Protein Alignment lds and XNP

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Alignment Length: 1256
• Identity: 278/1256 - (22%)
• Similarity: 460/1256 - (36%)
• Gaps: 397/1256 - (31%)

  Fly    14 EDSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEES-QSSETAESEKSDESDN 77
            :||  |:||:.| |:|:..|||:..|:||.|.|     :..||...:: ::|..|....|.:||.
  Fly    20 DDS--NSSSVSR-RESATESKSASESESSPPRS-----NTKQSRTHKNVKASGKATVSSSSDSDQ 76

  Fly    78 SQNSQESEDSEDDSV-------------------RPSARNTKRKPLGIPSDSEDEEDELEQRALS 123
            :..:..:.|.|.:.|                   ||| |.:::|.:.| :||.|||.....:.:.
  Fly    77 AVANSSANDEEKEPVCKIRIVPLEKLLASPKTKERPS-RGSQQKNVTI-NDSSDEEPLKGSKLVL 139

  Fly   124 PSTRMSITGVRPQDLSDDDSEIEYSDEVQEG-------PTEA-----------PTAEAVVPRY-- 168
            |:.:.........:|||.    |..||.:|.       |.||           .:.|::..|.
  Fly   140 PARKSRNKNASIIELSDS----EEVDEEEESLLVAIPLPKEAQQTKPEKNSSKASKESIEKRQKA 200

  Fly   169 ----TTQFAGNIQNDLHSTIGAADSEVLDDSSGS----------------DVLILSNK--ETPIE 211
                ||..|..|::...:..|:..||....:|.|                .|.:...|  :.|.:
  Fly   201 QKEATTSSARAIRSVNGTRRGSLSSERSSRASSSRAESPPRPKRCVVRLKRVSLPKTKPAQKPKK 265

  Fly   212 ILSSTDDDATTNKENMSGPPFERPSKSLSPRSS----AGASVVKTSKNLSQPTIQAVLKQKTSPA 272
            :.|.:::.|||:|::.     :|.|||.|...|    ..|...:..:..|....:.......|..
  Fly   266 MSSDSEEAATTSKKSR-----QRRSKSESEADSDYEAPAAEEEEEEERKSSGDEEEAANSSDSEV 325

  Fly   273 AP--RRSRIKSEDQKVVSQVVYDEEMRKLAEKRV-QVSDAEKLFEKVAHKLPDKGSQIMKRI--- 331
            .|  :|.|.|||..|..|....:|:.:|...||: :.|..|...:....|..:|...|.|.|
  Fly   326 MPQRKRRRKKSESDKGSSDFEPEEKQKKKGRKRIKKTSSGESDGDGDDDKQKNKRKHIRKIIKTK 390

  Fly   332 --DTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTG 394
              |...:|.|.:|                                    |:..:.:.:.:.:|
  Fly   391 DLDLTTKEAAKEE------------------------------------DDRRKRIEDRQKLY-- 417

  Fly   395 AQGMATFNNQKALTLESLKDLHVSLE-DLPGPEVLAEDPVGLKVSLMNHQKHALAWMSW------ 452
                    |:..:..||::...:.|: |....:.|.:...||...|..||...:.:| |
  Fly   418 --------NRIFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFM-WDACFET 473

  Fly   453 ---RERKLPRGGILADDMGLGKTL---TMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSV 511
               .:.|...|.|||..|||||||   |:..::|.
  Fly   474 LKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLV------------------------------ 508

  Fly   512 TGWKSKGRKDTRRGG---TLVVCPASLLRQWESEVES-------------KVSRQKLTVCVHHGN 560
                     :|||.|   .|::.|.|.:..|..|..|             .:||.|
  Fly   509 ---------NTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRNDIEVYDISRYK--------- 555

  Fly   561 NRETK-----------GKYLRDYDIVVTTYQIVAREHKSLSAVFGVKWRR--------------- 599
            ::.|:           |..:..||:    |:|:|.|...     |::.::
  Fly   556 DKPTRIFKLNEWFNEGGVCILGYDM----YRILANEKAK-----GLRKKQREQLMQALVDPGPDL 611

  Fly   600 IILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWI 664
            ::.||.|:::|.|:..|.||..:|.|.|..|||||:||...:.|.:::|::.:.   |.|:|:::
  Fly   612 VVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNL---LGTYKEYM 673

  Fly   665 D---NKSAGGQ----------------NRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEI 710
            :   |....||                :.|:.|::..:.||..:.|..     .||.|...::..
  Fly   674 NRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAP-----YLPPKHEYVVYT 733

  Fly   711 SLDKEEMNVYQTVMTYSR------------TLFAQFLHQRAERETDFNYR--SD---ANKPTYNQ 758
            :|.:.:..:|...||..|            .||..|...|.......|.|  ||   |.:...|.
  Fly   734 TLSELQQKLYGYYMTTHREQSGGDVVGKGARLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSND 798

  Fly   759 IKDPNG-------------------AYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGL 804
            ..|..|                   ..:|.....:.:|.|..:||...
  Fly   799 DSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRK----------------- 846

  Fly   805 IDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDE---A 866
                   ..:...|...||||   :::|..|.          |..||..  ||     |.|   .
  Fly   847 -------TRNGNAGGGDSDSD---LEMLGGLG----------GGSSVQK--DD-----PSEWWKP 884

  Fly   867 RIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLS-- 929
            .:.:...|         |:|. |.|:.:::::|:.  .::..||.:|.||....||::...||
  Fly   885 FVEERELN---------NVHH-SPKLLILLRLLQQ--CEAIGDKLLVFSQSLQSLDVIEHFLSLV 937

  Fly   930 --------------------KDGVATLSLNGTIPVKNRQDIVNEFNDRNN-QKRVLLLSLTAGGV 973
                                ..|.....|:|:..|:.|:.:..:||:..| :.|:.|:|..|||:
  Fly   938 DSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGL 1002

  Fly   974 GLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLAD 1038
            |:||:.||.:::.|:.|||..:.|:..|:||.||.|...||:.:.:.|:||::...|..|...|.
  Fly  1003 GINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAK 1067

  Fly  1039 GVLTGAKVSSKLTIDDLKGLF 1059
            .|:...::|......||..|:
  Fly  1068 RVIDEQQISRHYNQTDLMELY 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	190/895 (21%)
		DEXHc_TTF2	439..686	CDD:350830	69/319 (22%)
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	66/337 (20%)
		HepA	<382..1071	CDD:440319	182/856 (21%)
		DEXHc_ATRX	455..699	CDD:350826	67/304 (22%)