DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lds and Ino80

DIOPT Version :9

Sequence 1:	NP_524850.2	Gene:	lds / 45894	FlyBaseID:	FBgn0002542	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_732413.1	Gene:	Ino80 / 42314	FlyBaseID:	FBgn0086613	Length:	1638	Species:	Drosophila melanogaster

Alignment Length:	1403	Identity:	279/1403 - (19%)
Similarity:	491/1403 - (34%)	Gaps:	482/1403 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SDKEEDS--VV----------NNSSLG------RSRKSSRL--SKSSRLS-----------KSSR 43
            ||:|.|.  ||          ::|::|      .|::.|||  ||..|.|           .|.|
  Fly    48 SDEETDDEHVVKREHDVQDSDDSSTVGVVRMKQSSKRKSRLLASKEERQSVKAQLYNFNDLTSDR 112

  Fly    44 PSSAGVVIDETQSEEEESQSSETAES----------EKSDESDNSQNSQESED-----SEDD--- 90
            .....:::.:|:|::......|..:.          ::.:....:.|:|.:..     |..|
  Fly   113 EWLYDLLLSDTESDDPTITEDEYVQQLLREHVREQRQRKNYYKKAANAQYAYYGSGLLSNHDIFA 177

  Fly    91 -------SVRPSARNTKR--------------KP-------------LGIPSDSEDEEDELEQRA 121
                   .||...|.||:              ||             :|.|...|....||.:..
  Fly   178 ERQLATAGVRKRRRRTKQEILMARLAEAQAGPKPPKQRRRGRKKRDNMGSPESGEVPPSELGKYT 242

  Fly   122 LSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDL------ 180
            ...      |....:|..:|..|::|..|:.....:.|..|.:......:  |..:..:
  Fly   243 FGD------TLPNNEDDDEDGGEVDYKRELASLALDYPEEEEIEEEVDVE--GGTEGQVTKVRRK 299

  Fly   181 ---HSTIGAADSEVLDDSSGSDVLILSNKETP--IEILSSTDDDATTNKENMSGPPFERPSKSLS 240
               .:.:.|....:..        |:|.||:.  ..|.|:...:...|.:.::|    ..:|.:.
  Fly   300 RKNPAALAARRRRIWQ--------IMSKKESGRLQRIKSNNHKEMLANCKRVAG----MCAKVVR 352

  Fly   241 PRSSAGASVVK-TSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRV 304
            .|:.....::| |.....:.|.:.:...|......|..|.|.|.:.        ||.||...:.:
  Fly   353 QRAINSQRIMKETVWRAKRLTREMLAYWKRYERVERDQRRKQEREA--------EEQRKQDVELI 409

  Fly   305 QVSDAEKLF-------EKVAHKLPDK---GSQ-----IMKRID--TLRRELAMDEQWISALR-VQ 351
            :|...::..       |..||.:..|   ||:     |:.::|  |..|..|.|:.....:: :.
  Fly   410 EVKRQQRKLNFLITQTELYAHFMSKKLGQGSEEDQLRILSQLDEETNARLAAQDDYDAGEMKLLA 474

  Fly   352 QSNVPAVRVVKPTLNPPRAPSI-----DTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLES 411
            |.|..|  .::..|:..||..:     :..:.::..|:|.:|||
  Fly   475 QENAEA--AMQRDLDKTRAFDVFAKKKEKEEEEQAQESVEDIKP--------------------- 516

  Fly   412 LKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWMSWRERKLPRG--GILADDMGLGKTLT 474
              :....::|||.|::       .|.:|..:|   :..|:|......:|  |||||:||||||:.
  Fly   517 --EPRPEMKDLPQPKM-------FKGTLKGYQ---IKGMTWLANIYDQGISGILADEMGLGKTVQ 569

  Fly   475 MISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQW 539
            .|:  ..|...:....                       |          |..||:.|||.|..|
  Fly   570 SIA--FLCHIAEHYGV-----------------------W----------GPFLVISPASTLHNW 599

  Fly   540 ESEVESKVSRQKLTVCVHHGNNRETK-------GKYL--RD--YDIVVTTYQIVAREHKSLSAVF 593
            :.|:...|...|  |..:.|:..|.|       .|:|  ||  :.:|:|:||:|..::|..:.
  Fly   600 QQEMSRFVPDFK--VVPYWGSPAERKILRQFWDQKHLHTRDASFHVVITSYQLVVSDYKYFNR-- 660

  Fly   594 GVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLH 658
             :||:.::||||..:::..||....:.....:.|..|:||||||...:::|||.|:..:.||...
  Fly   661 -IKWQYMVLDEAQAIKSAASQRWKLLLGFSCRNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHD 724

  Fly   659 TWKKW--------------IDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIE 709
            .:.:|              ||.|..   :||::::|..||||.|..:::               |
  Fly   725 EFNEWFSKDIESHAENKTGIDEKQI---SRLHMILKPFMLRRIKKDVEN---------------E 771

  Fly   710 ISLDKEEMNVYQTVMTYSRTLF---------AQFLHQRAERETD-------------FNYRSDAN 752
            :| ||.|:.||..:....:.|:         ...||..:...|.             ..:|...|
  Fly   772 LS-DKIEIMVYCPLTIRQKLLYRALKQKIRIEDLLHLTSGSTTTSSSSSASNLMNLVMQFRKVCN 835

  Fly   753 KPTYNQIKDPNGAYYK----------MHEK----------------------------------- 772
            .|...:.:|....::.          :||:
  Fly   836 HPELFERRDARSPFFMRCAEYTIPRLIHEEGLIHRMLPSRKHLLYNRFNIFKSEYIQRSLFEDVN 900

  Fly   773 ------FARM----AGSKKEVKSHDILVLLLRLRQIC-CHP-----------------GLIDAML 809
                  |.|:    .|...||..:.::..||..|::. .:|                 .|::.||
  Fly   901 VNSCFGFTRLCDLSVGDMVEVTLNGLIDFLLHYRRVLEKYPLLAYRRFWWKKQPDSRYQLLEPML 965

  Fly   810 DGE-----------------------ESQ--TMGDHSS-----------------DSDTPEIDLL 832
            :.:                       ||.  ..||:.:                 ...|..|:.:
  Fly   966 ENKLALDYMPPNSVLKNFIFTAMTANESSVYAFGDYFTYNMQETIEHRVIRSKILKKKTSLIEEM 1030

  Fly   833 AQLNKLAITDTSTDGQQSVANAGDD----------------------------GPPLLPDEARIA 869
            ..::|..:...|.: .|:.:||..|                            .|.:|.|..:..
  Fly  1031 EDVSKQKLEIESVE-VQTKSNAKSDVKVTTLLLLPEFPHRPRKPRKYVCEPLSMPRILYDLGQKV 1094

  Fly   870 KASKNLLK-----------RSNPVFN------------LHRPSSKINMVIQILKTSI-------- 903
            :|....|.           |.|...|            |.:|....:.::...|.::
  Fly  1095 QAVHRYLYCDSRSAAWSQIRHNQCENSQGRELVSSGLALCKPHGGWSSIVVPDKETLITDAGKLF 1159

  Fly   904 --------LKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQ 960
                    ||::..:.::.||.|.::|:|.:::.......:.|:|:..:..|:|:|.:|..|.:
  Fly  1160 VLDNLLTRLKANGHRVLIYSQMTKMIDLLEEYMWHRKHRYMRLDGSSKISARRDMVADFQTRAD- 1223

  Fly   961 KRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQR 1025
            ..|.|||..|||:|:||..|:.::..|..|||.::.||.||.:|:||.|.|.:|:.:|..|:|:|
  Fly  1224 IFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEER 1288

  Fly  1026 IKGLQDKKLDLADGVLTGA---------KVSSKLTIDD 1054
            |.....:|.::...|::|.         |....|.:||
  Fly  1289 ILQRAREKSEIQRMVISGGNFKPDTLKPKEVVSLLLDD 1326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	SNF2_N	442..805	CDD:278600	103/484 (21%)
		DEXDc	459..634	CDD:238005	51/187 (27%)
		HELICc	885..1014	CDD:238034	41/144 (28%)
Ino80	NP_732413.1	DBINO	313..438	CDD:290603	27/144 (19%)
		SNF2_N	538..840	CDD:278600	91/363 (25%)
		DEXDc	555..700	CDD:238005	50/184 (27%)
		Helicase_C	1156..1269	CDD:278689	34/113 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467194
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930