DRSC/TRiP Functional Genomics Resources

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Protein Alignment lds and ATRX

DIOPT Version :10

Sequence 1:NP_524850.2 Gene:lds / 45894 FlyBaseID:FBgn0002542 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_000480.3 Gene:ATRX / 546 HGNCID:886 Length:2492 Species:Homo sapiens


Alignment Length:1272 Identity:261/1272 - (20%)
Similarity:463/1272 - (36%) Gaps:385/1272 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSENSEYYSDKEEDSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEES----- 61
            ||.::|.||.||:..   |||   .::..|:....|.:.||:.::..:....:.|:.|||     
Human  1108 SSSDTEKYSMKEDGC---NSS---DKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNK 1166

  Fly    62 -----------------------------QSSETAESEKSDESDNSQNSQESEDSEDDSVRPSAR 97
                                         :.::...|..||..|:.|||.....|::..::|...
Human  1167 KKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTE 1231

  Fly    98 N------------------TKRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSE 144
            |                  :|..|:.:  |.:|::::.|.|.   :.:|.:..::....||:|..
Human  1232 NLVLSSHTGFCQSSGDEALSKSVPVTV--DDDDDDNDPENRI---AKKMLLEEIKANLSSDEDGS 1291

  Fly   145 IEYSDEVQEG-----------------------PTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGA 186
            .:  ||.:||                       .:::.:.|:..|||..:.       |...:..
Human  1292 SD--DEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRL-------LRHKLTV 1347

  Fly   187 ADSEVLDDSSGSDVLILSNKETPIE----------ILSSTDDDATTNKENMSGPPFERPSKSLSP 241
            :|.|     ||.:     .|..|.|          .:||.|.:.:..:|:..............|
Human  1348 SDGE-----SGEE-----KKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRP 1402

  Fly   242 RSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIK-----SEDQKVVSQVVYDEEMRKLAE 301
            |:       :::|.......|...|||     .:|.|||     |.:.|..|:  .:||.::..|
Human  1403 RT-------RSAKKAELEENQRSYKQK-----KKRRRIKVQEDSSSENKSNSE--EEEEEKEEEE 1453

  Fly   302 KRVQVSDAEKLFEKVAHKLPDKGSQIMKRI---DTLRREL--AMDEQWISALRV-----QQSNVP 356
            :..:..:.|:..|....|.|.||.:.:::|   |.||.|.  |:.|:.....|:     ::..:.
Human  1454 EEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLR 1518

  Fly   357 AVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLED 421
            .|..::.. :|.:.|....|..||..|                        |.|.|..:|.:   
Human  1519 EVIEIEDA-SPTKCPITTKLVLDEDEE------------------------TKEPLVQVHRN--- 1555

  Fly   422 LPGPEVLAEDPVGLKVSLMNHQKHALAWMSW--------RERKLPRGG-ILADDMGLGKTLTMIS 477
                         :.:.|..||...:.:| |        :.:|.|..| |||..|||||||.::|
Human  1556 -------------MVIKLKPHQVDGVQFM-WDCCCESVKKTKKSPGSGCILAHCMGLGKTLQVVS 1606

  Fly   478 ---SVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQW 539
               :||.|                |..|...                     .|||||.:....|
Human  1607 FLHTVLLC----------------DKLDFST---------------------ALVVCPLNTALNW 1634

  Fly   540 ESEV----ESKVSRQKLTVCVHHGNNRETKGKYL-----RDYDIVVTTYQIVAREHKSLSAVFGV 595
            .:|.    |.....:||.|.......|..:..|:     .|..:::..|::    :::|:....|
Human  1635 MNEFEKWQEGLKDDEKLEVSELATVKRPQERSYMLQRWQEDGGVMIIGYEM----YRNLAQGRNV 1695

  Fly   596 KWRR----------------IILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYA 644
            |.|:                ::.||.|:::|..|..|.|:..:|.:.|..|||||:||..::.:.
Human  1696 KSRKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHC 1760

  Fly   645 LLKFLRCSPFDDLHTWKKWIDNKSAGGQ-------------NRLNLLMKSL---MLRRTKAQLQS 693
            ::.|::.:....:..::....|....||             .|.::|.:.|   :.|:....|  
Human  1761 MVNFIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTAL-- 1823

  Fly   694 DGKLNSLPNKELRLIEISLDKEEMNVYQTVMTY---------------SRTLFAQFLHQRAERE- 742
               ...||.|...::.:.:...:..:||..:.:               ...||..|  |...|. 
Human  1824 ---TKFLPPKHEYVLAVRMTSIQCKLYQYYLDHLTGVGNNSEGGRGKAGAKLFQDF--QMLSRIW 1883

  Fly   743 -----TDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGS-----KKEVKSHDILVLLLRLRQ 797
                 ...:|.|..||..:::  |....:.........|:.|     ||:.|..           
Human  1884 THPWCLQLDYISKENKGYFDE--DSMDEFIASDSDETSMSLSSDDYTKKKKKGK----------- 1935

  Fly   798 ICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLL 862
                        .|::..:.....||:|...|       |:..:.:...|:.:|...|::....|
Human  1936 ------------KGKKDSSSSGSGSDNDVEVI-------KVWNSRSRGGGEGNVDETGNNPSVSL 1981

  Fly   863 PDEARIAKASKNLLKRSNPVFNLHRP------------SSKINMVIQILKTSILKSSDDKAIVVS 915
            ..|...|.:|.|   .|:|..:.::.            |.|:.::.:||:  :.:...||.:|.|
Human  1982 KLEESKATSSSN---PSSPAPDWYKDFVTDADAEVLEHSGKMVLLFEILR--MAEEIGDKVLVFS 2041

  Fly   916 QWTSVLDILRDHL---------SKD-------------GVATLSLNGTIPVKNRQDIVNEFNDRN 958
            |....||::.|.|         .||             .:....|:|:...::|:....||||..
Human  2042 QSLISLDLIEDFLELASREKTEDKDKPLIYKGEGKWLRNIDYYRLDGSTTAQSRKKWAEEFNDET 2106

  Fly   959 NQK-RVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTV 1022
            |.: |:.::|..||.:|:||:.||.:::.|..|||..:.|:..|:||.||.|.|.:|:|:...|:
Human  2107 NVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTM 2171

  Fly  1023 EQRIKGLQDKKLDLADGVLTGAKVSSKLTIDDLKGLF 1059
            |.:|...|..|..|:..|:...:|....|:::|..|:
Human  2172 EDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELY 2208

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ldsNP_524850.2 HepA 287..1041 CDD:440319 185/877 (21%)
DEXHc_TTF2 439..686 CDD:350830 66/299 (22%)
ATRXNP_000480.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..147
ADDz_ATRX 167..270 CDD:277252
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 445..516
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 535..576
PxVxL motif 581..594
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 593..616
PTZ00108 <642..857 CDD:240271
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 649..956
PTZ00121 <791..1438 CDD:173412 70/371 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 968..1479 81/414 (20%)
Interaction with DAXX 1189..1326 24/143 (17%)
HepA <1543..2191 CDD:440319 162/773 (21%)
DEXHc_ATRX 1560..1803 CDD:350826 63/284 (22%)
DEGH box 1719..1722 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1913..2000 21/119 (18%)
Interaction with MECP2. /evidence=ECO:0000269|PubMed:17296936 2010..2280 57/201 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2462..2492
Blue background indicates that the domain is not in the aligned region.

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