHHQTKVFAKFSHDAPPP 261

  Fly   222 -TNKENMSGPPF--------------ERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLK----- 266
             |.|:::|....              |.| |:...::||....:..|:.|:...::.|.:     
Human   262 GTKKKHLSIEQLNARRRKVWLSIVKKELP-KANKQKASARNLFLTNSRKLAHQCMKEVRRAALQA 325

  Fly   267 ----QKTSPAAPR----------------RSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEK 311
                ::|.|.|.|                :...|..:::.:.|...|||||:...::.:::....
Human   326 QKNCKETLPRARRLTKEMLLYWKKYEKVEKEHRKRAEKEALEQRKLDEEMREAKRQQRKLNFLIT 390

  Fly   312 LFEKVAH---KLPDKG-----SQIMKRIDTLRRELAMDEQWISALRVQQ----SNVPAVRVVKPT 364
            ..|..||   :..|.|     .:|:::::....:..:|......:.:.|    ||....:.:|..
Human   391 QTELYAHFMSRKRDMGHDGIQEEILRKLEDSSTQRQIDIGGGVVVNITQEDYDSNHFKAQALKNA 455

  Fly   365 LNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMAT-FNNQKALTLESLKDLHVSLEDLPGPEVL 428
            .|........|..:||  :|..........|....| |....:|...|::    :.||:|.|.: 
Human   456 ENAYHIHQARTRSFDE--DAKESRAAALRAANKSGTGFGESYSLANPSIR----AGEDIPQPTI- 513

  Fly   429 AEDPVGLKVSLMNHQKHALAWMSWRERKLPRG--GILADDMGLGKTLTMISSVLACKNGQEMSEG 491
                  ....|..:|   |..|:|......:|  |||||:||||||:..| ::||     .::| 
Human   514 ------FNGKLKGYQ---LKGMNWLANLYEQGINGILADEMGLGKTVQSI-ALLA-----HLAE- 562

  Fly   492 KDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCV 556
                            |:::  |          |..|::.|||.|..|..|....|  .|..|..
Human   563 ----------------RENI--W----------GPFLIISPASTLNNWHQEFTRFV--PKFKVLP 597

  Fly   557 HHGNNRE---------TKGKYLRD--YDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRN 610
            :.||..:         .|..|.:|  :.:|:|:||:|.::.|....   |||:.::||||..:::
Human   598 YWGNPHDRKVIRRFWSQKTLYTQDAPFHVVITSYQLVVQDVKYFQR---VKWQYMVLDEAQALKS 659

  Fly   611 HKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWI--------DNK 667
            ..|.....:...:.:.|..||||||||...:::|||.|:..:.||....:.:|.        :||
Human   660 SSSVRWKILLQFQCRNRLLLTGTPIQNTMAELWALLHFIMPTLFDSHEEFNEWFSKDIESHAENK 724

  Fly   668 SAGGQN---RLNLLMKSLMLRRTK----------------AQLQSDGKL--NSLPNK----ELRL 707
            ||..:|   ||::::|..||||.|                .||.|..||  .:|.||    :|..
Human   725 SAIDENQLSRLHMILKPFMLRRIKKDVENELSDKIEILMYCQLTSRQKLLYQALKNKISIEDLLQ 789

  Fly   708 IEISLDKEEMNVYQTVMTYSRTLFAQF--------LHQRAERETDFN------------YRSDAN 752
            ..:...::..|...::|    .|..||        |.:|.|..:.|:            ||....
Human   790 SSMGSTQQAQNTTSSLM----NLVMQFRKVCNHPELFERQETWSPFHISLKPYHISKFIYRHGQI 850

  Fly   753 KPTYNQIKD----------PN-------------------------------------------- 763
            : .:|..:|          |:                                            
Human   851 R-VFNHSRDRWLRVLSPFAPDYIQRSLFHRKGINEESCFSFLRFIDISPAEMANLMLQGLLARWL 914

  Fly   764 ------GAYYKMHEKFARMAGS------KKEVKSHDILV---LLLRLRQICCHPGLIDAMLDGEE 813
                  .|.|::|:  .|..|:      ::.:::.|.|:   ..|....:|..| |:.:::....
Human   915 ALFLSLKASYRLHQ--LRSWGAPEGESHQRYLRNKDFLLGVNFPLSFPNLCSCP-LLKSLVFSSH 976

  Fly   814 SQTMGDHSSD-----------------SDTPEIDLLAQLNKLAI------TDTSTDGQQSVANAG 855
            .:.:..:|..                 ::.|....:|.....|:      .|.|.:.::.|...|
Human   977 CKAVSGYSDQVVHQRRSATSSLRRCLLTELPSFLCVASPRVTAVPLDSYCNDRSAEYERRVLKEG 1041

  Fly   856 D---------DGPPLLPDEARIAKASKNLLKRS----NPVFNLH--RPSSKINMV---------- 895
            .         :|.|.|        |:..|.:||    .|...|.  ||.:..:.:          
Human  1042 GSLAAKQCLLNGAPEL--------AADWLNRRSQFFPEPAGGLWSIRPQNGWSFIRIPGKESLIT 1098

  Fly   896 -------IQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNE 953
                   :.:|.|. |||...:.::.||.|.::|:|.:::.......:.|:|:..:..|:|:|.:
Human  1099 DSGKLYALDVLLTR-LKSQGHRVLIYSQMTRMIDLLEEYMVYRKHTYMRLDGSSKISERRDMVAD 1162

  Fly   954 FNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMC 1018
            |.:||: ..|.|||..|||:|:||..|:.::..|..|||.::.||.||.:|:||.|.|.:|:.:|
Human  1163 FQNRND-IFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLIC 1226

  Fly  1019 VDTVEQRIKGLQDKKLDLADGVLTGA---------KVSSKLTIDD 1054
            ..|:|:||.....:|.::...|::|.         |....|.:||
Human  1227 KGTIEERILQRAKEKSEIQRMVISGGNFKPDTLKPKEVVSLLLDD 1271

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ldsNP_524850.2 HepA 287..1041 CDD:440319 215/956 (22%)
DEXHc_TTF2 439..686 CDD:350830 79/270 (29%)
INO80NP_060023.1 Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D. /evidence=ECO:0000269|PubMed:21303910 1..266 51/263 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..87 10/48 (21%)
Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1. /evidence=ECO:0000269|PubMed:21303910 212..526 59/350 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 219..249 5/35 (14%)
HepA 298..>830 CDD:440319 140/591 (24%)
DEXQc_INO80 518..746 CDD:350760 79/270 (29%)
Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2. /evidence=ECO:0000269|PubMed:21303910 521..1556 189/812 (23%)
SF2_C_SNF 1090..1225 CDD:350180 43/136 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1283..1316
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1388..1408
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1420..1461
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1499..1556
Blue background indicates that the domain is not in the aligned region.

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